Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Manu P. Kumar"'
Autor:
Paige N. Vega, Avlant Nilsson, Manu P. Kumar, Hiroaki Niitsu, Alan J. Simmons, James Ro, Jiawei Wang, Zhengyi Chen, Brian A. Joughin, Wei Li, Eliot T. McKinley, Qi Liu, Joseph T. Roland, M. Kay Washington, Robert J. Coffey, Douglas A. Lauffenburger, Ken S. Lau
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The tumor microenvironment plays a key role in the pathogenesis of colorectal tumors and contains various cell types including epithelial, immune, and mesenchymal cells. Characterization of the interactions between these cell types is necessary for r
Externí odkaz:
https://doaj.org/article/6217fa8676db45dfb3ac2e1f123faa26
Autor:
Christian H. Holland, Jovan Tanevski, Javier Perales-Patón, Jan Gleixner, Manu P. Kumar, Elisabetta Mereu, Brian A. Joughin, Oliver Stegle, Douglas A. Lauffenburger, Holger Heyn, Bence Szalai, Julio Saez-Rodriguez
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-19 (2020)
Abstract Background Many functional analysis tools have been developed to extract functional and mechanistic insight from bulk transcriptome data. With the advent of single-cell RNA sequencing (scRNA-seq), it is in principle possible to do such an an
Externí odkaz:
https://doaj.org/article/d1849aa64c034f01813aa554e25e81e8
Autor:
Manu P. Kumar, Jinyan Du, Georgia Lagoudas, Yang Jiao, Andrew Sawyer, Daryl C. Drummond, Douglas A. Lauffenburger, Andreas Raue
Publikováno v:
Cell Reports, Vol 25, Iss 6, Pp 1458-1468.e4 (2018)
Summary: Tumor ecosystems are composed of multiple cell types that communicate by ligand-receptor interactions. Targeting ligand-receptor interactions (for instance, with immune checkpoint inhibitors) can provide significant benefits for patients. Ho
Externí odkaz:
https://doaj.org/article/04de4b9d7c674dbbadc580b6327c748a
Akademický článek
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Akademický článek
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Autor:
Douglas A. Lauffenburger, Christian H. Holland, Manu P. Kumar, Javier Perales-Patón, Holger Heyn, Elisabetta Mereu, Brian A. Joughin, Bence Szalai, Julio Saez-Rodriguez, Oliver Stegle, Jan Gleixner, Jovan Tanevski
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-19 (2020)
Genome Biology
Genome Biology
BACKGROUND: Many functional analysis tools have been developed to extract functional and mechanistic insight from bulk transcriptome data. With the advent of single-cell RNA sequencing (scRNA-seq), it is in principle possible to do such an analysis f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ec8ecf0e67a4810cffadb355e6cd64
https://doi.org/10.1186/s13059-020-1949-z
https://doi.org/10.1186/s13059-020-1949-z
Autor:
Cecil Gregg, Alan J. Simmons, Keith T. Wilson, Paige N. Vega, Evan L. Chiswick, Elizabeth A. Scoville, Manu P. Kumar, Lori A. Coburn, Alina Starchenko, Douglas K. Brubaker, Austin N. Southard-Smith, Douglas A. Lauffenburger, Ken S. Lau
Publikováno v:
PMC
Sci Signal
Sci Signal
© 2020 American Association for the Advancement of Science. All rights reserved. Anti-tumor necrosis factor (anti-TNF) therapy resistance is a major clinical challenge in inflammatory bowel disease (IBD), due, in part, to insufficient understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e18cbc0c2e15e9fc33e1fd012322e10
https://hdl.handle.net/1721.1/136133
https://hdl.handle.net/1721.1/136133
Akademický článek
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Autor:
Douglas A. Lauffenburger, Forest M. White, Linda G. Griffith, Kasper Renggli, Manu P. Kumar, Daniel A. Rothenberg, Linda Stockdale, Elizabeth A. Gordon, Jorge Valdez, Alex J. Wang, Christi D. Cook, Alexander Brown, Caroline C. Ahrens
Publikováno v:
Elsevier
Methods to parse paracrine epithelial-stromal communication networks are a vital need in drug development, as disruption of these networks underlies diseases ranging from cancer to endometriosis. Here, we describe a modular, synthetic, and dissolvabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbfe4b06e37b8958cd21c2a404a9d76
https://doi.org/10.1016/j.biomaterials.2017.03.030
https://doi.org/10.1016/j.biomaterials.2017.03.030
Autor:
Elizabeth A. Scoville, Douglas A. Lauffenburger, Manu P. Kumar, Ken S. Lau, Douglas K. Brubaker, Lori A. Coburn, Alan J. Simmons, Austin N. Southard-Smith, Keith T. Wilson, Paige N. Vega
Anti-TNF therapy resistance is a major clinical challenge in Crohn’s Disease (CD), partly due to insufficient understanding of disease-site, protein-level mechanisms of CD and anti-TNF treatment resistance. Although some proteomics data from CD mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ccc99a31fee52c1fad1549e15e2826