Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Manuel Glaser"'
Autor:
Hanno Schmidt, Katharina Mauer, Manuel Glaser, Bahram Sayyaf Dezfuli, Sören Lukas Hellmann, Ana Lúcia Silva Gomes, Falk Butter, Rebecca C. Wade, Thomas Hankeln, Holger Herlyn
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Background With the expansion of animal production, parasitic helminths are gaining increasing economic importance. However, application of several established deworming agents can harm treated hosts and environment due to their low specific
Externí odkaz:
https://doaj.org/article/a3b5918acef8482ea504a636b130d8eb
Autor:
Jan Schoenfelder, Sebastian Kohl, Manuel Glaser, Sebastian McRae, Jens O. Brunner, Thomas Koperna
Publikováno v:
BMC Health Services Research, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background Since operating rooms are a major bottleneck resource and an important revenue driver in hospitals, it is important to use these resources efficiently. Studies estimate that between 60 and 70% of hospital admissions are due to sur
Externí odkaz:
https://doaj.org/article/3f9c17d85a15429b96f85e1384e58529
Autor:
Stefan Audehm, Manuel Glaser, Matteo Pecoraro, Eva Bräunlein, Sabine Mall, Richard Klar, Manuel Effenberger, Julian Albers, Henrique de Oliveira Bianchi, Janet Peper, Nahid Yusufi, Dirk H. Busch, Stefan Stevanović, Matthias Mann, Iris Antes, Angela M. Krackhardt
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Adoptive transfer of T cells transgenic for tumor-reactive T-cell receptors (TCR) is an attractive immunotherapeutic approach. However, clinical translation is so far limited due to challenges in the identification of suitable target antigens as well
Externí odkaz:
https://doaj.org/article/22a2a126e49249719ac2dc109a786b0d
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205057 (2018)
The allosteric activation of the intrinsically disordered enzyme Staphylococcus aureus sortase A is initiated via binding of a Ca2+ ion. Although Ca2+ binding was shown to initiate structural changes inducing disorder-to-order transitions, the detail
Externí odkaz:
https://doaj.org/article/fb114bf5e99a4673bfe17f4ef4d46bf8
Autor:
Dorothea Kehr, Julia Ritterhoff, Manuel Glaser, Lukas Jarosch, Rafael E. Salazar, Kristin Spaich, Karl Varadi, Jennifer Birkenstock, Michael Egger, Erhe Gao, Walter J. Koch, Hugo A. Katus, Norbert Frey, Andreas Jungmann, Cornelius Busch, Paul J. Mather, Arjang Ruhparwar, Mirko Völkers, Rebecca C. Wade, Patrick Most
BackgroundThe EF-hand Ca2+sensor protein S100A1 has been identified as a molecular regulator and enhancer of cardiac performance. S100A1’s ability to recognize and modulate the activity of targets such as SERCA2a and RyR2 in cardiomyocytes has most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecb3004b44244dbaf42749e450e246fb
https://doi.org/10.1101/2023.03.04.531024
https://doi.org/10.1101/2023.03.04.531024
Autor:
Zegeye H. Jebessa, Manuel Glaser, Jemmy Zhao, Andrea Schneider, Ramkumar Seenivasan, Martin Busch, Julia Ritterhoff, Rebecca C. Wade, Patrick Most
S100A1 is a small EF-type Ca2+sensor protein that belongs to the multigenic S100 protein family. It is abundantly expressed in cardiomyocytes (CMs) and has been described as a key regulator of CM performance due to its unique ability to interact with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39a385ff862ffbc4aae7276472db1f07
https://doi.org/10.1101/2023.01.18.524665
https://doi.org/10.1101/2023.01.18.524665
Autor:
Zegeye Hailu Jebessa, Manuel Glaser, Andrea Schneider, Jemmy Zhao, Ramkumar Seenivasan, Martin Busch, Rebecca Wade, Patrick Most
Publikováno v:
Circulation Research. 131
Background & Objectives: S100A1 protein is a 10 kDa Ca 2+ sensor & abundantly expressed in cardiomyocytes (CMs) of vertebrates. Marked reduction in S100A1 level is hallmark of diseased heart, vice versa, addition of S100A1 by gene transfer rescues di
Autor:
Michael Egger, Manuel Glaser, Andreas Jungmann, Azmal A Syed, Jeroen Krijgsveld, Martin Busch, Rebecca Wade, Patrick Most
Publikováno v:
Circulation Research. 131
Background and Hypothesis: Loss of S100A1 expression in heart failure contributes to adverse cardiomyocyte (CM) remodeling via an unknown molecular mechanism. Conversely, the antihypertrophic effect of viral-based restoration of S100A1 expression in
Autor:
Zegeye Hailu Jebessa, Manuel Glaser, Andrea Schnieder, Jemmy Zhao, Ramkumar Seenivasan, Martin Busch, Rebecca Wade, Patrick Most
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:162
Publikováno v:
The journal of physical chemistry. B. 125(18)
The S100A1ct peptide, consisting of the C-terminal 20 residues of the S100A1 protein fused to an N-terminal 6-residue hydrophilic tag, has been found to exert a positive inotropic effect, resulting in improved contractile performance of failing cardi