Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Manuel Boix Chornet"'
Autor:
Boris A. Leibovitch, Janice Murtagh, Kevin Petrie, Eduardo F. Farias, Tino Schenk, Manuel Boix Chornet, Arthur Zelent, Samuel Waxman
Publikováno v:
Proceedings of the National Academy of Sciences. 107:11811-11816
Sin3A/B is a master transcriptional scaffold and corepressor that plays an essential role in the regulation of gene transcription and maintenance of chromatin structure, and its inappropriate recruitment has been associated with aberrant gene silenci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b772a18b9ac07c553f1de590702a59ab
https://doi.org/10.1073/pnas.1006737107
https://doi.org/10.1073/pnas.1006737107
Publikováno v:
Cancer Research. 68:4967-4970
In the past decade, the scientific and medical community has witnessed dramatic progress in epigenetics and has begun to understand some of the epigenetic mechanisms that contribute to human disease, particularly cancer. In January 2007, the third bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b234b7f5a1f84cece1ef029889df496c
https://doi.org/10.1158/0008-5472.can-07-6779
https://doi.org/10.1158/0008-5472.can-07-6779
Autor:
Cristina Largo, Juan Casado, Manuel Boix-Chornet, Antonio Núñez, Rosalia Caballero, J. Ignacio Casal, Luis Franco, Mario F. Fraga, Manel Esteller, Jesús Espada, Ana Villar-Garea, Juan C. Cigudosa, Esteban Ballestar
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Dipòsit Digital de la UB
Universidad de Barcelona
instname
Dipòsit Digital de la UB
Universidad de Barcelona
11 p.-5 fig.-1 fig. supl.
Nuclear events such as chromatin condensation, DNA cleavage at internucleosomal sites, and histone release from chromatin are recognized as hallmarks of apoptosis. However, there is no complete understanding of the mole
Nuclear events such as chromatin condensation, DNA cleavage at internucleosomal sites, and histone release from chromatin are recognized as hallmarks of apoptosis. However, there is no complete understanding of the mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f10a5e076dfe85922efaf7a75180e0
https://doi.org/10.1074/jbc.m601136200
https://doi.org/10.1074/jbc.m601136200
Publikováno v:
Biochemistry. 40:1922-1929
Transglutaminases, the enzymes that catalyze the acyl-transfer reaction between glutamine and primary amines, have been used to introduce probes into proteins in order to perform structural studies using physical techniques. Here we use an original a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbfcd47997d2930d5fe08da9fa50ed46
https://doi.org/10.1021/bi001575b
https://doi.org/10.1021/bi001575b
Autor:
Joan Gil, Llorenç Coll-Mulet, Santiago Ropero, David Otaegui, Fernando P. Cossío, Manel Esteller, María Berdasco, Esteban Ballestar, Alfredo Martínez, Manuel Boix-Chornet, Aizpea Zubia, Mario F. Fraga
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Histone deacetylases (HDACs) play a key role in the regulation of gene expression and chromatin structure, and drugs targeting these enzymes might have an important impact in the treatment of human cancer. Herein, we report the characterization of (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3de476ff9e865f4de501841e301eba
https://pubmed.ncbi.nlm.nih.gov/19169274
https://pubmed.ncbi.nlm.nih.gov/19169274
Autor:
David Grimwade, Kevin Petrie, Tariq Enver, Da Cheng Zhou, Angela N. Barrett, Rajeev Gupta, Arthur Zelent, Guido Hildebrandt, Manuel Boix-Chornet, Samuel Waxman, Robert E. Gallagher, Marieke von Lindern, Annegret Glasow
Publikováno v:
Blood, 111(4), 2374-2377. American Society of Hematology
The retinoic acid receptor (RAR) alpha gene (RARA) encodes 2 major isoforms and mediates positive effects of all-trans retinoic acid (ATRA) on myelomonocytic differentiation. Expression of the ATRA-inducible (RAR alpha 2) isoform increases with myelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e1b3486e4556ffa17f859a4d87e6d4
