Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Manuel A. F. V. Gonçalves"'
Autor:
Jin Ma, Gerard van der Zon, Manuel A. F. V. Gonçalves, Maarten van Dinther, Midory Thorikay, Gonzalo Sanchez-Duffhues, Peter ten Dijke
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Endothelial-to-mesenchymal transition (EndMT) plays an important role in embryonic development and disease progression. Yet, how different members of the transforming growth factor-β (TGF-β) family regulate EndMT is not well understood. In the curr
Externí odkaz:
https://doaj.org/article/914b74b0d1ba4c118ce6cd0e59ac3223
Autor:
Hidde A. Zittersteijn, Cornelis L. Harteveld, Stefanie Klaver-Flores, Arjan C. Lankester, Rob C. Hoeben, Frank J. T. Staal, Manuel A. F. V. Gonçalves
Publikováno v:
Frontiers in Genome Editing, Vol 2 (2021)
Throughout the past decades, the search for a treatment for severe hemoglobinopathies has gained increased interest within the scientific community. The discovery that ɤ-globin expression from intact HBG alleles complements defective HBB alleles und
Externí odkaz:
https://doaj.org/article/1ec3b51aef664078b3953fc7d4181d30
Autor:
Stefanie Klaver-Flores, Hidde A. Zittersteijn, Kirsten Canté-Barrett, Arjan Lankester, Rob C. Hoeben, Manuel A. F. V. Gonçalves, Karin Pike-Overzet, Frank J. T. Staal
Publikováno v:
Frontiers in Genome Editing, Vol 2 (2021)
Many gene editing techniques are developed and tested, yet, most of these are optimized for transformed cell lines, which differ from their primary cell counterparts in terms of transfectability, cell death propensity, differentiation capability, and
Externí odkaz:
https://doaj.org/article/7a6d9e16d2b64173a90841ea44ea4661
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Inherited retinal diseases encompass a highly heterogenous group of disorders caused by a wide range of genetic variants and with diverse clinical symptoms that converge in the common trait of retinal degeneration. Indeed, mutations in over 270 genes
Externí odkaz:
https://doaj.org/article/8474676379514e4496aebbf0b5ad65b0
Autor:
Xiaoyu Chen, Josephine M. Janssen, Jin Liu, Ignazio Maggio, Anke E. J. ‘t Jong, Harald M.M. Mikkers, Manuel A. F. V. Gonçalves
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
CRISPR-Cas9-based gene editing involves double-strand breaks at target sequences, which are often repaired by mutagenic non-homologous end-joining. Here the authors use Cas9 nickases to generate coordinated single-strand breaks in donor and target DN
Externí odkaz:
https://doaj.org/article/60102009427545b88a37146eedf8137c
Publikováno v:
Cells, Vol 9, Iss 4, p 869 (2020)
Duchenne muscular dystrophy (DMD) is a fatal X-linked muscle wasting disorder arising from mutations in the ~2.4 Mb dystrophin-encoding DMD gene. RNA-guided CRISPR-Cas9 nucleases (RGNs) are opening new DMD therapeutic routes whose bottlenecks include
Externí odkaz:
https://doaj.org/article/c5a32dfddf4a4d22a011e3bee605c29b
Autor:
Anabel S. De La Garza-Rodea, Ietje Van Der Velde-Van Dijke, Hester Boersma, Manuel A. F. V. Gonçalves, Dirk W. Van Bekkum, Antoine A. F. De Vries, Shoshan Knaän-Shanzer Ph.D.
Publikováno v:
Cell Transplantation, Vol 21 (2012)
Mesenchymal stem cells (MSCs) of mammals have been isolated from many tissues and are characterized by their aptitude to differentiate into bone, cartilage, and fat. Differentiation into cells of other lineages like skeletal muscle, tendon/ligament,
Externí odkaz:
https://doaj.org/article/8f9ed5c6084b4981ada4550ce7f13659
Autor:
Anabel S. De La Garza-Rodea, Ietje Van Der Velde, Hester Boersma, Manuel A. F. V. Gonçalves, Dirk W. Van Bekkum, Antoine A. F. De Vries, Shoshan Knaän-Shanzer Ph.D.
Publikováno v:
Cell Transplantation, Vol 20 (2011)
Mesenchymal stromal cells (MSCs) are attractive for cellular therapy of muscular dystrophies as they are easy to procure, can be greatly expanded ex vivo, and contribute to skeletal muscle repair in vivo. However, detailed information about the contr
Externí odkaz:
https://doaj.org/article/032f4e397aa242b5aa0ed6bba3c24b9c
Publikováno v:
Journal of Inherited Metabolic Disease
Journal of Inherited Metabolic Disease, 44(1), 54-71. WILEY
Journal of Inherited Metabolic Disease, 44(1), 54-71. WILEY
Genetic therapies based on gene addition have witnessed a variety of clinical successes and the first therapeutic products have been approved for clinical use. Moreover, innovative gene editing techniques are starting to offer new opportunities in wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c5d2a4e981d279a709f99ce275fe59
http://europepmc.org/articles/PMC7891367
http://europepmc.org/articles/PMC7891367
Autor:
Manuel A F V Gonçalves
Publikováno v:
Cell and Gene Therapy Insights. 6:427-435
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa4175bdfa6fdd6a25aebfa245008e99
https://doi.org/10.18609/cgti.2020.051
https://doi.org/10.18609/cgti.2020.051