Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Manpreet K. Semwal"'
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The thymus is the primary site of T lymphocyte development, where mutually inductive signaling between lymphoid progenitors and thymic stromal cells directs the progenitors along a well-characterized program of differentiation. Although thymic stroma
Externí odkaz:
https://doaj.org/article/6a29a05d8dcf474591b384cd41bb47b9
Autor:
Sergio Cepeda, Carolina Cantu, Stephanie Orozco, Yangming Xiao, Zoe Brown, Manpreet K. Semwal, Thomas Venables, Mark S. Anderson, Ann V. Griffith
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1276-1287 (2018)
Summary: Although autoimmune disorders are a significant source of morbidity and mortality in older individuals, the mechanisms governing age-associated increases in susceptibility remain incompletely understood. Central T cell tolerance is mediated
Externí odkaz:
https://doaj.org/article/2fc1001756ed417bbfa034df07a3b141
Autor:
Manpreet K. Semwal, Allison K. Hester, Yangming Xiao, Chioma Udeaja, Sergio Cepeda, John S. Verschelde, Nicholas Jones, Sarah A. Wedemeyer, Simon Emtage, Kymberly Wimberly, Ann V. Griffith
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(40)
Thymic stromal cells (TSCs) are critical regulators of T cell tolerance, but their basic biology has remained under-characterized because they are relatively rare and difficult to isolate. Recent work has revealed that constitutive autophagy in TSCs
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
The thymus is the primary site of T lymphocyte development, where mutually inductive signaling between lymphoid progenitors and thymic stromal cells directs the progenitors along a well-characterized program of differentiation. Although thymic stroma
Autor:
Allison K. Hester, Manpreet K. Semwal, Sergio Cepeda, Yangming Xiao, Meghan Rueda, Kymberly Wimberly, Thomas Venables, Thamotharampillai Dileepan, Ellen Kraig, Ann V. Griffith
Publikováno v:
Cell Reports. 38:110363
Thymic atrophy reduces naive T cell production and contributes to increased susceptibility to viral infection with age. Expression of tissue-restricted antigen (TRA) genes also declines with age and has been thought to increase autoimmune disease sus
Autor:
Mark S. Anderson, Sergio Cepeda, Yangming Xiao, Manpreet K. Semwal, Ann V. Griffith, Thomas Venables, Stephanie Orozco, Carolina Cantu, Zoe Brown
Publikováno v:
Cell reports, vol 22, iss 5
Cell reports
Cell Reports, Vol 22, Iss 5, Pp 1276-1287 (2018)
Cell reports
Cell Reports, Vol 22, Iss 5, Pp 1276-1287 (2018)
SUMMARY Although autoimmune disorders are a significant source of morbidity and mortality in older individuals, the mechanisms governing age-associated increases in susceptibility remain incompletely understood. Central T cell tolerance is mediated t
Publikováno v:
Journal of Bioenergetics and Biomembranes. 46:323-328
Defects in Complex I assembly is one of the emerging underlying causes of severe mitochondrial disorders. The assembly of Complex I has been difficult to understand due to its large size, dual genetic control and the number of proteins involved. Muta
Catalase expression mediates redox regulation of promiscuous gene expression in thymic stromal cells
Autor:
Allison Katherine Hester, Manpreet K Semwal, Xiao Yangming, Sergio Cepeda, Thomas Venables, Ann Griffith
Publikováno v:
The Journal of Immunology. 202:65.16-65.16
The primary site for the development of T lymphocytes is the thymus, where cross-talk between thymic stromal cells (TSCs) and T cell progenitors mediates the development and maintenance of both populations. However, the thymus begins to atrophy relat