Disruption of gut barrier integrity and host–microbiome interactions underlie MASLD severity in patients with type-2 diabetes mellitus

Autor: R. Forlano, L. Martinez-Gili, P. Takis, J. Miguens-Blanco, T. Liu, E. Triantafyllou, C. Skinner, R Loomba, M. Thursz, J. R. Marchesi, B.H. Mullish, P. Manousou

Publikováno v: Gut Microbes, Vol 16, Iss 1 (2024)

ABSTRACTAberration of the “gut-liver axis” contributes to the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we use multi-omics to analyze the gut microbiota composition and metabolic profil

Externí odkaz: https://doaj.org/article/1939502f166a4f319e35ca45cc3e68b2

Multi-tissue profiling of oxylipins reveal a conserved up-regulation of epoxide:diol ratio that associates with white adipose tissue inflammation and liver steatosis in obesityResearch in context

Autor: Charlotte Hateley, Antoni Olona, Laura Halliday, Matthew L. Edin, Jeong-Hun Ko, Roberta Forlano, Ximena Terra, Fred B. Lih, Raúl Beltrán-Debón, Penelopi Manousou, Sanjay Purkayastha, Krishna Moorthy, Mark R. Thursz, Guodong Zhang, Robert D. Goldin, Darryl C. Zeldin, Enrico Petretto, Jacques Behmoaras

Publikováno v: EBioMedicine, Vol 103, Iss , Pp 105127- (2024)

Summary: Background: Obesity drives maladaptive changes in the white adipose tissue (WAT) which can progressively cause insulin resistance, type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated liver disease (MASLD). Obesity-mediated l

Externí odkaz: https://doaj.org/article/f522db65b00f4ac6b5690aad31edc432

National study of NAFLD management identifies variation in delivery of care in the UK between 2019 to 2022

Autor: Wenhao Li, David Sheridan, Stuart McPherson, William Alazawi, Kush Abeysekera, Tom Marjot, Paul Brennan, Sara Mahgoub, Tessa Cacciottolo, Theresa Hydes, Tim Hardy, Gio McGinty, Oliver Tavabie, Jennifer Cathcart, Chirantha Premathilaka, Ashis Mukhopadhya, Arshiya Bhat, Shahnaz Begum, Bashar Abushaban, Meha Bhuva, Sophie Sinclair, Damien Leith, Cullen McCulloch, Joanna Leithead, Richard Fox, Muhammad Haris Shah, Eugene Campbell, Edward Brown, Dina Mansour, Fatma Shah, Michael Allison, Jonathan Chan, Victoria Roberts, Gautham Appanna, Mandour Omer Mandour, Georgina Slee, Vicki Wong, Sreelakshmi Kotha, Katrina Pekarska, Richard Parker, Cyril Sieberhagen, Thomas Ngan, Esra Asilmaz, Hamish Miller, Jeremy Cobbold, Dom Crocombe, Manolis Tsochatzis, Sudeep Tanwar, Aruna Dias, Gurmit Singh, Swastik Agrawal, Puneet Chhabra, Amrita Gurung, Rajesh Veettil, Robin Daniel Abeles, Devnandan Chatterjee, Michael Carbonell, Zameer Mohamed, Ahmed El-Sayed, Amy Johnson, Stephen Barclay, Katherine Kelly, Joshua Munonye, Dominic Coates, Opeyemi Bamidele, Thomas Johnston, David Samuel, Belinda Ball, Rebecca Arscott-Samuel, Pamela Hams, Matthew Armstrong, Ayman Elkhol, Karanth Shailesh, Vikram Bains, Pinelopi Manousou, Tarun Gupta, Sophia Than, Esther Unitt, Victoria Gordon, Alice Wakefield, Sian Gilchrist, Ioana Cozma, Sohaib Saeed, Salman Umrani, Kathryn Olsen

Publikováno v: JHEP Reports, Vol 5, Iss 12, Pp 100897- (2023)

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is associated with liver and cardiovascular morbidity and mortality. Recently published NAFLD Quality Standards include 11 key performance indicators (KPIs) of good clinical care. This nati

Externí odkaz: https://doaj.org/article/bb54d49e02c042e2b9089458eef64e89

Non-alcoholic fatty liver disease in women – Current knowledge and emerging conceptsKey points

Autor: Pei Chia Eng, Roberta Forlano, Tricia Tan, Pinelopi Manousou, Waljit S. Dhillo, Chioma Izzi-Engbeaya

Publikováno v: JHEP Reports, Vol 5, Iss 10, Pp 100835- (2023)

Summary: Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver disease worldwide, affecting up to 30% of adults. Progression to non-alcoholic steatohepatitis (NASH) is a key risk factor for cirrhosis, hepatocellular carcinoma and cardio

Externí odkaz: https://doaj.org/article/b65ab81e2c2148f3b2f5f6de245a6c7c

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.