Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Manuel, Hilbert"'
Autor:
Simon Arnoldini, Alessandra Moscaroli, Mamta Chabria, Manuel Hilbert, Samuel Hertig, Roger Schibli, Martin Béhé, Viola Vogel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The extracellular matrix is under variable strain, but we lack the tools to detect differences in strain. Here the authors develop a probe based on a bacterial fibronectin-binding peptide that binds to relaxed fibronectin fibrils and detects relaxed
Externí odkaz:
https://doaj.org/article/8af98124e0cc41929238a7f5cc43757f
Autor:
Yingfang He, Uwe Grether, Marco F. Taddio, Carla Meier, Claudia Keller, Martin R. Edelmann, Michael Honer, Sylwia Huber, Matthias B. Wittwer, Dominik Heer, Hans Richter, Ludovic Collin, Melanie N. Hug, Manuel Hilbert, Annemarieke G.J. Postmus, Anna Floor Stevens, Mario van der Stelt, Stefanie D. Krämer, Roger Schibli, Linjing Mu, Luca C. Gobbi
Publikováno v:
European Journal of Medicinal Chemistry, 243:114750. ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
European Journal of Medicinal Chemistry, 243
European Journal of Medicinal Chemistry, 243
Monoacylglycerol lipase (MAGL) is a gatekeeper in regulating endocannabinoid signaling and has gained substantial attention as a therapeutic target for neurological disorders. We recently discovered a morpholin-3-one derivative as a novel scaffold fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3c55a40e57837b88082305c6a4d833
https://doi.org/10.1016/j.ejmech.2022.114750
https://doi.org/10.1016/j.ejmech.2022.114750
Autor:
Nicola J. Dynes, Sarah Bianchi, Michel O. Steinmetz, Pierre Gönczy, Manuel Hilbert, Ioannis Vakonakis, Kacper B. Rogala, Sebastian A. Leidel
Publikováno v:
Molecular Biology of the Cell. 29:722-735
Centrioles are microtubule-based organelles that organize the microtubule network and seed the formation of cilia and flagella. New centrioles assemble through a stepwise process dependent notably on the centriolar protein SAS-5 in Caenorhabditis ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2eb5238604f2bebbe81dfae09fe8870
https://doi.org/10.1091/mbc.e17-06-0412
https://doi.org/10.1091/mbc.e17-06-0412
Autor:
Manuel Hilbert, Tessa Lühmann, Alessandra Moscaroli, Eliane Fischer, Gabriel Jones, Stephanie Wälti, Martin Béhé, Alain Blanc, Lorenz Meinel, Roger Schibli
Publikováno v:
Molecular Pharmaceutics. 14:639-648
Fibroblast growth factor-2 (FGF-2) is a potent modulator of cell growth and regulation, with improper FGF-2 signaling being involved in impaired responses to injury or even cancer. Therefore, the exploitation of FGF-2 as a therapeutic drives the prer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2280938ab8fecdea01c2193262a19c1f
https://doi.org/10.1021/acs.molpharmaceut.6b00913
https://doi.org/10.1021/acs.molpharmaceut.6b00913
Autor:
Manuel Hilbert, Serena Lunardi, Alberto Ortega, Tamara Maes, Cristina Mascaró, Raquel Ruiz Rodriguez, Li Yu, Elena Carceller, Filippo Ciceri
Screening of cellular activity for inhibitors of histone lysine modifiers is most frequently performed indirectly by analyzing changes in the total levels of histone marks targeted by lysine methylases/demethylases. However, inhibition of histone lys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f7218d6f634c82a65a58388d4a3b0c
https://europepmc.org/articles/PMC6527171/
https://europepmc.org/articles/PMC6527171/
Autor:
Natacha Olieric, Georgios N. Hatzopoulos, Paul Guichard, Jagan M. Obbineni, Pierre Gönczy, Michel O. Steinmetz, John Missimer, Sebastian H. W. Kraatz, Manuel Hilbert, Indrani Sen
Publikováno v:
Structure
Centrioles are microtubule-based structures that play important roles notably in cell division and cilium biogenesis. CEP135/Bld10p family members are evolutionarily conserved microtubule-binding proteins important for centriole formation. Here, we a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93203c9ad225cc21cc95fc72414d3720
https://doi.org/10.1016/j.str.2016.06.011
https://doi.org/10.1016/j.str.2016.06.011
Autor:
Michel O. Steinmetz, Pierre Gönczy, Virginie Hamel, Rolf Jaussi, Isabelle Flückiger, Masafumi Hirono, Sebastian H. W. Kraatz, Sarah Hosner, Daniel Frey, Katherine M. Thieltges, Xavier Deupi, Paul Guichard, Daniel J. Müller, Moritz Pfreundschuh, Akira Noga, Mara M. Wieser, Richard A. Kammerer, Manuel Hilbert
Publikováno v:
Nature Cell Biology
Centrioles are critical for the formation of centrosomes, cilia and flagella in eukaryotes. They are thought to assemble around a nine-fold symmetric cartwheel structure established by SAS-6 proteins. Here, we have engineered Chlamydomonas reinhardti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef82172672d9f69e89f0925b786f2e85
https://doi.org/10.1038/ncb3329
https://doi.org/10.1038/ncb3329
Autor:
Sarah, Bianchi, Kacper B, Rogala, Nicola J, Dynes, Manuel, Hilbert, Sebastian A, Leidel, Michel O, Steinmetz, Pierre, Gönczy, Ioannis, Vakonakis
Publikováno v:
Molecular biology of the cell. 29(6)
Centrioles are microtubule-based organelles that organize the microtubule network and seed the formation of cilia and flagella. New centrioles assemble through a stepwise process dependent notably on the centriolar protein SAS-5 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d195dc7951c3b871cbeb35aa72405e50
https://pubmed.ncbi.nlm.nih.gov/29367435
https://pubmed.ncbi.nlm.nih.gov/29367435
Publikováno v:
Nano Letters
Simultaneous high-resolution imaging and localization of chemical interaction sites on single native proteins is a pertinent biophysical, biochemical, and nanotechnological challenge. Such structural mapping and characterization of binding sites is o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6fffa07313519472bf17083f811f5d5
https://doi.org/10.1021/nl5012905
https://doi.org/10.1021/nl5012905
Autor:
Simon Arnoldini, Manuel Hilbert, Roger Schibli, Martin Béhé, Viola Vogel, Samuel Hertig, Alessandra Moscaroli, Mamta Chabria
Publikováno v:
Nature Communications
Nature Communications, 8 (1)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, 8 (1)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Transformations of extracellular matrix (ECM) accompany pathological tissue changes, yet how cell-ECM crosstalk drives these processes remains unknown as adequate tools to probe forces or mechanical strains in tissues are lacking. Here, we introduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc855c4d71872f35a2ded72da8ac537
https://pubmed.ncbi.nlm.nih.gov/29176724
https://pubmed.ncbi.nlm.nih.gov/29176724