A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study.

Autor: Swen JJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands., van der Wouden CH; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands., Manson LE; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands., Abdullah-Koolmees H; Division Laboratories, Pharmacy and Biomedical Genetics, Hospital Pharmacy, University Medical Centre Utrecht, Utrecht, Netherlands., Blagec K; Centre for Medical Statistics, Informatics and Intelligent Systems, Institute of Artificial Intelligence, Medical University of Vienna, Vienna, Austria., Blagus T; Pharmacogenetics Laboratory, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Böhringer S; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands; Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, Netherlands., Cambon-Thomsen A; CNRS, Centre for Epidemiology and Research in Population health (CERPOP), Université de Toulouse, Inserm, UPS, Toulouse, France., Cecchin E; Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Cheung KC; Medicines Information Centre, Royal Dutch Pharmacists Association (KNMP), The Hague, Netherlands., Deneer VH; Division Laboratories, Pharmacy and Biomedical Genetics, Hospital Pharmacy, University Medical Centre Utrecht, Utrecht, Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Netherlands., Dupui M; Service de pharmacologie médicale et clinique, CEIP-addictovigilance de Toulouse, faculté de médecine, CHU, Toulouse, France., Ingelman-Sundberg M; Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, Stockholm, Sweden., Jonsson S; Department of Pharmacy, Uppsala University, Uppsala, Sweden., Joefield-Roka C; Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria., Just KS; Institute of Clinical Pharmacology, University Hospital RWTH Aachen, Aachen, Germany., Karlsson MO; Department of Pharmacy, Uppsala University, Uppsala, Sweden., Konta L; Bio.logis Digital Health, Frankfurt am Main, Germany., Koopmann R; Bio.logis Digital Health, Frankfurt am Main, Germany; Diagnosticum Centre for Humangenetics, Frankfurt am Main, Germany., Kriek M; Department of Clinical Genetics, Leiden University Medical Centre, Leiden, Netherlands., Lehr T; Clinical Pharmacy, Saarland University, Saarbrücken, Germany., Mitropoulou C; The Golden Helix Foundation, London, UK; Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, Abu Dhabi, United Arab Emirates., Rial-Sebbag E; Universite de Toulouse III Paul Sabatier, Toulouse, France., Rollinson V; Department of Pharmacology and Therapeutics, Wolfson Centre for Personalised Medicine, The University of Liverpool, Liverpool, UK., Roncato R; Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Samwald M; Centre for Medical Statistics, Informatics and Intelligent Systems, Institute of Artificial Intelligence, Medical University of Vienna, Vienna, Austria., Schaeffeler E; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; iFIT Cluster of Excellence (EXC2180)-Image Guided and Functionally Instructed Tumour Therapies, University of Tuebingen, Tuebingen, Germany., Skokou M; University of Patras School of Health Sciences, Department of Pharmacy, Division of Pharmacology and Biosciences, Laboratory of Pharmacogenomics and Individualised Therapy, Patras, Greece., Schwab M; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; iFIT Cluster of Excellence (EXC2180)-Image Guided and Functionally Instructed Tumour Therapies, University of Tuebingen, Tuebingen, Germany; Department of Clinical Pharmacology, University of Tuebingen, Tuebingen, Germany; Department of Pharmacy and Biochemistry, University of Tuebingen, Tuebingen, Germany., Steinberger D; Bio.logis Digital Health, Frankfurt am Main, Germany; Diagnosticum Centre for Humangenetics, Frankfurt am Main, Germany., Stingl JC; Institute of Clinical Pharmacology, University Hospital RWTH Aachen, Aachen, Germany., Tremmel R; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany., Turner RM; Department of Pharmacology and Therapeutics, Wolfson Centre for Personalised Medicine, The University of Liverpool, Liverpool, UK., van Rhenen MH; Medicines Information Centre, Royal Dutch Pharmacists Association (KNMP), The Hague, Netherlands., Dávila Fajardo CL; Clinical Pharmacy Department, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Biosanitaria Granada, Granada, Spain., Dolžan V; Pharmacogenetics Laboratory, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Patrinos GP; Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, Abu Dhabi, United Arab Emirates; Zayed Centre for Health Sciences, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, Abu Dhabi, United Arab Emirates; University of Patras School of Health Sciences, Department of Pharmacy, Division of Pharmacology and Biosciences, Laboratory of Pharmacogenomics and Individualised Therapy, Patras, Greece; Erasmus University Medical Centre, Faculty of Medicine and Health Sciences, Department of Pathology-Clinical Bioinformatics Unit, Rotterdam, Netherlands., Pirmohamed M; Department of Pharmacology and Therapeutics, Wolfson Centre for Personalised Medicine, The University of Liverpool, Liverpool, UK., Sunder-Plassmann G; Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria., Toffoli G; Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Guchelaar HJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands. Electronic address: h.j.guchelaar@lumc.nl.

Publikováno v: Lancet (London, England) [Lancet] 2023 Feb 04; Vol. 401 (10374), pp. 347-356.