Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Manuel Adrian Suter"'
Autor:
Manuel Adrian Suter, Nikki Y. Tan, Chung Hwee Thiam, Muznah Khatoo, Paul A. MacAry, Veronique Angeli, Stephan Gasser, Y. L. Zhang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Deficiencies in DNA repair and DNA degrading nucleases lead to accumulation of cytosolic DNA. cGAS is a critical DNA sensor for the detection of cytosolic DNA and subsequent activation of the STING signaling pathway. Here, we show that the c
Externí odkaz:
https://doaj.org/article/79ec77f2ebf949149c0b66f12a1493ef
Autor:
Stephan Gasser, Chung Hwee Thiam, Paul A. MacAry, Muznah Khatoo, Manuel Adrian Suter, Veronique Angeli, Yajun Zhang, Nikki Y. Tan
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Deficiencies in DNA repair and DNA degrading nucleases lead to accumulation of cytosolic DNA. cGAS is a critical DNA sensor for the detection of cytosolic DNA and subsequent activation of the STING signaling pathway. Here, we show that the cGAS-STING
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d8c6ab5622d955903c2b7c8a16fe69
https://doi.org/10.1038/s41598-021-86644-x
https://doi.org/10.1038/s41598-021-86644-x
Autor:
Manuel Adrian Suter, Wendy Y.L. Zhang, Muznah Khatoo, Veronique Angeli, Nikki Y. Tan, Paul A. MacAry, Stephan Gasser
Publikováno v:
SSRN Electronic Journal.
Deficiencies in DNA repair and DNA degrading nucleases can lead to accumulation of cytosolic DNA and the activation of STING pathways in tumor cells. The DNA sensors that recognize cytosolic DNA in tumor cells are not known. Here we show that double-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca9e160b174fb2287632a12fe67839f1
https://doi.org/10.2139/ssrn.3559534
https://doi.org/10.2139/ssrn.3559534
Autor:
Manuel Adrian Suter, Nicholas R. J. Gascoigne, Chien Tei Too, Min Zin Oo, Conrad E.Z. Chan, Junyun Lai, Wei Jian Tan, Andrew Guo Xian Lim, Brendon J. Hanson, Soh Ha Chan, Joanna Ai Ling Choo, Paul A. MacAry, Fatimah Bte Mustafa, Nalini Srinivasan, Youjia Zhong
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Epstein-Barr virus (EBV) is a common gammaherpesvirus associated with various human malignancies. Antibodies with T cell receptor-like specificities (TCR-like mAbs) provide a means to target intracellular tumor- or virus-associated antigens by recogn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e5a0826188fdc3947ea66c6b0c327a
https://pubmed.ncbi.nlm.nih.gov/28855662
https://pubmed.ncbi.nlm.nih.gov/28855662
Autor:
Wendy Y.L. Zhang, Chien Tei Too, Shubhita Tripathi, Nikki Ya Ling Tan, Stephan Gasser, Manuel Adrian Suter, Veronique Angeli, Muznah Khatoo, Paul A. MacAry
Publikováno v:
Cancer Immunology Research. 7:B189-B189
Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that catalyses the synthesis of cGAMP, which serves as a ligand for stimulator of interferon (IFN) genes (STING). Activation of STING results in production of type I IFNs through phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b7c3487dbc2c5d6c65fb11c7550ce40
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b189
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b189
Autor:
Florence S.G. Cheung, Nikki Y. Tan, Shubhita Tripathi, Manuel Adrian Suter, Muznah Khatoo, Zhi Huan Chew, Stephan Gasser, Joanne Ngeow, Wendy Y.L. Zhang
Publikováno v:
Mechanisms of ageing and development. 165
The presence of damaged and microbial DNA can pose a threat to the survival of organisms. Cells express various sensors that recognize specific aspects of such potentially dangerous DNA. Recognition of damaged or microbial DNA by sensors induces cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6c1b911851bb909e5129487579052b
https://pubmed.ncbi.nlm.nih.gov/27614000
https://pubmed.ncbi.nlm.nih.gov/27614000
Autor:
Priya Ragunathan, Gerhard Grüber, Goran Biuković, Thomas Dick, Manuel Adrian Suter, Adam Hotra, Subhashri Kundu
The F1FO-ATP synthase is one of the enzymes that is essential to meet the energy requirement of both the proliferating aerobic and hypoxic dormant stages of the life cycle of mycobacteria. Most F-ATP synthases consume ATP in the α3:β3 headpiece to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18790fe0e6347957e40be8a1dcbb6003
http://hdl.handle.net/10220/41395
http://hdl.handle.net/10220/41395
Autor:
Manuel Adrian Suter, Puay Hoon Tan, Muznah Khatoo, Nikki Y. Tan, Florence S.G. Cheung, Samantha S.W. Ho, Wendy Y.L. Zhang, Shubhita Tripathi, Stephan Gasser, Joanne Ngeow, Weng Khong Lim
Publikováno v:
Immunity. 44(5)
Self-DNA is present in the cytosol of many cancer cells and can promote effective immune rejection of tumor cells, but the mechanisms leading to the presence of cytosolic DNA are unknown. Here, we report that the cleavage of genomic DNA by DNA struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904fb55ff86d7a2ec170bc9f295686de
https://pubmed.ncbi.nlm.nih.gov/27178469
https://pubmed.ncbi.nlm.nih.gov/27178469