Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Manuel A S Santos"'
Autor:
Rui Marçalo, Sonya Neto, Miguel Pinheiro, Ana J Rodrigues, Nuno Sousa, Manuel A S Santos, Paula Simão, Carla Valente, Lília Andrade, Alda Marques, Gabriela R Moura
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0264009 (2022)
BackgroundPopulations seem to respond differently to the global pandemic of severe acute respiratory syndrome coronavirus 2. Recent studies show individual variability in both susceptibility and clinical response to COVID-19 infection. People with ch
Externí odkaz:
https://doaj.org/article/76f7304af13d4cb3b38edef8db0cef6a
Autor:
Marta Cela, Caroline Paulus, Manuel A S Santos, Gabriela R Moura, Magali Frugier, Joëlle Rudinger-Thirion
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209805 (2018)
The life cycle of Plasmodium falciparum, the agent responsible for malaria, depends on both cytosolic and apicoplast translation fidelity. Apicoplast aminoacyl-tRNA synthetases (aaRS) are bacterial-like enzymes devoted to organellar tRNA aminoacylati
Externí odkaz:
https://doaj.org/article/e14951447aab4e6da6d95cfadfba7229
Autor:
Ana Rita D Araújo, Tânia Melo, Elisabete A Maciel, Clara Pereira, Catarina M Morais, Deolinda R Santinha, Joana F Tavares, Helena Oliveira, Amália S Jurado, Vítor Costa, Pedro Domingues, Maria Rosário M Domingues, Manuel A S Santos
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202402 (2018)
The occurrence of protein synthesis errors (mistranslation) above the typical mean mistranslation level of 10-4 is mostly deleterious to yeast, zebrafish and mammal cells. Previous yeast studies have shown that mistranslation affects fitness and dere
Externí odkaz:
https://doaj.org/article/8b8644d1a9534d26a9aba008f23aac0c
Autor:
Zoltán Bódi, Zoltán Farkas, Dmitry Nevozhay, Dorottya Kalapis, Viktória Lázár, Bálint Csörgő, Ákos Nyerges, Béla Szamecz, Gergely Fekete, Balázs Papp, Hugo Araújo, José L Oliveira, Gabriela Moura, Manuel A S Santos, Tamás Székely, Gábor Balázsi, Csaba Pál
Publikováno v:
PLoS Biology, Vol 15, Iss 6, p e1002607 (2017)
[This corrects the article DOI: 10.1371/journal.pbio.2000644.].
Externí odkaz:
https://doaj.org/article/bae5ab0467af40af8e6103f70de1b9ab
Autor:
Zoltán Bódi, Zoltán Farkas, Dmitry Nevozhay, Dorottya Kalapis, Viktória Lázár, Bálint Csörgő, Ákos Nyerges, Béla Szamecz, Gergely Fekete, Balázs Papp, Hugo Araújo, José L Oliveira, Gabriela Moura, Manuel A S Santos, Tamás Székely, Gábor Balázsi, Csaba Pál
Publikováno v:
PLoS Biology, Vol 15, Iss 5, p e2000644 (2017)
Genetically identical cells frequently display substantial heterogeneity in gene expression, cellular morphology and physiology. It has been suggested that by rapidly generating a subpopulation with novel phenotypic traits, phenotypic heterogeneity (
Externí odkaz:
https://doaj.org/article/8aa0f60a3d4b4da2b53a6c14ac85d68f
Autor:
Sonya Neto, Andreia Reis, Miguel Pinheiro, Margarida Ferreira, Vasco Neves, Teresa Costa Castanho, Nadine Santos, Ana João Rodrigues, Nuno Sousa, Manuel A. S. Santos, Gabriela R. Moura
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-16 (2024)
Abstract Background Aging represents a significant risk factor for the occurrence of cerebral small vessel disease, associated with white matter (WM) lesions, and to age-related cognitive alterations, though the precise mechanisms remain largely unkn
Externí odkaz:
https://doaj.org/article/2e0c7763ac12478f9c1753c74e574d65
Autor:
Dorottya Kalapis, Ana R Bezerra, Zoltán Farkas, Peter Horvath, Zoltán Bódi, Andreea Daraba, Béla Szamecz, Ivo Gut, Mónica Bayes, Manuel A S Santos, Csaba Pál
Publikováno v:
PLoS Biology, Vol 13, Iss 11, p e1002291 (2015)
Translational errors occur at high rates, and they influence organism viability and the onset of genetic diseases. To investigate how organisms mitigate the deleterious effects of protein synthesis errors during evolution, a mutant yeast strain was e
Externí odkaz:
https://doaj.org/article/a233480ffc9f4770aea9f2fdf57f35a0
Autor:
Gabriela R Moura, Miguel Pinheiro, Adelaide Freitas, José L Oliveira, Jörg C Frommlet, Laura Carreto, Ana R Soares, Ana R Bezerra, Manuel A S Santos
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145593 (2015)
Externí odkaz:
https://doaj.org/article/6fa0225e6a6f47e189e1438db1333b1f
Autor:
Joana Fernandes, Marta Vieira, Laura Carreto, Manuel A S Santos, Carlos B Duarte, Ana Luísa Carvalho, Armanda E Santos
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99958 (2014)
Transient global cerebral ischemia induces profound changes in the transcriptome of brain cells, which is partially associated with the induction or repression of genes that influence the ischemic response. However, the mechanisms responsible for the
Externí odkaz:
https://doaj.org/article/41418ec81e704b429a92dce15ed2230f
Autor:
Telma Quintela, Isabel Gonçalves, Laura C Carreto, Manuel A S Santos, Helena Marcelino, Filipa M Patriarca, Cecília R A Santos
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60199 (2013)
The choroid plexus (CP) are highly vascularized branched structures that protrude into the ventricles of the brain, and form a unique interface between the blood and the cerebrospinal fluid (CSF), the blood-CSF barrier, that are the main site of prod
Externí odkaz:
https://doaj.org/article/029505caeb50459e929241bfd82fbed0