Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Mantu Bhaumik"'
Autor:
Celine J. Granier, Wei Wang, Tiffany Tsang, Ruth Steward, Hatem E. Sabaawy, Mantu Bhaumik, Arnold B. Rabson
Publikováno v:
Biology Open, Vol 3, Iss 9, Pp 821-831 (2014)
PDCD2 (programmed cell death domain 2) is a highly conserved, zinc finger MYND domain-containing protein essential for normal development in the fly, zebrafish and mouse. The molecular functions and cellular activities of PDCD2 remain unclear. In ord
Externí odkaz:
https://doaj.org/article/0d69793f6c9a4787926bc52e81e220ba
Autor:
Huimei Lu, Yi-Yuan Huang, Sonam Mehrotra, Roberto Droz-Rosario, Jingmei Liu, Mantu Bhaumik, Eileen White, Zhiyuan Shen
Publikováno v:
PLoS Genetics, Vol 7, Iss 9, p e1002291 (2011)
BCCIP is a BRCA2- and CDKN1A(p21)-interacting protein that has been implicated in the maintenance of genomic integrity. To understand the in vivo functions of BCCIP, we generated a conditional BCCIP knockdown transgenic mouse model using Cre-LoxP med
Externí odkaz:
https://doaj.org/article/9da5240063e44af882029b3d79199495
Autor:
Amanda J Beck, Joseph M Vitale, Qingshi Zhao, Joel S Schneider, Corey Chang, Aneela Altaf, Jennifer Michaels, Mantu Bhaumik, Robert Grange, Diego Fraidenraich
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20065 (2011)
Duchenne muscular dystrophy (DMD) is an incurable degenerative muscle disorder. We injected WT mouse induced pluripotent stem cells (iPSCs) into mdx and mdx∶utrophin mutant blastocysts, which are predisposed to develop DMD with an increasing degree
Externí odkaz:
https://doaj.org/article/28d3b4b091ad403a8544e8f69fbd187d
Autor:
Elizabeth Stillwell, Joseph Vitale, Qingshi Zhao, Amanda Beck, Joel Schneider, Farah Khadim, Genie Elson, Aneela Altaf, Ghassan Yehia, Jia-hui Dong, Jing Liu, Willie Mark, Mantu Bhaumik, Robert Grange, Diego Fraidenraich
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4759 (2009)
Duchenne muscular dystrophy (DMD) is an incurable neuromuscular degenerative disease, caused by a mutation in the dystrophin gene. Mdx mice recapitulate DMD features. Here we show that injection of wild-type (WT) embryonic stem cells (ESCs) into mdx
Externí odkaz:
https://doaj.org/article/4c9611a44dd7423eac61150c61fd0b3e
Autor:
Caiyong Ye, Zhiyuan Shen, Jingmei Liu, Chen Liu, Huimei Lu, Mantu Bhaumik, Bing Xia, Xing Feng
Publikováno v:
Am J Pathol
Hepatocellular carcinoma (HCC) is the most common form of liver tumors. Although HCC is associated with chronic viral infections, alcoholic cirrhosis, and nonalcoholic fatty liver disease, genetic factors that contribute to the HCC risk remain unknow
Autor:
Christine R. Zheng, Luke W. Koblan, Jonathan M. Levy, Olga Shubina-Oleinik, Wei-Hsi Yeh, Christine D. Wilson, Gregory A. Newby, Jeffrey R. Holt, Benjamin W. Thuronyi, Mantu Bhaumik, David R. Liu
Publikováno v:
Nature biotechnology
Base editors use DNA-modifying enzymes targeted with a catalytically impaired CRISPR protein to precisely install point mutations. Here, we develop phage-assisted continuous evolution of base editors (BE-PACE) to improve their editing efficiency and
Autor:
Srilatha Simhadri, Samuel F. Bunting, Shoreh Miller, Shridar Ganesan, Yanying Huo, Bing Xia, Shaun E. Peterson, Mantu Bhaumik, Thomas Ludwig, Dharm S Patel, Maria Jasin, Christian Bowman-Colin, Hong Cai
Publikováno v:
Journal of Biological Chemistry. 289:24617-24629
PALB2 links BRCA1 and BRCA2 in homologous recombinational repair of DNA double strand breaks (DSBs). Mono-allelic mutations in PALB2 increase the risk of breast, pancreatic, and other cancers, and biallelic mutations cause Fanconi anemia (FA). Like B
Autor:
Luke W. Koblan, Christine D. Wilson, Benjamin W. Thuronyi, Mantu Bhaumik, David R. Liu, Gregory A. Newby, Olga Shubina-Oleinik, Jeffrey R. Holt, Jonathan M. Levy, Wei-Hsi Yeh, Christine R. Zheng
Publikováno v:
Nature Biotechnology. 37:1091-1091
Autor:
Arnold B. Rabson, Mantu Bhaumik, Jer-Ming Chang, Peter Mundel, Sevgi Gurkan, Allison Cabinian, Victoria Lopez
Publikováno v:
The Journal of Pathology. 231:248-256
The mechanisms by which inflammation or autoimmunity causes proteinuric kidney disease remain elusive. Yet proteinuria is a hallmark and a prognostic indicator of kidney disease, and also an independent risk factor for cardiovascular morbidity and mo
Autor:
Celine J. Granier, Mantu Bhaumik, Yuan Xiang Tao, Ghassan Yehia, J. Patrick Gonzalez, Natalia Shirokova, Kevin C. Lahey, Joel S. Schneider, Viktoriia Kyrychenko, Sergii Kyrychenko, Qingshi Zhao, Eric Himelman, Diego Fraidenraich
Publikováno v:
Stem cells (Dayton, Ohio). 35(3)
Duchenne muscular dystrophy (DMD) is characterized by the loss of the protein dystrophin, leading to muscle fragility, progressive weakening, and susceptibility to mechanical stress. Although dystrophin-negative mdx mouse models have classically been