Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Manuel Ehling"'
Autor:
Noemi Gioelli, Lisa J. Neilson, Na Wei, Giulia Villari, Wenqian Chen, Bernhard Kuhle, Manuel Ehling, Federica Maione, Sander Willox, Serena Brundu, Daniele Avanzato, Grigorios Koulouras, Massimiliano Mazzone, Enrico Giraudo, Xiang-Lei Yang, Donatella Valdembri, Sara Zanivan, Guido Serini
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Functional vascular tree formation is a key step in many contexts, such as cancer, and Neuropilin1 (NRP1) has been associated with adhesion receptor endocytic turnover. Here, authors show NRP1 and its mini-WARS ligand play a role in reducing endothel
Externí odkaz:
https://doaj.org/article/2f35d1709b354aba9e4278bad5764f45
Autor:
Alessio Menga, Marina Serra, Simona Todisco, Carla Riera‐Domingo, Ummi Ammarah, Manuel Ehling, Erika M Palmieri, Maria Antonietta Di Noia, Rosanna Gissi, Maria Favia, Ciro L Pierri, Paolo E Porporato, Alessandra Castegna, Massimiliano Mazzone
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 10, Pp n/a-n/a (2020)
Abstract Glutamine synthetase (GS) generates glutamine from glutamate and controls the release of inflammatory mediators. In macrophages, GS activity, driven by IL10, associates to the acquisition of M2‐like functions. Conditional deletion of GS in
Externí odkaz:
https://doaj.org/article/2172c31045fb4eb88d755d43558791aa
Autor:
Jiahui Cao, Manuel Ehling, Sigrid März, Jochen Seebach, Katsiaryna Tarbashevich, Tomas Sixta, Mara E. Pitulescu, Ann-Cathrin Werner, Boris Flach, Eloi Montanez, Erez Raz, Ralf H. Adams, Hans Schnittler
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-20 (2017)
The formation of new blood vessels requires both polarized cell migration and coordinated control of endothelial cell contacts. Here, Cao and colleagues describe at the sub-cellular level the cytoskeletal and cell junction dynamics regulating these p
Externí odkaz:
https://doaj.org/article/e445ed86f1b4415cb0e943b34a211150
Autor:
Ward Celus, Giusy Di Conza, Ana Isabel Oliveira, Manuel Ehling, Bruno M. Costa, Mathias Wenes, Massimiliano Mazzone
Publikováno v:
Cell Reports, Vol 21, Iss 10, Pp 2842-2854 (2017)
Summary: Although it is well established that tumor-associated macrophages take part in each step of cancer progression, less is known about the distinct role of the so-called metastasis-associated macrophages (MAMs) at the metastatic site. Previous
Externí odkaz:
https://doaj.org/article/e0035f2fe1384fc0b9253d878eb2d9da
Autor:
Giusy Di Conza, Sarah Trusso Cafarello, Stefan Loroch, Daniela Mennerich, Sofie Deschoemaeker, Mario Di Matteo, Manuel Ehling, Kris Gevaert, Hans Prenen, Rene Peiman Zahedi, Albert Sickmann, Thomas Kietzmann, Fabiola Moretti, Massimiliano Mazzone
Publikováno v:
Cell Reports, Vol 18, Iss 7, Pp 1699-1712 (2017)
Oxygen-dependent HIF1α hydroxylation and degradation are strictly controlled by PHD2. In hypoxia, HIF1α partly escapes degradation because of low oxygen availability. Here, we show that PHD2 is phosphorylated on serine 125 (S125) by the mechanistic
Externí odkaz:
https://doaj.org/article/dbfcf322e77844fe8764d55486a3635a
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41116 (2012)
Notch signaling controls fundamental aspects of angiogenic blood vessel growth including the selection of sprouting tip cells, endothelial proliferation and arterial differentiation. The E3 ubiquitin ligase Fbxw7 is part of the SCF protein complex re
