Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Manuel F Navedo"'
Autor:
Kwun Nok Mimi Man, Peter Bartels, Peter B Henderson, Karam Kim, Mei Shi, Mingxu Zhang, Sheng-Yang Ho, Madeline Nieves-Cintron, Manuel F Navedo, Mary C Horne, Johannes W Hell
Publikováno v:
eLife, Vol 12 (2023)
The cellular mechanisms mediating norepinephrine (NE) functions in brain to result in behaviors are unknown. We identified the L-type Ca2+ channel (LTCC) CaV1.2 as a principal target for Gq-coupled α1-adrenergic receptors (ARs). α1AR signaling incr
Externí odkaz:
https://doaj.org/article/3817fb9d55da497485e8cde29a419fb9
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/25ca6893fdcb43e69bb6e6d23ff57273
Autor:
Frank K Lee, Jane C Lee, Bo Shui, Shaun Reining, Megan Jibilian, David M Small, Jason S Jones, Nathaniel H Allan-Rahill, Michael RE Lamont, Megan A Rizzo, Sendoa Tajada, Manuel F Navedo, Luis Fernando Santana, Nozomi Nishimura, Michael I Kotlikoff
Publikováno v:
eLife, Vol 10 (2021)
Optogenetic effectors and sensors provide a novel real-time window into complex physiological processes, enabling determination of molecular signaling processes within functioning cellular networks. However, the combination of these optical tools in
Externí odkaz:
https://doaj.org/article/1b8cb82950fd45838080d740449051eb
Autor:
Ao Shen, Dana Chen, Manpreet Kaur, Peter Bartels, Bing Xu, Qian Shi, Joseph M Martinez, Kwun-nok Mimi Man, Madeline Nieves-Cintron, Johannes W Hell, Manuel F Navedo, Xi-Yong Yu, Yang K Xiang
Publikováno v:
eLife, Vol 8 (2019)
G protein-coupled receptors (GPCRs) transduce pleiotropic intracellular signals in mammalian cells. Here, we report neuronal excitability of β-blockers carvedilol and alprenolol at clinically relevant nanomolar concentrations. Carvedilol and alpreno
Externí odkaz:
https://doaj.org/article/266d8af6235543e79ba88e11968e5dbc
Autor:
Maria Paz Prada, Arsalan U Syed, Olivia R Buonarati, Gopireddy R Reddy, Matthew A Nystoriak, Debapriya Ghosh, Sergi Simó, Daisuke Sato, Kent C Sasse, Sean M Ward, Luis F Santana, Yang K Xiang, Johannes W Hell, Madeline Nieves-Cintrón, Manuel F Navedo
Publikováno v:
eLife, Vol 8 (2019)
Elevated glucose increases vascular reactivity by promoting L-type CaV1.2 channel (LTCC) activity by protein kinase A (PKA). Yet, how glucose activates PKA is unknown. We hypothesized that a Gs-coupled P2Y receptor is an upstream activator of PKA med
Externí odkaz:
https://doaj.org/article/834ddbe5b2af4b2d9cbfe39b3182cbe7
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 1, p e1005906 (2018)
In ventricular myocytes, membrane depolarization during the action potential (AP) causes synchronous activation of multiple L-type CaV1.2 channels (LTCCs), which trigger the release of calcium (Ca2+) from the sarcoplasmic reticulum (SR). This results
Externí odkaz:
https://doaj.org/article/345a2f24d5734d079a047225020f28f6
Autor:
Victor A. Flores‐Tamez, Miguel Martín‐Aragón Baudel, Junyoung Hong, Jade L. Taylor, Lu Ren, Thanhmai Le, Arsalan U. Syed, Yumna Moustafa, Navid Singhrao, Wendy R. Lemus‐Martinez, Gopireddy R. Reddy, Victoria Ramer, Kwun Nok Mimi Man, Peter Bartels, Ye Chen‐Izu, Chao‐Yin Chen, Sergi Simo, Eamonn J. Dickson, Stefano Morotti, Eleonora Grandi, L. Fernando Santana, Johannes W. Hell, Mary C. Horne, Madeline Nieves‐Cintrón, Manuel F. Navedo
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 20 (2024)
Background Increased vascular CaV1.2 channel function causes enhanced arterial tone during hypertension. This is mediated by elevations in angiotensin II/protein kinase C signaling. Yet, the mechanisms underlying these changes are unclear. We hypothe
Externí odkaz:
https://doaj.org/article/3442030d4e57470fb2eaf2e11402d37c
Autor:
Rose E Dixon, Claudia M Moreno, Can Yuan, Ximena Opitz-Araya, Marc D Binder, Manuel F Navedo, Luis F Santana
Publikováno v:
eLife, Vol 4 (2015)
In the heart, reliable activation of Ca2+ release from the sarcoplasmic reticulum during the plateau of the ventricular action potential requires synchronous opening of multiple CaV1.2 channels. Yet the mechanisms that coordinate this simultaneous op
Externí odkaz:
https://doaj.org/article/284f6017002540988358c675a498745e
Publikováno v:
Physiol Rev
Ion channels play a central role in the regulation of nearly every cellular process. Dating back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion channels have always been thought of as independent agents. A m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcdaec94a95f3c27d73a951ccc9fe162
https://pubmed.ncbi.nlm.nih.gov/34927454
https://pubmed.ncbi.nlm.nih.gov/34927454
Autor:
Junyoung Hong, Miguel Martin-Aragon Baudel, Gopyreddy R Reddy, Yumna A Moustafa, Jose W Ayende, Yaseen Mohabbat, Brant E Isakson, Madeline Nieves-Cintron, Manuel F Navedo
Publikováno v:
Physiology. 38
Vascular complications are major causes of morbidity and mortality in diabetic patients. Recently, our group identified a novel purinergic signaling pathway involving the AKAP5/P2Y11/AC5/PKA/CaV1.2 protein network in arterial myocytes that is activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5346c9c048c352604d9808f73aa12abf
https://doi.org/10.1152/physiol.2023.38.s1.5731650
https://doi.org/10.1152/physiol.2023.38.s1.5731650