Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Manuel H Taft"'
Autor:
Despoina Kyriazi, Lea Voth, Almke Bader, Wiebke Ewert, Juliane Gerlach, Kerstin Elfrink, Peter Franz, Mariana I. Tsap, Bastian Schirmer, Julia Damiano-Guercio, Falk K. Hartmann, Masina Plenge, Azam Salari, Dennis Schöttelndreier, Katharina Strienke, Nadine Bresch, Claudio Salinas, Herwig O. Gutzeit, Nora Schaumann, Kais Hussein, Heike Bähre, Inga Brüsch, Peter Claus, Detlef Neumann, Manuel H. Taft, Halyna R. Shcherbata, Anaclet Ngezahayo, Martin Bähler, Mahdi Amiri, Hans-Joachim Knölker, Matthias Preller, Georgios Tsiavaliaris
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Aberrant Ras homologous (Rho) GTPase signalling is a major driver of cancer metastasis, and GTPase-activating proteins (GAPs), the negative regulators of RhoGTPases, are considered promising targets for suppressing metastasis, yet drug disco
Externí odkaz:
https://doaj.org/article/2b9783ca646c4ead8685a39b451c0553
Autor:
Manuel H. Taft, Maria Jolanta Redowicz
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/e2611f436a6a4684b4b7ff9806f83649
Autor:
Johannes N Greve, Anja Marquardt, Robin Heiringhoff, Theresia Reindl, Claudia Thiel, Nataliya Di Donato, Manuel H Taft, Dietmar J Manstein
Publikováno v:
eLife, Vol 12 (2024)
Various heterozygous cytoskeletal γ-actin mutations have been shown to cause Baraitser–Winter cerebrofrontofacial syndrome, non-syndromic hearing loss, or isolated eye coloboma. Here, we report the biochemical characterization of human cytoskeleta
Externí odkaz:
https://doaj.org/article/321319569cd148a5aa5e8707afca94db
Autor:
Theresia Reindl, Sven Giese, Johannes N. Greve, Patrick Y. Reinke, Igor Chizhov, Sharissa L. Latham, Daniel P. Mulvihill, Manuel H. Taft, Dietmar J. Manstein
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104484- (2022)
Summary: The effects of N-terminal acetylation of the high molecular weight tropomyosin isoforms Tpm1.6 and Tpm2.1 and the low molecular weight isoforms Tpm1.12, Tpm3.1, and Tpm4.2 on the actin affinity and the thermal stability of actin-tropomyosin
Externí odkaz:
https://doaj.org/article/556ba07f2f664300a1a80037d71c6760
Autor:
Johannes N. Greve, Frederic V. Schwäbe, Thomas Pokrant, Jan Faix, Nataliya Di Donato, Manuel H. Taft, Dietmar J. Manstein
Publikováno v:
European Journal of Cell Biology, Vol 101, Iss 2, Pp 151216- (2022)
Heterozygous dominant mutations in the ubiquitously produced cytoskeletal β–actin isoform lead to a broad range of human disease phenotypes, which are currently classified as three distinct clinical entities termed Baraitser-Winter–Cerebrofronto
Externí odkaz:
https://doaj.org/article/f4cd10b5d3b14de5b63c994899b160c7
Autor:
Rasmus D Wollenberg, Søren S Donau, Manuel H Taft, Zoltan Balázs, Sven Giese, Claudia Thiel, Jens L Sørensen, Thorbjørn T Nielsen, Henriette Giese, Dietmar J Manstein, Reinhard Wimmer, Teis E Sondergaard
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0235568 (2020)
Filamentous fungi belonging to the genus Fusarium are notorious plant-pathogens that infect, damage and contaminate a wide variety of important crops. Phenamacril is the first member of a novel class of single-site acting cyanoacrylate fungicides whi
Externí odkaz:
https://doaj.org/article/cdef8469221e44b98270913f548467c7
Autor:
Sharissa L. Latham, Nadja Ehmke, Patrick Y. A. Reinke, Manuel H. Taft, Dorothee Eicke, Theresia Reindl, Werner Stenzel, Michael J. Lyons, Michael J. Friez, Jennifer A. Lee, Ramona Hecker, Michael C. Frühwald, Kerstin Becker, Teresa M. Neuhann, Denise Horn, Evelin Schrock, Indra Niehaus, Katharina Sarnow, Konrad Grützmann, Luzie Gawehn, Barbara Klink, Andreas Rump, Christine Chaponnier, Constanca Figueiredo, Ralf Knöfler, Dietmar J. Manstein, Nataliya Di Donato
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Genetic variants in ACTB and ACTG1 have been associated with Baraitser-Winter Cerebrofrontofacial syndrome. Here, the authors report of a syndromic thrombocytopenia caused by variants in ACTB exons 5 or 6 that compromise the organization and coupling
Externí odkaz:
https://doaj.org/article/569cb18d81a94fddbe69e1080068e13d
Autor:
Aleksandra Shcherbakova, Matthias Preller, Manuel H Taft, Jordi Pujols, Salvador Ventura, Birgit Tiemann, Falk FR Buettner, Hans Bakker
Publikováno v:
eLife, Vol 8 (2019)
Previous studies demonstrated importance of C-mannosylation for efficient protein secretion. To study its impact on protein folding and stability, we analyzed both C-mannosylated and non-C-mannosylated thrombospondin type 1 repeats (TSRs) of netrin r
Externí odkaz:
https://doaj.org/article/573919a03a124259935a6d4050ce1cfe
Autor:
Vincent A. Behrens, Stefan Münnich, Georg Adler-Gunzelmann, Claudia Thiel, Arnon Henn, Sharissa L. Latham, Manuel H. Taft
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Myosin motor proteins convert chemical energy into force and movement through their interactions with nucleotide and filamentous actin (F-actin). The evolutionarily conserved lysine-265 (K265) of the myosin-2 motor from Dictyostelium discoid
Externí odkaz:
https://doaj.org/article/eaaa298420cf47cbb9f594859b1b21ab
Autor:
Marc R. Reboll, Stefanie Klede, Manuel H. Taft, Chen-Leng Cai, Loren J. Field, Kory J. Lavine, Andrew L. Koenig, Jenni Fleischauer, Johann Meyer, Axel Schambach, Hans W. Niessen, Maike Kosanke, Joop van den Heuvel, Andreas Pich, Johann Bauersachs, Xuekun Wu, Linqun Zheng, Yong Wang, Mortimer Korf-Klingebiel, Felix Polten, Kai C. Wollert
Publikováno v:
Reboll, M R, Klede, S, Taft, M H, Cai, C-L, Field, L J, Lavine, K J, Koenig, A L, Fleischauer, J, Meyer, J, Schambach, A, Niessen, H W, Kosanke, M, van den Heuvel, J, Pich, A, Bauersachs, J, Wu, X, Zheng, L, Wang, Y, Korf-Klingebiel, M, Polten, F & Wollert, K C 2022, ' Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase ', Science, vol. 376, no. 6599, pp. 1343-1347 . https://doi.org/10.1126/science.abn3027
Science, 376(6599), 1343-1347. American Association for the Advancement of Science
Science, 376(6599), 1343-1347. American Association for the Advancement of Science
Effective tissue repair after myocardial infarction entails a vigorous angiogenic response, guided by incompletely defined immune cell–endothelial cell interactions. We identify the monocyte- and macrophage-derived cytokine METRNL (meteorin-like) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ad5532374bacfed516c0ac7506067c
https://pubmed.ncbi.nlm.nih.gov/36544808
https://pubmed.ncbi.nlm.nih.gov/36544808