Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Manuel Garcia-Albornoz"'
Autor:
Fernando Anjos-Afonso, Florian Buettner, Syed A. Mian, Hefin Rhys, Jimena Perez-Lloret, Manuel Garcia-Albornoz, Namrata Rastogi, Linda Ariza-McNaughton, Dominique Bonnet
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The trajectories of hematopoietic stem cells (HSCs) during lineage commitment are complex. Here, the authors use single cell RNA-sequencing and xenotransplantation to uncover CD34 + EPCR + (CD38/CD45RA)- HSCs, which high repopulating and self-renewal
Externí odkaz:
https://doaj.org/article/9098d9db691f404ea49a1ba5251c1c75
Autor:
Ibrahim E. Elsemman, Angelica Rodriguez Prado, Pranas Grigaitis, Manuel Garcia Albornoz, Victoria Harman, Stephen W. Holman, Johan van Heerden, Frank J. Bruggeman, Mark M. M. Bisschops, Nikolaus Sonnenschein, Simon Hubbard, Rob Beynon, Pascale Daran-Lapujade, Jens Nielsen, Bas Teusink
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Metabolically active organelles compete for cytosolic space and resources during metabolism rewiring. Here, the authors develop a computational model of yeast metabolism and resource allocation to predict condition- and compartment-specific proteome
Externí odkaz:
https://doaj.org/article/c9208717b9f645ce8b0fdca3215e4a74
Autor:
Sara Ali, Syed Mian, William Grey, Manuel Garcia-Albornoz, Fatihah Mohamad Nor, Aneesh Sharma, Samantha Atkinson, Linda Ariza McNaughton, John G. Gribben, Dominique Bonnet
Publikováno v:
Blood. 140:5781-5781
Autor:
Hector Huerga Encabo, Iker Aramburu, Anna Song, Manuel Garcia-Albornoz, Henry Wood, Venizelos Papayannopoulos, Dominique Bonnet
Publikováno v:
Experimental Hematology. 111:S94-S95
Autor:
Manuel Garcia-Albornoz, Simon J. Hubbard, Chuan Fu Yap, Jean-Marc Schwartz, Andrew F. Jarnuczak
Publikováno v:
Yap, C F, Garcia Albornoz, M, Jarnuczak, A, Hubbard, S & Schwartz, J-M 2021, ' Model Parameterization with Quantitative Proteomics: Case Study with Trehalose Metabolism in Saccharomyces cerevisiae ', Processes, vol. 9, 139 . https://doi.org/10.3390/pr9010139
Processes
Volume 9
Issue 1
Processes, Vol 9, Iss 139, p 139 (2021)
Processes
Volume 9
Issue 1
Processes, Vol 9, Iss 139, p 139 (2021)
When Saccharomyces cerevisiae undergoes heat stress it stimulates several changes that are necessary for its survival, notably in carbon metabolism. Notable changes include increase in trehalose production and glycolytic flux. The increase in glycoly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c4fe47f9fd8a1c88430f001b6a1bd9
https://doi.org/10.3390/pr9010139
https://doi.org/10.3390/pr9010139
Autor:
Dominique Bonnet, Manuel Garcia-Albornoz, Hector Huerga Encabo, Marion Piganeau, Neil Q. McDonald, Rakhee Chauhan, William Grey
Publikováno v:
Blood. 136(22)
Expansion of human hematopoietic stem cells (HSCs) is a rapidly advancing field showing great promise for clinical applications. Recent evidence has implicated the nervous system and glial family ligands (GFLs) as potential drivers of hematopoietic s
Autor:
Stephen W. Holman, Manuel Garcia-Albornoz, Bas Teusink, T. Antonisse, Pascale Daran-Lapujade, Robert J. Beynon, Simon J. Hubbard
Publikováno v:
Molecular Omics
Molecular Omics, 16(1)
Garcia-Albornoz, M, Holman, S W, Antonisse, T, Daran-Lapujade, P, Teusink, B, Beynon, R J & Hubbard, S J 2020, ' A proteome-integrated, carbon source dependent genetic regulatory network in Saccharomyces cerevisiae ', Molecular Omics, vol. 16, no. 1, pp. 59-72 . https://doi.org/10.1039/c9mo00136k
Garcia Albornoz, M, Holman, S W, Antonisse, T, Daran-Lapujade, P, Teusink, B, Beynon, R J & Hubbard, S 2019, ' A proteome-integrated, carbon source dependent genetic regulatory network in Saccharomyces cerevisiae ', Molecular Omics . https://doi.org/10.1039/C9MO00136K
