Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mansoora Khaliq"'
Autor:
Michael Callahan, Anthony M Treston, Grace Lin, Marla Smith, Brian Kaufman, Mansoora Khaliq, Lisa Evans DeWald, Kevin Spurgers, Kelly L Warfield, Preeya Lowe, Matthew Duchars, Aruna Sampath, Urban Ramstedt
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010636 (2022)
BackgroundUV-4 (N-(9'-methoxynonyl)-1-deoxynojirimycin, also called MON-DNJ) is an iminosugar small-molecule oral drug candidate with in vitro antiviral activity against diverse viruses including dengue, influenza, and filoviruses and demonstrated in
Externí odkaz:
https://doaj.org/article/1b9a38644e1447e182ac97752d59a1a1
Autor:
Kelly L. Warfield, Dale L. Barnard, Sven G. Enterlein, Donald F. Smee, Mansoora Khaliq, Aruna Sampath, Michael V. Callahan, Urban Ramstedt, Craig W. Day
Publikováno v:
Viruses, Vol 8, Iss 3, p 71 (2016)
Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection aga
Externí odkaz:
https://doaj.org/article/aed3cb696ffc407f90fd4a3af2491ffb
Autor:
Jeffry, Shearer, Gary, Wolfe, Mansoora, Khaliq, Brian, Kaufman, Aruna, Sampath, Kelly L, Warfield, Urban, Ramstedt, Anthony, Treston
Publikováno v:
Reproductive Toxicology. 114:9-21
UV-4 (N-(9-methoxynonyl)-1-deoxynojirimycin) is a host-targeted antiviral agent, which targets mammalian proteins (endoplasmic reticulum glucosidases) rather than virally encoded proteins. This mechanism confers both broad-spectrum activity and low p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbce7b4440487794c9728257110cb2de
https://doi.org/10.1016/j.reprotox.2022.09.007
https://doi.org/10.1016/j.reprotox.2022.09.007
Autor:
Michael Callahan, Anthony M. Treston, Grace Lin, Marla Smith, Brian Kaufman, Mansoora Khaliq, Lisa Evans DeWald, Kevin Spurgers, Kelly L. Warfield, Preeya Lowe, Matthew Duchars, Aruna Sampath, Urban Ramstedt
Publikováno v:
PLoS neglected tropical diseases. 16(8)
Background UV-4 (N-(9’-methoxynonyl)-1-deoxynojirimycin, also called MON-DNJ) is an iminosugar small-molecule oral drug candidate with in vitro antiviral activity against diverse viruses including dengue, influenza, and filoviruses and demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0873e9b2bf0101cdb41da839ce6559f0
https://pubmed.ncbi.nlm.nih.gov/35939501
https://pubmed.ncbi.nlm.nih.gov/35939501
Publikováno v:
Antiviral Research. 80:11-22
With the emergence and rapid spread of West Nile virus in the United States since 1999, and the 50-100 million infections per year caused by dengue virus globally, the threat of flaviviruses as re-emerging human pathogens has become a reality. To sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926db6ff780dd0dcb912de6f81afa991
https://doi.org/10.1016/j.antiviral.2008.05.004
https://doi.org/10.1016/j.antiviral.2008.05.004
Autor:
Michael V. Callahan, Kelly L. Warfield, Dale L. Barnard, Donald F. Smee, Craig W. Day, Mansoora Khaliq, Sven Enterlein, Aruna Sampath, Urban Ramstedt
Publikováno v:
Viruses
Viruses, Vol 8, Iss 3, p 71 (2016)
Viruses, Vol 8, Iss 3, p 71 (2016)
Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d8708e4ee21d313d7c1dbbaec3f451
https://doi.org/10.3390/v8030071
https://doi.org/10.3390/v8030071
Autor:
Abdelrahman S. Mayhoub, Ze Li, Carolyn Botting, Richard J. Kuhn, Mark Cushman, Mansoora Khaliq
Flaviviruses are one of the most clinically important pathogens and their infection rates are increasing steadily. The phenylthiazole ring system has provided a template for the design and synthesis of antiviral agents that inhibit the flaviviruses b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1674b26aaa6259089947f00bbce86bb2
https://europepmc.org/articles/PMC3119515/
https://europepmc.org/articles/PMC3119515/
Publikováno v:
Journal of medicinal chemistry. 54(6)
A series of third-generation analogues of methyl 4-(dibromomethyl)-2-(4-chlorophenyl)thiazole-5-carboxylate (1), which had the most potent antiviral activity among the first- and second-generation compounds, have been synthesized and tested against y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24ed0ce1ec1a38792a3db2e25332f2d
https://pubmed.ncbi.nlm.nih.gov/21355607
https://pubmed.ncbi.nlm.nih.gov/21355607
Autor:
Long Li, Zhigang Zhou, Carol Beth Post, Mansoora Khaliq, Jae-Eun Suk, Richard J. Kuhn, Chinmay G. Patkar
Publikováno v:
ACS chemical biology. 3(12)
Infection by the mosquito-borne dengue virus causes dengue fever and the sometimes fatal dengue hemorrhagic fever. The increasing number of dengue infections per year suggests that the virus is becoming more virulent and its transmission is expanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5d4e6e6f30a43e4d6ada27e8126074
https://pubmed.ncbi.nlm.nih.gov/19053243
https://pubmed.ncbi.nlm.nih.gov/19053243
Publikováno v:
Journal of medicinal chemistry. 51(15)
Flavivirus envelope proteins (E proteins) have been shown to play a pivotal role in virus assembly, morphogenesis, and infection of host cells. Inhibition of flavivirus infection of a host cell by means of a small molecule envelope protein antagonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2451e4d99278aecab0918acba53a7c7
https://pubmed.ncbi.nlm.nih.gov/18610998
https://pubmed.ncbi.nlm.nih.gov/18610998