Výsledky vyhledávání - "Mantyh, Patrick"

Akademický článek

Immunohistochemical localization of nerve growth factor, tropomyosin receptor kinase A, and p75 in the bone and articular cartilage of the mouse femur

Autor: Chartier, Stephane R, Mitchell, Stefanie AT, Majuta, Lisa A, Mantyh, Patrick W

Sequestration of nerve growth factor (NGF) significantly attenuates skeletal pain in both animals and humans. However, relatively little is known about the specific cell types that express NGF or its cognate receptors tropomyosin receptor kinase A (T

Externí odkaz: http://hdl.handle.net/10150/626456
http://arizona.openrepository.com/arizona/handle/10150/626456

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Akademický článek

Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent

Autor: Vanderah, Todd, Hanlon, Katherine, Lozano-Ondoua, Alysia, Umaretiya, Puja, Symons-Ligouri, Ashley, Chandramouli, Anupama, Moy, Jamie, Kwass, William, Mantyh, Patrick, Nelson, Mark

Introduction: Cannabinoid compounds, both nonspecific as well as agonists selective for either cannabinoid receptor 1 (CB1) or cannabinoid receptor 2 (CB2), have been shown to modulate the tumor microenvironment by inducing apoptosis in tumor cells i

Externí odkaz: http://hdl.handle.net/10150/614744
http://arizona.openrepository.com/arizona/handle/10150/614744

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Akademický článek

Sensory and sympathetic nerve fibers undergo sprouting and neuroma formation in the painful arthritic joint of geriatric mice

Autor: Jimenez-Andrade, Juan, Mantyh, Patrick

INTRODUCTION:Although the prevalence of arthritis dramatically increases with age, the great majority of preclinical studies concerning the mechanisms that drive arthritic joint pain have been performed in young animals. One mechanism hypothesized to

Externí odkaz: http://hdl.handle.net/10150/610392
http://arizona.openrepository.com/arizona/handle/10150/610392

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Akademický článek

Pathophysiology and medical treatment of pain in fibrous dysplasia of bone

Autor: Chapurlat, Roland, Gensburger, Deborah, Jimenez-Andrade, Juan, Ghilardi, Joseph, Kelly, Marilyn, Mantyh, Patrick

One of the most common complications of fibrous dysplasia of bone (FD) is bone pain. Usual pain killers are often of inadequate efficacy to control this bone pain. The mechanism of bone pain in FD remains uncertain, but by analogy with bone tumors on

Externí odkaz: http://hdl.handle.net/10150/610228
http://arizona.openrepository.com/arizona/handle/10150/610228

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Akademický článek

Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain

Autor: Ghilardi, Joseph, Freeman, Katie, Jimenez-Andrade, Juan, Mantyh, William, Bloom, Aaron, Kuskowski, Michael, Mantyh, Patrick

Pain often accompanies cancer and most current therapies for treating cancer pain have significant unwanted side effects. Targeting nerve growth factor (NGF) or its cognate receptor tropomyosin receptor kinase A (TrkA) has become an attractive target

Externí odkaz: http://hdl.handle.net/10150/610212
http://arizona.openrepository.com/arizona/handle/10150/610212

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Akademický článek

Vascularization of the dorsal root ganglia and peripheral nerve of the mouse: Implications for chemical-induced peripheral sensory neuropathies

Autor: Jimenez-Andrade, Juan, Herrera, Monica, Ghilardi, Joseph, Vardanyan, Marina, Melemedjian, Ohannes, Mantyh, Patrick

Although a variety of industrial chemicals, as well as several chemotherapeutic agents used to treat cancer or HIV, preferentially induce a peripheral sensory neuropathy what remains unclear is why these agents induce a sensory vs. a motor or mixed n

Externí odkaz: http://hdl.handle.net/10150/610211
http://arizona.openrepository.com/arizona/handle/10150/610211

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