Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mansoor Chishty"'
Autor:
Eliezer Masliah, Birgit Hutter-Paier, Katharina Strempfl, Miriam Holztrattner, Julia Garnweidner-Raith, Michael S. Unger, Nadine Pillichshammer, Thomas K. Felder, Edward Rockenstein, Johannes Attems, Julia Marschallinger, Iris Leister, Mary Johnson, Barbara Altendorfer, Mansoor Chishty, Ludwig Aigner
Publikováno v:
Neurotherapeutics
Dementia with Lewy bodies (DLB) represents a huge medical need as it accounts for up to 30% of all dementia cases, and there is no cure available. The underyling spectrum of pathology is complex and creates a challenge for targeted molecular therapie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0daddd6006713ff3ebfa46f360ac5c
http://europepmc.org/articles/PMC7609773
http://europepmc.org/articles/PMC7609773
Autor:
David E. Hibbs, Stephen J. Fuller, James O'Brien-Brown, Leanne Stokes, Michael Kassiou, Melissa L. Barron, Kristen K. Skarratt, Danielle J. Vugts, Eryn L. Werry, Mansoor Chishty, Albert D. Windhorst, Shane M. Wilkinson, Jennifer Ong, Bieneke Janssen
Publikováno v:
ACS Chemical Neuroscience, 8(11), 2374-2380. American Chemical Society
Wilkinson, S M, Barron, M L, O'Brien-Brown, J, Janssen, B, Stokes, L, Werry, E L, Chishty, M, Skarratt, K K, Ong, J A, Hibbs, D E, Vugts, D J, Fuller, S, Windhorst, A D & Kassiou, M 2017, ' Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X 7 Receptor Antagonist ', ACS Chemical Neuroscience, vol. 8, no. 11, pp. 2374-2380 . https://doi.org/10.1021/acschemneuro.7b00272
Wilkinson, S M, Barron, M L, O'Brien-Brown, J, Janssen, B, Stokes, L, Werry, E L, Chishty, M, Skarratt, K K, Ong, J A, Hibbs, D E, Vugts, D J, Fuller, S, Windhorst, A D & Kassiou, M 2017, ' Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X 7 Receptor Antagonist ', ACS Chemical Neuroscience, vol. 8, no. 11, pp. 2374-2380 . https://doi.org/10.1021/acschemneuro.7b00272
Adamantanyl benzamide 1 was identified as a potent P2X7R antagonist but failed to progress further due to poor metabolic stability. We describe the synthesis and SAR of a series of bioisosteres of benzamide 1 to explore improvements in the pharmacolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e25e9511494084bb5f07b005c53217
https://doi.org/10.1021/acschemneuro.7b00272
https://doi.org/10.1021/acschemneuro.7b00272
Autor:
Jeroen J.M. Hoozemans, Rostislav V Shevchenko, Ger T. Molenaar, Veerle Baekelandt, Sylvie Chalon, Aurélie Doméné, Guy Bormans, Adriana Maggi, Wissam Beaino, Michael Kassiou, Adriaan A. Lammertsma, Uta Funke, Shane M. Wilkinson, Robert C. Schuit, Alessandro Villa, Esther J.M. Kooijman, Johan van den Hoek, Bieneke Janssen, Anke Van der Perren, Mansoor Chishty, Danielle J. Vugts, Albert D. Windhorst, Dieter Ory
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Janssen, B, Vugts, D J, Wilkinson, S M, Ory, D, Chalon, S, Hoozemans, J J M, Schuit, R C, Beaino, W, Kooijman, E J M, Van Den Hoek, J, Chishty, M, Doméné, A, Van Der Perren, A, Villa, A, Maggi, A, Molenaar, G T, Funke, U, Shevchenko, R V, Baekelandt, V, Bormans, G, Lammertsma, A A, Kassiou, M & Windhorst, A D 2018, ' Identification of the allosteric P2X 7 receptor antagonist [ 11 C]SMW139 as a PET tracer of microglial activation ', Scientific Reports, vol. 8, no. 1, 6580 . https://doi.org/10.1038/s41598-018-24814-0
Scientific Reports, 8(1):6580. Nature Publishing Group
Janssen, B, Vugts, D J, Wilkinson, S M, Ory, D, Chalon, S, Hoozemans, J J M, Schuit, R C, Beaino, W, Kooijman, E J M, Van Den Hoek, J, Chishty, M, Doméné, A, Van Der Perren, A, Villa, A, Maggi, A, Molenaar, G T, Funke, U, Shevchenko, R V, Baekelandt, V, Bormans, G, Lammertsma, A A, Kassiou, M & Windhorst, A D 2018, ' Identification of the allosteric P2X 7 receptor antagonist [ 11 C]SMW139 as a PET tracer of microglial activation ', Scientific Reports, vol. 8, no. 1, 6580 . https://doi.org/10.1038/s41598-018-24814-0
Scientific Reports, 8(1):6580. Nature Publishing Group
