Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Manthinda Hettiarachchi"'
1
Long-term high-fat feeding leads to severe insulin resistance but not diabetes in Wistar rats
Autor: Manthinda Hettiarachchi, Donald J. Chisholm, Simon M Chalkley, Edward W. Kraegen
Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 282:E1231-E1238
Although lipid excess can impair β-cell function in vitro, short-term high-fat feeding in normal rats produces insulin resistance but not hyperglycemia. This study examines the effect of long-term (10-mo) high polyunsaturated fat feeding on glucose
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b461672b5ed0f737400fc63f9d9517d
https://doi.org/10.1152/ajpendo.00173.2001
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2
Human growth hormone fragment (hGH44–191) produces insulin resistance and hyperinsulinemia but is less potent than the 22 kDa hGH in the rat
Autor: Edward W. Kraegen, Manthinda Hettiarachchi, Ken K. Y. Ho, Allan Watkinson, Kin-Chuen Leung, Yagya N. Sinha
Publikováno v: Endocrine. 6:47-52
A 17 kDa fragment of human growth hormone (22 kDa hGH), identified as hGH44-191, has lower binding affinity for growth hormone receptors (GHRs), but has been reported to be more potent in producing glucose intolerance in yellow obese mice. Out aim wa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7c4e5192db5e6689f1040e68c7168bd
https://doi.org/10.1007/bf02738801
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3
Growth Hormone–Induced Insulin Resistance and Its Relationship to Lipid Availability in the Rat
Autor: Arthur B. Jenkins, Vicki Theos, Edward W. Kraegen, Manthinda Hettiarachchi, Allan Watkinson, Ken K. Y. Ho
Publikováno v: Diabetes. 45:415-421
The role of increased lipid availability in the generation of insulin resistance by growth hormone has not been established. We investigated this in rats infused with saline (controls) or human growth hormone (hGH) (500 μg · kg− · 24 h−1) for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425f36461990436fa3228e67efa86914
https://doi.org/10.2337/diab.45.4.415
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4
Vasoconstrictor-mediated release of lactate from the perfused rat hindlimb
Autor: Stephen M. Richards, Stephen Rattigan, K. M. Parsons, Kim A. Dora, Michael G. Clark, Manthinda Hettiarachchi, Eric Q. Colquhoun
Publikováno v: Journal of Applied Physiology. 73:2544-2551
The effects of different vasomodulators on lactate release by the constant-flow-perfused rat hindlimb were examined and compared with that by perfused mesenteric artery, incubated preparations of aortas, soleus and epitrochlearis muscles, and perifus
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c71e4e770fe6ea6ee1e48c1a046a5b
https://doi.org/10.1152/jappl.1992.73.6.2544
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5
Flow-induced oxygen uptake by the perfused rat hindlimb is inhibited by vasodilators and augmented by norepinephrine: a possible role for the microvasculature in hindlimb thermogenesis
Autor: Michael G. Clark, Ji-Ming Ye, Eric Q. Colquhoun, Manthinda Hettiarachchi
Publikováno v: Canadian Journal of Physiology and Pharmacology. 68:119-125
Oxygen uptake in the perfused rat hindlimb was studied at 25 °C using an artificial perfusate, and the effects of perfusate flow rate, norepinephrine, and vasodilators were compared. Hindlimb oxygen uptake and perfusion pressure each increased as th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08f5a49fe483e6037f1c049c49baba9
https://doi.org/10.1139/y90-018
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6
A close association between vasoconstrictor-mediated uracil and lactate release by the perfused rat hindlimb
Autor: Kim A. Dora, Michael G. Clark, Stephen Rattigan, Manthinda Hettiarachchi, Stephen M. Richards, Eric Q. Colquhoun
Publikováno v: General pharmacology. 23(1)
1. Angiotensin II (5 nM) increased perfusion pressure, O2 uptake and the release of lactate, uracil and uric acid from the perfused rat hindlimb. The release of all three substances was greatest 5 min after commencement of angiotensin II infusion and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1cdae87c2f12d05d4011465a41c7ebc
https://pubmed.ncbi.nlm.nih.gov/1592227
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7
The apparent absence of serotonin-mediated vascular thermogenesis in perfused rat hindlimb may result from vascular shunting
Autor: Michael G. Clark, Manthinda Hettiarachchi, Kim A. Dora, Stephen Rattigan, Eric Q. Colquhoun
Publikováno v: Life sciences. 48(16)
Vasoconstriction by norepinephrine, angiotensin II and vasopressin in the constant-flow perfused rat hindlimb is associated with increased oxygen uptake and has given rise to the concept of vascular thermogenesis. In the present study serotonin (5-hy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da65950190adcae6aaad3562d9371c82
https://pubmed.ncbi.nlm.nih.gov/2016989
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9
Inhibition by vasodilators of noradrenaline and vasoconstrictor-mediated, but not skeletal muscle contraction-induced oxygen uptake in the perfused rat hindlimb; implications for non-shivering thermogenesis in muscle tissue
Autor: Ji-Ming Ye, Michael G. Clark, Manthinda Hettiarachchi, Stephen Rattigan, Eric Q. Colquhoun
Publikováno v: General pharmacology. 21(1)
1. 1. The effect of noradrenaline as well as of vasopressin and angiotensin II to increase oxygen uptake and perfusion pressure by the isolated perfused rat hindlimb were completely inhibited by the vasodilators, nitroprusside (0.5 mM), nifedipine (2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99887c427af98da563e1530cdff2e374
https://pubmed.ncbi.nlm.nih.gov/2298385
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