Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Manuel IR"'
Autor:
Xavier Grau-Bové, Lucie Subirana, Lydvina Meister, Anaël Soubigou, Ana Neto, Anamaria Elek, Silvia Naranjo, Oscar Fornas, Jose Luis Gomez-Skarmeta, Juan J. Tena, Manuel Irimia, Stéphanie Bertrand, Arnau Sebé-Pedrós, Hector Escriva
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The emergence of new structures can often be linked to the evolution of novel cell types that follows the rewiring of developmental gene regulatory subnetworks. Vertebrates are characterized by a complex body plan compared to the other chord
Externí odkaz:
https://doaj.org/article/22d3055037d24ede9fd6eb9575c56c8f
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 4, Pp 296-310 (2024)
Abstract Alternative Splicing (AS) programs serve as instructive signals of cell type specificity, particularly within the brain, which comprises dozens of molecularly and functionally distinct cell types. Among them, retinal photoreceptors stand out
Externí odkaz:
https://doaj.org/article/c9361ca112c84184919d12cdbe14fc8e
Autor:
Ester Antón-Galindo, Maja R. Adel, Judit García-González, Adele Leggieri, Laura López-Blanch, Manuel Irimia, William H. J. Norton, Caroline H. Brennan, Noèlia Fernàndez-Castillo, Bru Cormand
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract RBFOX1 is a highly pleiotropic gene that contributes to several psychiatric and neurodevelopmental disorders. Both rare and common variants in RBFOX1 have been associated with several psychiatric conditions, but the mechanisms underlying the
Externí odkaz:
https://doaj.org/article/8aa026a5ba2f435b917e2d9d09838519
Autor:
Marina Brasó-Vives, Ferdinand Marlétaz, Amina Echchiki, Federica Mantica, Rafael D. Acemel, José L. Gómez-Skarmeta, Diego A. Hartasánchez, Lorlane Le Targa, Pierre Pontarotti, Juan J. Tena, Ignacio Maeso, Hector Escriva, Manuel Irimia, Marc Robinson-Rechavi
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-24 (2022)
Abstract Background Amphioxus are non-vertebrate chordates characterized by a slow morphological and molecular evolution. They share the basic chordate body-plan and genome organization with vertebrates but lack their 2R whole-genome duplications and
Externí odkaz:
https://doaj.org/article/3eafdefd55364d779da2b39cb4429adb
Autor:
Goutham Atla, Silvia Bonàs-Guarch, Mirabai Cuenca-Ardura, Anthony Beucher, Daniel J. M. Crouch, Javier Garcia-Hurtado, Ignasi Moran, the T2DSystems Consortium, Manuel Irimia, Rashmi B. Prasad, Anna L. Gloyn, Lorella Marselli, Mara Suleiman, Thierry Berney, Eelco J. P. de Koning, Julie Kerr-Conte, Francois Pattou, John A. Todd, Lorenzo Piemonti, Jorge Ferrer
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-28 (2022)
Abstract Background Non-coding genetic variants that influence gene transcription in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely also contribute to type 1 diabetes (T1D) risk. For many loci, however,
Externí odkaz:
https://doaj.org/article/cf1281e02aac42cea7c15b4711ce5611
Publikováno v:
PLoS Biology, Vol 21, Iss 2, p e3001986 (2023)
Circadian and circannual cycles trigger physiological changes whose reflection on human transcriptomes remains largely uncharted. We used the time and season of death of 932 individuals from GTEx to jointly investigate transcriptomic changes associat
Externí odkaz:
https://doaj.org/article/82d58d397cbc49aeb0eb05da427a7784
Autor:
Yamile Márquez, Federica Mantica, Luca Cozzuto, Demian Burguera, Antonio Hermoso-Pulido, Julia Ponomarenko, Scott W. Roy, Manuel Irimia
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-23 (2021)
Abstract Several bioinformatic tools have been developed for genome-wide identification of orthologous and paralogous genes. However, no corresponding tool allows the detection of exon homology relationships. Here, we present ExOrthist, a fully repro
Externí odkaz:
https://doaj.org/article/d469f42616ff41c5bc26f077a800e639
Autor:
Helena García-Castro, Nathan J. Kenny, Marta Iglesias, Patricia Álvarez-Campos, Vincent Mason, Anamaria Elek, Anna Schönauer, Victoria A. Sleight, Jakke Neiro, Aziz Aboobaker, Jon Permanyer, Manuel Irimia, Arnau Sebé-Pedrós, Jordi Solana
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-34 (2021)
Abstract Single-cell sequencing technologies are revolutionizing biology, but they are limited by the need to dissociate live samples. Here, we present ACME (ACetic-MEthanol), a dissociation approach for single-cell transcriptomics that simultaneousl
Externí odkaz:
https://doaj.org/article/545233f391c049b29663104de0e9910a
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-26 (2021)
Abstract Background Alternative splicing (AS) is a widespread regulatory mechanism in multicellular organisms. Numerous transcriptomic and single-gene studies in plants have investigated AS in response to specific conditions, especially environmental
Externí odkaz:
https://doaj.org/article/6230ac0713e740fd8a4e672599787ea9
Autor:
Thomas Spruce, Mireya Plass, André Gohr, Debashish Ray, María Martínez de Lagrán, Gregor Rot, Ana Nóvoa, Demian Burguera, Jon Permanyer, Marta Miret, Hong Zheng, Maurice S Swanson, Quaid Morris, Moises Mallo, Mara Dierssen, Timothy R Hughes, Barbara Pernaute, Manuel Irimia
Publikováno v:
PLoS Biology, Vol 20, Iss 4, p e3001615 (2022)
Understanding the regulatory interactions that control gene expression during the development of novel tissues is a key goal of evolutionary developmental biology. Here, we show that Mbnl3 has undergone a striking process of evolutionary specializati
Externí odkaz:
https://doaj.org/article/123842fa9e434a1097df0caff61e1e6d