Externí odkaz:
https://doaj.org/article/79b986596e4349819b96c8c2f4b21276
Autor:
Damya Laoui, Jo A. Van Ginderachter, Mohamed Lamkanfi, Andy Wullaert, Alain Beschin, Massimiliano Mazzone, Diether Lambrechts, Geert van Loo, Geert Raes, Louis Boon, Amelie Fossoul, Ayla Debraekeleer, Jan Brughmans, Maryse Schmoetten, Yvon Elkrim, Sana M. Arnouk, Pauline M.R. Bardet, Jiri Keirsse, Evangelia Bolli, Samantha Pretto, Manuel Ehling, Junbin Qian, Aleksandar Murgaski, Helena Van Damme, Els Lebegge, Pedro H.V. Saavedra, Lieselotte Vande Walle, Máté Kiss
Supplementary Figures 1-11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac555aa6d9d63833368748b3be0a555
https://doi.org/10.1158/2326-6066.22543494
https://doi.org/10.1158/2326-6066.22543494
Autor:
Damya Laoui, Jo A. Van Ginderachter, Mohamed Lamkanfi, Andy Wullaert, Alain Beschin, Massimiliano Mazzone, Diether Lambrechts, Geert van Loo, Geert Raes, Louis Boon, Amelie Fossoul, Ayla Debraekeleer, Jan Brughmans, Maryse Schmoetten, Yvon Elkrim, Sana M. Arnouk, Pauline M.R. Bardet, Jiri Keirsse, Evangelia Bolli, Samantha Pretto, Manuel Ehling, Junbin Qian, Aleksandar Murgaski, Helena Van Damme, Els Lebegge, Pedro H.V. Saavedra, Lieselotte Vande Walle, Máté Kiss
IL1β is a central mediator of inflammation. Secretion of IL1β typically requires proteolytic maturation by the inflammasome and formation of membrane pores by gasdermin D (GSDMD). Emerging evidence suggests an important role for IL1β in promoting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17834bb72b19f02c483a544d32dc5d61
https://doi.org/10.1158/2326-6066.c.6550290
https://doi.org/10.1158/2326-6066.c.6550290
Autor:
Mate Kiss, Geert Raes, Maryse Schmoetten, Helena Van Damme, Andy Wullaert, Jiri Keirsse, Mohamed Lamkanfi, Yvon Elkrim, Pauline M. R. Bardet, Junbin Qian, Aleksandar Murgaski, Louis Boon, Diether Lambrechts, Samantha Pretto, Alain Beschin, Geert van Loo, Massimiliano Mazzone, Manuel Ehling, Jo A. Van Ginderachter, Damya Laoui, Sana M. Arnouk, Evangelia Bolli, Ayla Debraekeleer, Amelie Fossoul, Els Lebegge, Jan Brughmans, Lieselotte Vande Walle, Pedro Henrique Viana Saavedra
IL1β is a central mediator of inflammation. Secretion of IL1β typically requires proteolytic maturation by the inflammasome and formation of membrane pores by gasdermin D (GSDMD). Emerging evidence suggests an important role for IL1β in promoting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ecbd8e2b94bd021c47f81139d016a57
https://doi.org/10.1158/2326-6066.cir-20-0431
https://doi.org/10.1158/2326-6066.cir-20-0431
Autor:
Van Ginderachter Ja, Samantha Pretto, Amelie Fossoul, Mohamed Lamkanfi, Manuel Ehling, Mate Kiss, Damya Laoui, Martins Ms, Andy Wullaert, Yvon Elkrim, Aleksandar Murgaski, Jiri Keirsse, Els Lebegge, D Lambrechts, Massimiliano Mazzone, Vande Walle L, Junbin Qian, Van Damme H, Evangelia Bolli
Interleukin-1β (IL-1β) is a central mediator of inflammation whose secretion typically requires proteolytic maturation by the inflammasome and formation of membrane pores by gasdermin D (GSDMD). Emerging evidence suggests an important role for IL-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::217b22e144aa2f462cc5b99784816db1
https://doi.org/10.1101/2020.08.04.235796
https://doi.org/10.1101/2020.08.04.235796