Molecular Omics, 16(1), 59-72. Royal Society of Chemistry
Molecular Omics, 16(1)
Garcia-Albornoz, M, Holman, S W, Antonisse, T, Daran-Lapujade, P, Teusink, B, Beynon, R J & Hubbard, S J 2020, ' A proteome-integrated, carbon source dependent genetic regulatory network in Saccharomyces cerevisiae ', Molecular Omics, vol. 16, no. 1, pp. 59-72 . https://doi.org/10.1039/c9mo00136k
Garcia Albornoz, M, Holman, S W, Antonisse, T, Daran-Lapujade, P, Teusink, B, Beynon, R J & Hubbard, S 2019, ' A proteome-integrated, carbon source dependent genetic regulatory network in Saccharomyces cerevisiae ', Molecular Omics . https://doi.org/10.1039/C9MO00136K
Molecular Omics, 16(1), 59-72. Royal Society of Chemistry
Integrated regulatory networks can be powerful tools to examine and test properties of cellular systems, such as modelling environmental effects on the molecular bioeconomy, where protein levels are altered in response to changes in growth conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7ba7af74b6dcb78f7733547fbb723e
http://livrepository.liverpool.ac.uk/3070518/1/19_GarciaAlborniz_Momics.pdf
http://livrepository.liverpool.ac.uk/3070518/1/19_GarciaAlborniz_Momics.pdf
Autor:
Probir Chakravarty, Luigi Ombrato, Ilaria Malanchi, John G. Gribben, Ander Abarrategi, Manuel Garcia-Albornoz, Linda Ariza-McNaughton, Dominique Bonnet, Giovanni Diana, Diana Passaro, Antoniana Batsivari, Clara Borràs-Eroles, Alexander Waclawiczek
Publikováno v:
Cell Reports
Summary The bone-marrow (BM) niche is the spatial environment composed by a network of multiple stromal components regulating adult hematopoiesis. We use multi-omics and computational tools to analyze multiple BM environmental compartments and deciph
Autor:
Jude Fitzgibbon, Dominique Bonnet, David Taussig, Alexander Waclawiczek, Kevin Rouault-Pierre, Nourdine Bah, John G. Gribben, Manuel Garcia Albornoz, Ander Abarrategi, Ashley Hamilton, Farideh Miraki-Moud
Publikováno v:
The Journal of Clinical Investigation
Acute myeloid leukemia (AML) disrupts the generation of normal blood cells, predisposing patients to hemorrhage, anemia, and infections. Differentiation and proliferation of residual normal hematopoietic stem and progenitor cells (HSPCs) are impeded
Autor:
Malgorzata Adamczyk, Emil Furmanek, Stephen W. Holman, Roza Szatkowska, Simon J. Hubbard, Manuel Garcia-Albornoz, Robert J. Beynon, Katarzyna Roszkowska
Publikováno v:
BIOCHEMICAL JOURNAL
Szatkowska, R, Garcia-Albornoz, M, Roszkowska, K, Holman, S W, Furmanek, E, Hubbard, S J, Beynon, R J & Adamczyk, M 2019, ' Glycolytic flux in Saccharomyces cerevisiae is dependent on RNA polymerase III and its negative regulator Maf1 ', Biochemical Journal, vol. 476, no. 7, pp. 1053-1082 . https://doi.org/10.1042/BCJ20180701
Szatkowska, R, Garcia-Albornoz, M, Roszkowska, K, Holman, S W, Furmanek, E, Hubbard, S J, Beynon, R J & Adamczyk, M 2019, ' Glycolytic flux in Saccharomyces cerevisiae is dependent on RNA polymerase III and its negative regulator Maf1 ', Biochemical Journal, vol. 476, no. 7, pp. 1053-1082 . https://doi.org/10.1042/BCJ20180701
Protein biosynthesis is energetically costly, is tightly regulated and is coupled to stress conditions including glucose deprivation. RNA polymerase III (RNAP III)-driven transcription of tDNA genes for production of tRNAs is a key element in efficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67dd53d14da3b97baac580ad54bebc3a
http://livrepository.liverpool.ac.uk/3036068/1/19_Statzkowska_BJ.pdf
http://livrepository.liverpool.ac.uk/3036068/1/19_Statzkowska_BJ.pdf