Výsledky vyhledávání - "Manuel A Fernandez-Rojo"

Akademický článek

Caveolin-1 deficiency leads to increased susceptibility to cell death and fibrosis in white adipose tissue: characterization of a lipodystrophic model.

Autor: Sally Martin, Manuel A Fernandez-Rojo, Amanda C Stanley, Michele Bastiani, Satomi Okano, Susan J Nixon, Gethin Thomas, Jennifer L Stow, Robert G Parton

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e46242 (2012)

Caveolin-1 (CAV1) is an important regulator of adipose tissue homeostasis. In the present study we examined the impact of CAV1 deficiency on the properties of mouse adipose tissue both in vivo and in explant cultures during conditions of metabolic st

Externí odkaz: https://doaj.org/article/ebdfa0414c6548d086faa36ff88e38fa

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Akademický článek

Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research

Publikováno v: iScience, Vol 26, Iss 9, Pp 107289- (2023)

Summary: Following on from the NASA twins’ study, there has been a tremendous interest in the use of omics techniques in spaceflight. Individual space agencies, NASA’s GeneLab, JAXA's ibSLS, and the ESA-funded Space Omics Topical Team and the Int

Externí odkaz: https://doaj.org/article/3031f2fe08944d85a84de26b43157091

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Akademický článek

Malaysian and Chinese King Cobra Venom Cytotoxicity in Melanoma and Neonatal Foreskin Fibroblasts Is Mediated by Age and Geography

Autor: Bianca Op den Brouw, Manuel A. Fernandez-Rojo, Tom Charlton, Bryan G. Fry, Maria P. Ikonomopoulou

Publikováno v: Toxins, Vol 15, Iss 9, p 549 (2023)

Snake venoms constitute a complex, rapidly evolving trait, whose composition varies between and within populations depending on geographical location, age and preys (diets). These factors have determined the adaptive evolution for predatory success a

Externí odkaz: https://doaj.org/article/dc87d7305c3948069d2b89dffc1e8ebb

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Akademický článek

Space omics research in Europe: Contributions, geographical distribution and ESA member state funding schemes

Publikováno v: iScience, Vol 25, Iss 3, Pp 103920- (2022)

Summary: The European research community, via European Space Agency (ESA) spaceflight opportunities, has significantly contributed toward our current understanding of spaceflight biology. Recent molecular biology experiments include “omic” analys

Externí odkaz: https://doaj.org/article/75476c8e52554678a83c295c7eabf288

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Akademický článek

Extensive Variation in the Activities of Pseudocerastes and Eristicophis Viper Venoms Suggests Divergent Envenoming Strategies Are Used for Prey Capture

Autor: Bianca op den Brouw, Francisco C. P. Coimbra, Lachlan A. Bourke, Tam Minh Huynh, Danielle H. W. Vlecken, Parviz Ghezellou, Jeroen C. Visser, James S. Dobson, Manuel A. Fernandez-Rojo, Maria P. Ikonomopoulou, Nicholas R. Casewell, Syed A. Ali, Behzad Fathinia, Wayne C. Hodgson, Bryan G. Fry

Publikováno v: Toxins, Vol 13, Iss 2, p 112 (2021)

Snakes of the genera Pseudocerastes and Eristicophis (Viperidae: Viperinae) are known as the desert vipers due to their association with the arid environments of the Middle East. These species have received limited research attention and little is kn

Externí odkaz: https://doaj.org/article/12764346280e4a0892f4a23f97607752

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Akademický článek

ERK and mTORC1 Inhibitors Enhance the Anti-Cancer Capacity of the Octpep-1 Venom-Derived Peptide in Melanoma BRAF(V600E) Mutations

Autor: Javier Moral-Sanz, Manuel A. Fernandez-Rojo, Jeremy Potriquet, Pamela Mukhopadhyay, Andreas Brust, Patrick Wilhelm, Taylor B. Smallwood, Richard J. Clark, Bryan G. Fry, Paul F. Alewood, Nicola Waddell, John J. Miles, Jason P. Mulvenna, Maria P. Ikonomopoulou

Publikováno v: Toxins, Vol 13, Iss 2, p 146 (2021)

Melanoma is the main cause of skin cancer deaths, with special emphasis in those cases carrying BRAF mutations that trigger the mitogen-activated protein kinases (MAPK) signaling and unrestrained cell proliferation in the absence of mitogens. Current

Externí odkaz: https://doaj.org/article/d572031b4c944e80bb5752ab41c73b67

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Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy, Allowing Liver Regeneration and Survival Through Induction of H2‐Bl/HLA‐G

Autor: Viral Chikani, Shiro Minami, Michael J. Waters, Ken K. Y. Ho, Jamie Rossjohn, Andrew J. Brooks, Grant A. Ramm, Kathryn A. Tunny, Johan Medina, Robert G. Parton, Mayumi Ishikawa, Manuel A. Fernandez-Rojo, Julian P. Vivian, Yash Chhabra

Publikováno v: Hepatology (Baltimore, Md.)

Background and Aims Growth hormone (GH) is important for liver regeneration after partial hepatectomy (PHx). We investigated this process in C57BL/6 mice that express different forms of the GH receptor (GHR) with deletions in key signaling domains. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f861bebfa4a8605b37635db4d77c6e8
https://doi.org/10.1002/hep.31297

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Supersonic shear-wave elastography and APRI for the detection and staging of liver disease in pediatric cystic fibrosis

Autor: Peter Lewindon, Miranda A. Coleman, Louise E. Ramm, Grant A. Ramm, Manuel A. Fernandez-Rojo, Fariha Balouch, Gunter Hartel, Diego A. Calvopina, Charlton Noble, Anna Weis

Publikováno v: Journal of Cystic Fibrosis. 19:449-454

Current diagnostic methods for the diagnosis of Cystic fibrosis (CF)-associated liver disease (CFLD) are non-specific and assessment of disease progression is difficult prior to the advent of advanced disease with portal hypertension. This study inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25aace169fdd1f22aa18e9009f1756c
https://doi.org/10.1016/j.jcf.2019.06.017

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