Undefeated-Changing the phenamacril scaffold is not enough to beat resistant Fusarium.

Autor: Rasmus D Wollenberg, Søren S Donau, Manuel H Taft, Zoltan Balázs, Sven Giese, Claudia Thiel, Jens L Sørensen, Thorbjørn T Nielsen, Henriette Giese, Dietmar J Manstein, Reinhard Wimmer, Teis E Sondergaard

Publikováno v: PLoS ONE, Vol 15, Iss 6, p e0235568 (2020)

Filamentous fungi belonging to the genus Fusarium are notorious plant-pathogens that infect, damage and contaminate a wide variety of important crops. Phenamacril is the first member of a novel class of single-site acting cyanoacrylate fungicides whi

Externí odkaz: https://doaj.org/article/cdef8469221e44b98270913f548467c7

Small molecule-mediated refolding and activation of myosin motor function

Autor: Michael B Radke, Manuel H Taft, Britta Stapel, Denise Hilfiker-Kleiner, Matthias Preller, Dietmar J Manstein

Publikováno v: eLife, Vol 3 (2014)

The small molecule EMD 57033 has been shown to stimulate the actomyosin ATPase activity and contractility of myofilaments. Here, we show that EMD 57033 binds to an allosteric pocket in the myosin motor domain. EMD 57033-binding protects myosin agains

Externí odkaz: https://doaj.org/article/1c2b6f50130d4670973519e640507c6e

Distinct actin–tropomyosin cofilament populations drive the functional diversification of cytoskeletal myosin motor complexes

Autor: Theresia Reindl, Sven Giese, Johannes N. Greve, Patrick Y. Reinke, Igor Chizhov, Sharissa L. Latham, Daniel P. Mulvihill, Manuel H. Taft, Dietmar J. Manstein

Publikováno v: iScience, Vol 25, Iss 7, Pp 104484- (2022)

Summary: The effects of N-terminal acetylation of the high molecular weight tropomyosin isoforms Tpm1.6 and Tpm2.1 and the low molecular weight isoforms Tpm1.12, Tpm3.1, and Tpm4.2 on the actin affinity and the thermal stability of actin-tropomyosin

Externí odkaz: https://doaj.org/article/556ba07f2f664300a1a80037d71c6760

Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase

Autor: Marc R. Reboll, Stefanie Klede, Manuel H. Taft, Chen-Leng Cai, Loren J. Field, Kory J. Lavine, Andrew L. Koenig, Jenni Fleischauer, Johann Meyer, Axel Schambach, Hans W. Niessen, Maike Kosanke, Joop van den Heuvel, Andreas Pich, Johann Bauersachs, Xuekun Wu, Linqun Zheng, Yong Wang, Mortimer Korf-Klingebiel, Felix Polten, Kai C. Wollert

Publikováno v: Reboll, M R, Klede, S, Taft, M H, Cai, C-L, Field, L J, Lavine, K J, Koenig, A L, Fleischauer, J, Meyer, J, Schambach, A, Niessen, H W, Kosanke, M, van den Heuvel, J, Pich, A, Bauersachs, J, Wu, X, Zheng, L, Wang, Y, Korf-Klingebiel, M, Polten, F & Wollert, K C 2022, ' Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase ', Science, vol. 376, no. 6599, pp. 1343-1347 . https://doi.org/10.1126/science.abn3027
Science, 376(6599), 1343-1347. American Association for the Advancement of Science

Effective tissue repair after myocardial infarction entails a vigorous angiogenic response, guided by incompletely defined immune cell–endothelial cell interactions. We identify the monocyte- and macrophage-derived cytokine METRNL (meteorin-like) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ad5532374bacfed516c0ac7506067c
https://pubmed.ncbi.nlm.nih.gov/36544808

Assessment of the Contribution of a Thermodynamic and Mechanical Destabilization of Myosin–Binding Protein C Domain C2 to the Pathomechanism of Hypertrophic Cardiomyopathy–causing Double Mutation MYBPC3Δ25bp/D389V

Autor: Manuel H. Taft, Dietmar J. Manstein, Frederic V. Schwäbe, Emanuel K. Peter

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 11949, p 11949 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21

Mutations in the gene encoding cardiac myosin-binding protein-C (MyBPC), a thick filament assembly protein that stabilizes sarcomeric structure and regulates cardiac function, are a common cause for the development of hypertrophic cardiomyopathy. Abo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc175285ef91ebb0ccf796916385c6e