Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Manuel Debono"'
Autor:
Mark James Zweifel, Michael John Rodriguez, J. Tang, Doug Zeckner, Burkhardt Frederick Joseph, William W. Turner, Robert S. Gordee, Lisa Marie Hammond Lagrandeur, Manuel Debono, Nissen Jeffrey S, T. R. J. Parr, K. K. Nichols
Publikováno v:
Journal of Medicinal Chemistry. 38:3271-3281
Echinocandin B (ECB) is a lipopeptide composed of a complex cyclic peptide acylated at the N-terminus by linoleic acid. Enzymatic deacylation of ECB provided the peptide "nucleus" as a biologically inactive substrate from which novel ECB analogs were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5e81929325143b8b76b4311289394b
https://doi.org/10.1021/jm00017a012
https://doi.org/10.1021/jm00017a012
Autor:
Manuel Debono
Publikováno v:
Expert Opinion on Therapeutic Patents. 5:771-786
The search for new and effective antifungal agents has been intensified by the increase in the incidence of opportunistic infections due to immunological diseases and aggressive immunosuppressive chemotherapy. Natural products have provided several n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41a6c5ae708398f5b29de89ff83d8416
https://doi.org/10.1517/13543776.5.8.771
https://doi.org/10.1517/13543776.5.8.771
Autor:
Robert S. Gordee, Manuel Debono
Publikováno v:
Annual Review of Microbiology. 48:471-497
The discovery of antifungal agents that possess selective toxicity against the eukaryotic fungal cell remains an important scientific challenge. The growing medical need for safe and effective antifungal agents stems from the rapidly increasing popul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2506c8d53010162e3bffc60d58b1915
https://doi.org/10.1146/annurev.mi.48.100194.002351
https://doi.org/10.1146/annurev.mi.48.100194.002351
Autor:
Manuel Debono
Publikováno v:
Expert Opinion on Investigational Drugs. 3:821-829
The greater incidence of AIDS and use of myelosuppressive therapy has increased the demand for effective antifungal therapy. Currently availiable therapy has limitations associated with toxicity and resistance potential. The ideal agent is selectivel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a59d8b39316079d8edfca962f5202be
https://doi.org/10.1517/13543784.3.8.821
https://doi.org/10.1517/13543784.3.8.821
Autor:
Gregory M. L. Patterson, R. Bonjouklian, Lawrence E. Doolin, Tim A. Smitka, Manuel Debono, S. A. Shaffer, J. B. Stewart, Richard E. Moore, R. M. Molloy
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03d13cd78b20902a7997e958fcab53f5
https://doi.org/10.1002/chin.199202298
https://doi.org/10.1002/chin.199202298
The structures of A10255 B, -G and -J: new thiopeptide antibiotics produced by Streptomyces gardneri
Autor:
Karl Heinz Michel, John L. Occolowitz, Ann H. Hunt, R. Michael Molloy, Jonathan W. Paschal, Manuel Debono, James W. Martin
Publikováno v:
The Journal of Organic Chemistry. 57:5200-5208
The structures of the major members of a new family of important thiopeptide antibiotics, A10255B (1), A10255G (15), and A10255J (16), produced by Streptomyces gardneri (NRRL 15537), are described. Selective chemical degradation in combination with N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e23120670f62262ade5774f7455cb456
https://doi.org/10.1021/jo00045a037
https://doi.org/10.1021/jo00045a037
Autor:
Larry E. Doolin, Tim A. Smitka, Gregory M. L. Patterson, Rosanne Bonjouklian, R. Michael Molloy, Stacey A. Shaffer, Manuel Debono, Jeffrey B. Stewart, Richard E. Moore
Publikováno v:
Tetrahedron. 47:7739-7750
Bioactivity-directed isolation of the extract of the cyanophyte Tolypothrix tjipanasensis has led to the isolation of fifteen new N-glycosides of indolo[2,3-a]carbazoles designated tjipanazoles A1, A2, B, C1, C2, C3, C4, D, E, F1, F2, G1, G2, I and J
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f672093126a28141b49125efcf4e375c
https://doi.org/10.1016/s0040-4020(01)81932-3
https://doi.org/10.1016/s0040-4020(01)81932-3
Publikováno v:
New Approaches for Antifungal Drugs ISBN: 9781489967312
There are two key factors that justify the search for safer and more effective antifungal agents for human medicine. First, the currently available antifungal therapy, especially for life-threatening disseminated fungal infections, is not satisfactor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::160edd8892186409c3d6d15d6815b75c
https://doi.org/10.1007/978-1-4899-6729-9_4
https://doi.org/10.1007/978-1-4899-6729-9_4
Publikováno v:
The Journal of antibiotics. 43(6)
A54145 is a complex of acidic lipopeptide antibiotics produced by Streptomyces fradiae NRRL 18158, NRRL 18159, and NRRL 18160. Each antibiotic factor consists of a peptide core bearing an N-terminal acyl substituent. N-Lys-tert-BOC-protected A54145 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa5ba31348a04268ef2977148d51971
https://pubmed.ncbi.nlm.nih.gov/2380108
https://pubmed.ncbi.nlm.nih.gov/2380108
Autor:
Robert S. Gordee, Manuel Debono
Publikováno v:
Chemotherapy of Fungal Diseases ISBN: 9783642754609
The emergence of immune deficiency diseases, such as AIDS or those that arise from the use of antitumor and organ transplantation regimens, has resulted in major increases in serious fungal infections. Amphotericin B remains the standard treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::710269235ede0f4d5abaf31aad6612c1
https://doi.org/10.1007/978-3-642-75458-6_4
https://doi.org/10.1007/978-3-642-75458-6_4