A CAR enhancer increases the activity and persistence of CAR T cells.

Autor: Rakhshandehroo T; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Mantri SR; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Moravej H; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Louis BBV; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Salehi Farid A; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Munaretto L; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Regan K; Department of Biomedical Engineering, Boston University, Boston, MA, USA., Khan RMM; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Wolff A; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Farkash Z; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Cong M; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Kuhnast A; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Nili A; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Lee UJ; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Allen HH; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Berland L; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Simkova E; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Uslu SC; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Tavakolpour S; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Rowley JE; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biomedical Engineering, Boston University, Boston, MA, USA., Codet E; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Shahbazian H; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Baral J; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Pyrdol J; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Jacobson CA; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Nadeem O; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Nia HT; Department of Biomedical Engineering, Boston University, Boston, MA, USA., Wucherpfennig KW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA., Rashidian M; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. Mohammad_rashidian@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. Mohammad_rashidian@dfci.harvard.edu.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. Mohammad_rashidian@dfci.harvard.edu.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Mohammad_rashidian@dfci.harvard.edu.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2024 Jul 30. Date of Electronic Publication: 2024 Jul 30.

In situ tumour arrays reveal early environmental control of cancer immunity.

Autor: Ortiz-Muñoz G; Genentech, South San Francisco, CA, USA., Brown M; Genentech, South San Francisco, CA, USA., Carbone CB; Genentech, South San Francisco, CA, USA., Pechuan-Jorge X; Genentech, South San Francisco, CA, USA., Rouilly V; Genentech, South San Francisco, CA, USA., Lindberg H; Genentech, South San Francisco, CA, USA., Ritter AT; Genentech, South San Francisco, CA, USA., Raghupathi G; Department of Computer Science, Stanford University, Stanford, CA, USA., Sun Q; Genentech, South San Francisco, CA, USA., Nicotra T; Genentech, South San Francisco, CA, USA., Mantri SR; Genentech, South San Francisco, CA, USA., Yang A; Genentech, South San Francisco, CA, USA., Doerr J; Genentech, South San Francisco, CA, USA., Nagarkar D; Genentech, South San Francisco, CA, USA., Darmanis S; Genentech, South San Francisco, CA, USA., Haley B; Genentech, South San Francisco, CA, USA., Mariathasan S; Genentech, South San Francisco, CA, USA., Wang Y; Genentech, South San Francisco, CA, USA., Gomez-Roca C; IUCT, Institut Universitaire du Cancer de Toulouse, Toulouse, France., de Andrea CE; Department of Pathology, Clínica Universidad de Navarra, Pamplona, Spain., Spigel D; Sarah Cannon Research Institute, Nashville, TN, USA., Wu T; Genentech, South San Francisco, CA, USA., Delamarre L; Genentech, South San Francisco, CA, USA., Schöneberg J; Department of Pharmacology, UCSD, San Diego, CA, USA.; Department of Chemistry & Biochemistry, UCSD, San Diego, CA, USA., Modrusan Z; Genentech, South San Francisco, CA, USA., Price R; Genentech, South San Francisco, CA, USA., Turley SJ; Genentech, South San Francisco, CA, USA., Mellman I; Genentech, South San Francisco, CA, USA., Moussion C; Genentech, South San Francisco, CA, USA. moussion.christine@gene.com.

Publikováno v: Nature [Nature] 2023 Jun; Vol. 618 (7966), pp. 827-833. Date of Electronic Publication: 2023 May 31.