Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mansuo Hayashi"'
Autor:
Simon Dujardin, Analiese Fernandes, Riley Bannon, Caitlin Commins, Mark De Los Santos, Tarun V. Kamath, Mansuo Hayashi, Bradley T. Hyman
Publikováno v:
Brain Communications. 4
Progressive cognitive decline in Alzheimer’s disease correlates closely with the spread of tau protein aggregation across neural networks of the cortical mantle. We tested the hypothesis that heritable factors may influence the rate of propagation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf746aa4df379e97330f042332f8853
https://doi.org/10.1093/braincomms/fcac048
https://doi.org/10.1093/braincomms/fcac048
Autor:
Dujardin, Simon, Fernandes, Analiese, Bannon, Riley, Commins, Caitlin, De Los Santos, Mark, Kamath, Tarun V., Mansuo Hayashi, Hyman, Bradley T.
Publikováno v:
Brain Communications; 2022, Vol. 4 Issue 2, p1-8, 8p
Autor:
Matthew G. Stanton, Sanjeev Munshi, Ian W. Davies, Kaleen Konrad Childers, Michael Hutton, Lee Warren, Mansuo Hayashi, Anna A. Zabierek, Alan B. Northrup, Alexander A. Szewczak, Hugh Nuthall, Andrew M. Haidle, Ben Munoz, Dapeng Chen, Hua-Poo Su, Yongquan Hou, Jason D. Katz, Andreas Harsch, Michael D. Altman, James P. Jewell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:114-120
The initial structure activity relationships around an isoindoline uHTS hit will be described. Information gleaned from ligand co-crystal structures allowed for rapid refinements in both MARK potency and kinase selectivity. These efforts allowed for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20493003f7f8446544809a814383d0f7
https://doi.org/10.1016/j.bmcl.2016.08.068
https://doi.org/10.1016/j.bmcl.2016.08.068
Autor:
Andrew M. Haidle, Alan B. Northrup, Alexander A. Szewczak, Lee Warren, Jason D. Katz, James P. Jewell, Mansuo Hayashi, Hugh Nuthall, Andreas Harsch, Michael D. Altman, Ian W. Davies, Dapeng Chen, Kaleen Konrad Childers, Michael Hutton, Anna A. Zabierek, Matthew G. Stanton, Yongquan Hou, Ben Munoz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:109-113
Attempts to optimize pharmacokinetic properties in a promising series of pyrrolopyrimidinone MARK inhibitors for the treatment of Alzheimer's disease are described. A focus on physical properties and ligand efficiency while prosecuting this series af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc8536570d3d5135b8796086271560b
https://doi.org/10.1016/j.bmcl.2016.08.066
https://doi.org/10.1016/j.bmcl.2016.08.066
Autor:
Lee Warren, Suzanne C. Edavettal, Jacob Marcus, Matthew G. Stanton, Hugh Nuthall, David L. Sloman, Tammy Dellovade, Alexander A. Szewczak, Deborah Walker, Sanjeev Munshi, Andrea C. Mislak, Michael Hutton, Michael D. Altman, Zhenhua Wu, Mansuo Hayashi, Dapeng Chen, Hua-Poo Su, Njamkou Noucti
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(17)
Inhibition of microtubule affinity regulating kinase (MARK) represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer’s disease. This manuscript outlines efforts to optimize a pyrazolopyrimidine series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7ecae5b310e12910bfeea4ba9e5416
https://pubmed.ncbi.nlm.nih.gov/27491711
https://pubmed.ncbi.nlm.nih.gov/27491711
Autor:
Sébastien S. Hébert, Neil R. Smalheiser, Gail A. M. Breen, Peter T. Nelson, Virgil Muresan, Joel R. Neilson, Samuil Umansky, Ben Albensi, Guilian Xu, Anil G. Cashikar, Peter H. Frederikse, Rodney Perry, Mansuo Hayashi, Lisa Stanek, June Kinoshita, Xiyun Chai, Laura Turner, Trinna L. Cuellar, Kenneth S. Kosik, Matthew Townsend, Raymond Chuen-Chung Chang, Lisa Mizumoto, Bryan Maloney, Justin M. Long, Wang-Xia Wang
Publikováno v:
Journal of Alzheimer's Disease. 16:441-444
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48556b59668a05da1212e17a8a7fac28
https://doi.org/10.3233/jad-2009-1007
https://doi.org/10.3233/jad-2009-1007
Autor:
Mansuo Hayashi
Publikováno v:
Alzheimer's & Dementia. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3b0c4122c0145b31dcbf6ee1c1c3b42
https://doi.org/10.1016/j.jalz.2015.08.016
https://doi.org/10.1016/j.jalz.2015.08.016
Publikováno v:
Alzheimer's & Dementia. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fba2da63433d620e6f50b8a56c368f15
https://doi.org/10.1016/j.jalz.2013.05.1760
https://doi.org/10.1016/j.jalz.2013.05.1760
Autor:
Hugh Nuthall, Shang-Shuan Yu, Ron Hendrickson, An Chi, Cloud P. Paweletz, Alan B. Northrup, Mansuo Hayashi
Publikováno v:
Alzheimer's & Dementia. 6
decrease in intracellular vitamin E was associated with the deterioration in cognitive performance. The correlation between oxidative changes and mitochondral dysfunction will be established. Conclusions: These results suggest that accumulation of ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e4c1af8179a99ead14043db826cb77c
https://doi.org/10.1016/j.jalz.2010.05.1680
https://doi.org/10.1016/j.jalz.2010.05.1680
Autor:
Mansuo Hayashi, Jean-Cosme Dodart, Hugh Nuthall, Ilonka Guenther, Alexandre Coimbra, Rose Ann Blenman, Michael Hutton, Mark Shearman
Publikováno v:
Alzheimer's & Dementia. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08b4247317d03820c33f77733b4c7551
https://doi.org/10.1016/j.jalz.2008.05.1095
https://doi.org/10.1016/j.jalz.2008.05.1095