Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Manuel Blandino-Rosano"'
Autor:
Manuel Blandino-Rosano, Ruy Andrade Louzada, Joao Pedro Werneck-De-Castro, Camila Lubaczeuski, Joana Almaça, Markus A. Rüegg, Michael N. Hall, Gil Leibowitz, Ernesto Bernal-Mizrachi
Publikováno v:
Molecular Metabolism, Vol 75, Iss , Pp 101769- (2023)
Objective: The essential role of raptor/mTORC1 signaling in β-cell survival and insulin processing has been recently demonstrated using raptor knock-out models. Our aim was to evaluate the role of mTORC1 function in adaptation of β-cells to insulin
Externí odkaz:
https://doaj.org/article/492f65d1d70946308c8773653d0f3eef
Autor:
Weiwei Xu, M.M. Fahd Qadir, Daniela Nasteska, Paula Mota de Sa, Caroline M. Gorvin, Manuel Blandino-Rosano, Charles R. Evans, Thuong Ho, Evgeniy Potapenko, Rajakrishnan Veluthakal, Fiona B. Ashford, Stavroula Bitsi, Jia Fan, Manika Bhondeley, Kejing Song, Venkata N. Sure, Siva S.V.P. Sakamuri, Lina Schiffer, Wandy Beatty, Rachael Wyatt, Daniel E. Frigo, Xiaowen Liu, Prasad V. Katakam, Wiebke Arlt, Jochen Buck, Lonny R. Levin, Tony Hu, Jay Kolls, Charles F. Burant, Alejandra Tomas, Matthew J. Merrins, Debbie C. Thurmond, Ernesto Bernal-Mizrachi, David J. Hodson, Franck Mauvais-Jarvis
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112529- (2023)
Summary: Male mice lacking the androgen receptor (AR) in pancreatic β cells exhibit blunted glucose-stimulated insulin secretion (GSIS), leading to hyperglycemia. Testosterone activates an extranuclear AR in β cells to amplify glucagon-like peptide
Externí odkaz:
https://doaj.org/article/557572b83b5a4a7ca84c9f23c0810f39
Autor:
Manuel Blandino-Rosano, Rebecca Barbaresso, Margarita Jimenez-Palomares, Nadejda Bozadjieva, Joao Pedro Werneck-de-Castro, Masayuki Hatanaka, Raghavendra G. Mirmira, Nahum Sonenberg, Ming Liu, Markus A. Rüegg, Michael N. Hall, Ernesto Bernal-Mizrachi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Deregulation of mTORC1 pathway has been associated with several human diseases including diabetes, neurodegeneration and cancer. Here Blandino-Rosanoet al. show that mTORC1 signalling controls insulin secretion and β-cell maintenance by regulation o
Externí odkaz:
https://doaj.org/article/effc74d97aa34c3f83d6c968e3443703
Autor:
Lynda Elghazi, Manuel Blandino-Rosano, Emilyn Alejandro, Corentin Cras-Méneur, Ernesto Bernal-Mizrachi
Publikováno v:
Molecular Metabolism, Vol 6, Iss 6, Pp 560-573 (2017)
Objective: Poor fetal nutrition increases the risk of type 2 diabetes in the offspring at least in part by reduced embryonic β-cell growth and impaired function. However, it is not entirely clear how fetal nutrients and growth factors impact β-cell
Externí odkaz:
https://doaj.org/article/2cf8038ec3b7439e8b8d72afbae86ca0
Autor:
Dora M. Berman, Phillip Ruiz, Manuel Blandino-Rosano, Ernesto Bernal-Mizrachi, Norma S. Kenyon
Publikováno v:
Cell Transplantation, Vol 28 (2019)
The need for chronic immune suppression (IS) is one of the hurdles precluding widespread use of islet cell transplantation to restore glycemic control in patients with type 1 diabetes. We report the case of a healthy nonhuman primate (NHP) treated on
Externí odkaz:
https://doaj.org/article/53e91a5ff6654eabae159b2c40054c89
Autor:
Laura Quintana-Lopez, Manuel Blandino-Rosano, Gonzalo Perez-Arana, Alberto Cebada-Aleu, Alfonso Lechuga-Sancho, Manuel Aguilar-Diosdado, Carmen Segundo
Publikováno v:
Mediators of Inflammation, Vol 2013 (2013)
Nitric oxide (NO) is involved in several biological processes. In type 1 diabetes mellitus (T1DM), proinflammatory cytokines activate an inducible isoform of NOS (iNOS) in β cells, thus increasing NO levels and inducing apoptosis. The aim of the cur
Externí odkaz:
https://doaj.org/article/c1617c83ad3e4da8a1332267b9c855ca
Autor:
PAULA MOTA DE SA, MIRZA MUHAMMAD FAHD QADIR, MANUEL BLANDINO-ROSANO, JIA FAN, WEIWEI XU, ERNESTO BERNAL-MIZRACHI, FRANCK MAUVAIS-JARVIS
Publikováno v:
Diabetes. 71
Male mice lacking the androgen receptor (AR) in islet β cells exhibit blunted glucose-stimulated insulin secretion (GSIS) , leading to hypoinsulinemia and hyperglycemia. We showed that dihydrotestosterone (DHT) activation of an extranuclear AR in β
Autor:
Manuel Blandino-Rosano, Joshua O. Scheys, Joao Pedro Werneck-de-Castro, Ruy A. Louzada, Joana Almaça, Gil Leibowitz, Markus A. Rüegg, Michael N. Hall, Ernesto Bernal-Mizrachi
Mammalian target of rapamycin (mTOR) kinase is an essential hub where nutrients and growth factors converge to control cellular metabolism. mTOR interacts with different accessory proteins to form complexes 1 and 2 (mTORC), and each complex has diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37195ff720b5b01918fa4782257d0d4
Autor:
Weiwei Xu, Fahd Qadir, Daniela Nasteska, Paula Mota de Sa, Caroline M. Gorvin, Manuel Blandino-Rosano, Charles R. Evans, Fiona B. Ashford, Stavroula Bitsi, Jia Fan, Manika Bhondeley, Kejing Song, Venkata N. Sure, Lina Schiffer, Wandy Beatty, Rachael Wyatt, Daniel E. Frigo, Xiaowen Liu, Prasad V. Katakam, Wiebke Arlt, Jochen Buck, Lonny R. Levin, Tony Hu, Jay Kolls, Charles F. Burant, Alejandra Tomas, Ernesto Bernal-Mizrachi, David Hodson, Franck Mauvais-Jarvis
Publikováno v:
SSRN Electronic Journal.
Autor:
Gil Leibowitz, Ernesto Bernal-Mizrachi, Erol Cerasi, Boaz Tirosh, Orly Agmon, Nitzan Israeli, Gilad Hacker, Sharona Tornovsky-Babeay, Liat Kadosh, Roni Yeroslaviz-Stolper, Manuel Blandino-Rosano, Joao Pedro Werneck-de-Castro, Ruy Andrade Louzada, Perla Garzon, Yael Riahi, Tal Israeli
The dynamic regulation of autophagy in b-cells by cycles of fasting-feeding and its effects on insulin secretion are unknown. In b-cells mTORC1 is inhibited while fasting, and is rapidly stimulated during refeeding by a single amino acid, leucine, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1717c0262c0540eaad7c4a2ca4bcf346
https://doi.org/10.2337/figshare.17099846.v1
https://doi.org/10.2337/figshare.17099846.v1