Network heterogeneity regulates steering in actin-based motility

Autor: Rajaa Boujemaa-Paterski, Cristian Suarez, Tobias Klar, Jie Zhu, Christophe Guérin, Alex Mogilner, Manuel Théry, Laurent Blanchoin

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Protrusive cellular structures contain a heterogeneous density of actin, but whether this influences motility is not known. Using an in vitro system and modelling, here the authors show that local actin monomer depletion and network architecture can

Externí odkaz: https://doaj.org/article/64331f5cf12f4e7b9dc3f3a2a8b59e8b

Actin nucleation at the centrosome controls lymphocyte polarity

Autor: Dorian Obino, Francesca Farina, Odile Malbec, Pablo J. Sáez, Mathieu Maurin, Jérémie Gaillard, Florent Dingli, Damarys Loew, Alexis Gautreau, Maria-Isabel Yuseff, Laurent Blanchoin, Manuel Théry, Ana-Maria Lennon-Duménil

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

Cell polarity is marked by re-orientation of the centrosome, but the mechanisms governing centrosome polarization are poorly understood. Here Obino et al. show that in lymphocytes centrosome-associated Arp2/3 nucleates actin that tethers the centroso

Externí odkaz: https://doaj.org/article/ad0cead5d3e646b58ced0f3632298203

Friction patterns guide actin network contraction

Autor: Alexandra Colin, Magali Orhant-Prioux, Christophe Guérin, Mariya Savinov, Ilaria Scarfone, Aurelien Roux, Enrique M. De La Cruz, Alex Mogilner, Manuel Théry, Laurent Blanchoin

The shape of cells is the outcome of the balance of inner forces produced by the actomyosin network and the resistive forces produced by cell adhesion to their environment. The specific contributions of contractile, anchoring and friction forces to n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6b3214b6be35b2ce4f10224c53c0d7a
https://doi.org/10.1101/2022.12.21.521384

Actin–microtubule dynamic composite forms responsive active matter with memory

Autor: Ondřej Kučera, Jérémie Gaillard, Christophe Guérin, Manuel Théry, Laurent Blanchoin

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (31), pp.e2209522119. ⟨10.1073/pnas.2209522119⟩

Active cytoskeletal materials in vitro demonstrate self-organising properties similar to those observed in their counterparts in cells. However, the search to emulate phenomena observed in the living matter has fallen short of producing a cytoskeleta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6022f908e460ea87fa959dbf94dd45ea
https://hal.science/hal-03747735

Actin network architecture can ensure robust centering or sensitive decentering of the centrosome

Autor: Shohei Yamamoto, Jérémie Gaillard, Benoit Vianay, Christophe Guerin, Magali Orhant‐Prioux, Laurent Blanchoin, Manuel Théry

Publikováno v: EMBO Journal
EMBO Journal, 2022, 41 (20), pp.e111631. ⟨10.15252/embj.2022111631⟩

International audience; The orientation of cell polarity depends on the position of the centrosome, the main microtubule-organizing center (MTOC). Microtubules (MTs) transmit pushing forces to the MTOC as they grow against the cell periphery. How the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57cdbb00476b0aa95c29545dabf60c7
https://pubmed.ncbi.nlm.nih.gov/35916262