The P2X7 receptor plays a significant role in microglial activation, and as a potential drug target, the P2X7 receptor is also an interesting target in positron emission tomography. The current study aimed at the development and evaluation of a poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cc71df25ad681f797af725ffc97a78
https://doi.org/10.1038/s41598-018-24814-0
https://doi.org/10.1038/s41598-018-24814-0
Autor:
Bieneke, Janssen, Danielle J, Vugts, Shane M, Wilkinson, Dieter, Ory, Sylvie, Chalon, Jeroen J M, Hoozemans, Robert C, Schuit, Wissam, Beaino, Esther J M, Kooijman, Johan, van den Hoek, Mansoor, Chishty, Aurélie, Doméné, Anke, Van der Perren, Alessandro, Villa, Adriana, Maggi, Ger T, Molenaar, Uta, Funke, Rostislav V, Shevchenko, Veerle, Baekelandt, Guy, Bormans, Adriaan A, Lammertsma, Michael, Kassiou, Albert D, Windhorst
Publikováno v:
Scientific Reports
The P2X7 receptor plays a significant role in microglial activation, and as a potential drug target, the P2X7 receptor is also an interesting target in positron emission tomography. The current study aimed at the development and evaluation of a poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::21b81817e8cfd68703e5cd406318447c
https://pubmed.ncbi.nlm.nih.gov/29700413
https://pubmed.ncbi.nlm.nih.gov/29700413
Autor:
Shane M, Wilkinson, Melissa L, Barron, James, O'Brien-Brown, Bieneke, Janssen, Leanne, Stokes, Eryn L, Werry, Mansoor, Chishty, Kristen K, Skarratt, Jennifer A, Ong, David E, Hibbs, Danielle J, Vugts, Stephen, Fuller, Albert D, Windhorst, Michael, Kassiou
Publikováno v:
ACS chemical neuroscience. 8(11)
Adamantanyl benzamide 1 was identified as a potent P2X
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f294efe0f0c00e352f5e8add6439ffa
https://pubmed.ncbi.nlm.nih.gov/28841278
https://pubmed.ncbi.nlm.nih.gov/28841278
Publikováno v:
NeuroRX. 2:554-571
Summary: The worldwide market for therapies for CNS disorders is worth more than $50 billion and is set to grow substantially in the years ahead. This is because: 1) the incidence of many CNS disorders (e.g., Alzheimer’s disease, stroke, and Parkin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815049979fc23707a53dc5bcdc992a66
https://doi.org/10.1602/neurorx.2.4.554
https://doi.org/10.1602/neurorx.2.4.554
Publikováno v:
Journal of Drug Targeting. 12:265-272
A number of nucleoside analogues, consisting of antiviral compounds and agents designed as adenosine A1 receptor agonists, were examined for nucleoside transporter affinity using an in vitro model of the blood-brain barrier (BBB), the rat brain endot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e81845013ef9ec6a8005bdf05f5c93f
https://doi.org/10.1080/10611860410001731398
https://doi.org/10.1080/10611860410001731398
Publikováno v:
NeuroReport. 14:1087-1090
Multiple nucleoside transport systems exist in the body yet the subtypes functional at the blood-brain barrier (BBB) have not been fully investigated. We have employed RBE4 immortalised rat brain endothelial cells to functionally identify the carrier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a123ccfeb7b918f032810e614ac36a
https://doi.org/10.1097/00001756-200305230-00036
https://doi.org/10.1097/00001756-200305230-00036
Publikováno v:
Glia. 39:99-104
The blood-brain barrier (BBB) is formed by the presence of tight junction complexes between brain endothelial cells that restrict paracellular permeability. As a consequence, a number of transport proteins are expressed on cerebral endothelial cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a30ae4fdedaf8611e43c202c0e71551
https://doi.org/10.1002/glia.10090
https://doi.org/10.1002/glia.10090
S-adenosylmethionine is substrate for carrier mediated transport at the blood-brain barrier in vitro
Publikováno v:
Brain research. 942(1-2)
S-adenosylmethionine (SAM) is the sole methyl donor in the CNS where it is involved in a multitude of biochemical reactions. Peripherally administered SAM has been shown to increase SAM levels in cerebrospinal fluid and is reported to be effective in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6ae20b1f66e08c68429e196cdaf546
https://pubmed.ncbi.nlm.nih.gov/12031851
https://pubmed.ncbi.nlm.nih.gov/12031851