Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Manuchair Ebadi"'
Autor:
Manuchair Ebadi, Sushil Sharma
Publikováno v:
Biomarkers and Genomic Medicine. 6(3):89-98
The Charnoly body (CB) is a pleomorphic, electron-dense, multilamellar, preapoptotic, mitochondrial biomarker of cell injury. Nutritional stress and environmental toxins induce CB formation in highly vulnerable developing neurons because of compromis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7d9e74d9aa36bb8181bcc1b83b8aea
Publikováno v:
Neurochemical Research. 39:225-232
Several lines of evidence suggest that the mechanism underlying drug-induced neuronal apoptosis is initiated by the increased production of reactive oxygen species (ROS). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a neurotoxin, has been sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de753b1144daa040a0cb0383638a1ca
https://doi.org/10.1007/s11064-013-1208-8
https://doi.org/10.1007/s11064-013-1208-8
Publikováno v:
Journal of Pineal Research. 49:382-389
Methamphetamine (METH) is a common drug of abuse that induces toxicity in the central nervous system and is connected to neurological disorders such as Parkinson's disease. METH neurotoxicity is induced by reactive oxygen species (ROS) production and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ecd6a42036598c5c99ec0de3fecd142
https://doi.org/10.1111/j.1600-079x.2010.00805.x
https://doi.org/10.1111/j.1600-079x.2010.00805.x
Publikováno v:
Neuroscience Letters. 461:258-261
Secretion of melatonin by the mammalian pineal gland is primarily regulated by the release of norepinephrine (NE) from sympathetic nerve terminals that originate from the superior cervical ganglia. Peptidergic nerves that originate in the perikarya l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7e88c299504436bb07f84d25a6ed43
https://doi.org/10.1016/j.neulet.2009.06.040
https://doi.org/10.1016/j.neulet.2009.06.040
Publikováno v:
Neuroscience Letters. 439:125-128
Alpha-synuclein (alpha-syn) is implicated in the pathogenesis of Parkinson's disease (PD). Mutations in alpha-syn gene or alpha-syn locus (SNCA) triplication are associated with mitochondrial abnormalities and early onset of familial PD. The goals of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1f93a2240d8e4b91cd510aad44cd94
https://doi.org/10.1016/j.neulet.2008.05.005
https://doi.org/10.1016/j.neulet.2008.05.005
Publikováno v:
Neuroscience Letters. 419:59-63
Methamphetamine (METH) is a well-known drug of abuse and neurotoxin that may cause temporary or permanent disturbances in the dopaminergic systems of the brain, predisposing individuals to Parkinsonism. Previously, we have shown that METH causes dopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3be1ba847b2e51dc400ddd20dd90c87
https://doi.org/10.1016/j.neulet.2007.03.073
https://doi.org/10.1016/j.neulet.2007.03.073
Publikováno v:
Neurochemical Research. 32:443-450
Salsolinol, an endogenous neurotoxin, is known to be involved in the pathogenesis of Parkinson's disease (PD). In the present study, we have investigated the effects of salsolinol on the activation of two different signaling pathways that involve c-J
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981805259ff599201739abd32b0541c4
https://doi.org/10.1007/s11064-006-9246-0
https://doi.org/10.1007/s11064-006-9246-0
Autor:
Manuchair Ebadi, Sushil Sharma
Publikováno v:
Experimental Biology and Medicine. 231:1576-1583
We have examined potent peroxynitrite ion (ONOO-) generator 3-morpholinosydnonimine (SIN-1)–induced neurotoxicity in control wild-type (controlwt) mice, metallothionein double knockout (MTdko) mice, metallothionein-transgenic (MTtrans) mice, and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d5b6c3145c3a2ec2f36c65a5e59b1b
https://doi.org/10.1177/153537020623100919
https://doi.org/10.1177/153537020623100919
Publikováno v:
Brain Research. 1099:141-149
Salsolinol, an endogenous neurotoxin, may be involved in the pathogenesis of Parkinson's disease. In this study, we sought to determine whether salsolinol-induced cytotoxicity in SH-SY5Y human neuroblastoma cells, a cloned cell line which expresses d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d447328adb0d8b129b51e729a6af4d3
https://doi.org/10.1016/j.brainres.2006.04.104
https://doi.org/10.1016/j.brainres.2006.04.104