https://pure.eur.nl/en/publications/4dd8053c-a94d-4ef1-bd49-da0fc5ed11ac
https://pure.eur.nl/en/publications/4dd8053c-a94d-4ef1-bd49-da0fc5ed11ac
Autor:
Rogelio González-Sarmiento, Miguel Alaminos, Fernando Setien, Manuel Boix-Chornet, Lidia Lopez-Serra, Mario F. Fraga, María C. Montoya, Rosalia Caballero, Eva María Sánchez-Tapia, Diego Megías, Manel Esteller, Santiago Ropero, Esteban Ballestar
Publikováno v:
Journal of cell science. 120(Pt 15)
Journal Article; Research Support, Non-U.S. Gov't; The transcription factor Aiolos (also known as IKZF3), a member of the Ikaros family of zinc-finger proteins, plays an important role in the control of B lymphocyte differentiation and proliferation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c6d806b935fba495723b4b6f8fed6e8
https://pubmed.ncbi.nlm.nih.gov/17646674
https://pubmed.ncbi.nlm.nih.gov/17646674
A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition
Autor:
Richard Hamelin, Hiroyuki Yamamoto, Miguel Alaminos, Maria F. Paz, Santiago Ropero, Mario F. Fraga, Manuel Boix-Chornet, Rosalia Caballero, Simó Schwartz, Manel Esteller, Fernando Setien, Torben F. Ørntoft, Diego Arango, Esteban Ballestar, José Palacios, Michel Herranz, Lauri A. Aaltonen
Publikováno v:
Ropero, S, Fraga, MF, Ballestar, E, Hamelin, R, Yamamoto, H, Boix-Chornet, M, Caballero, R, Paz, MF, Herranz, M, Palacios, J, Arango, D, Ørntoft, T F, Aaltonen, LA, Schwartz Jr., S & Esteller, M 2006, ' A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition ', Nature Genetics, vol. 38, no. 5, pp. 566-69 . https://doi.org/10.1038/ng1773
Udgivelsesdato: May Disruption of histone acetylation patterns is a common feature of cancer cells, but very little is known about its genetic basis. We have identified truncating mutations in one of the primary human histone deacetylases, HDAC2, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dea6377cbbe6b4d9276d0a07d6cc7b3
https://pure.au.dk/portal/da/publications/a-truncating-mutation-of-hdac2-in-human-cancers-confers-resistance-to-histone-deacetylase-inhibition(222dd650-0e89-11dc-bee9-02004c4f4f50).html
https://pure.au.dk/portal/da/publications/a-truncating-mutation-of-hdac2-in-human-cancers-confers-resistance-to-histone-deacetylase-inhibition(222dd650-0e89-11dc-bee9-02004c4f4f50).html
Autor:
Manuel Boix-Chornet, Maria Luisa Ballestar, Javier Benitez, Yue Zhong Wu, Emma Carlsson, Manel Esteller, Fernando Setien, Christoph Plass, Mario F. Fraga, Zarko Stephan, Miguel Urioste, Damia Heine-Suñer, Pernille Poulsen, Abel Sánchez-Aguilera, Tim D. Spector, Santiago Ropero, Maria F. Paz, Juan C. Cigudosa, Esteban Ballestar, Charlotte Ling, Allan Vaag
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81acbe547d43dc6518046906b268406c
https://pubmed.ncbi.nlm.nih.gov/16027353
https://pubmed.ncbi.nlm.nih.gov/16027353
Autor:
Amparo Cano, Dolors Colomer, Esteban Ballestar, Carlos Caldas, Enrique Calvo, Axel Imhof, Claire E. Haydon, Ana Villar-Garea, Natalie G. Ahn, Manuel Boix-Chornet, Santiago Ropero, Alberto Pérez-Rosado, Thomas Jenuwein, Jesús Espada, Gunnar Schotta, Miguel A. Piris, N. Gopalakrishna Iyer, María José Calasanz, Kevin Petrie, Tiziana Bonaldi, Juan Antonio López, Mario F. Fraga, Manel Esteller
Publikováno v:
Nature genetics. 37(4)
CpG island hypermethylation and global genomic hypomethylation are common epigenetic features of cancer cells. Less attention has been focused on histone modifications in cancer cells. We characterized post-translational modifications to histone H4 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba605849a53320fc5708dac938f8920
https://pubmed.ncbi.nlm.nih.gov/15765097
https://pubmed.ncbi.nlm.nih.gov/15765097