Comprehensive characterization of circulating tumor cells and cell‐free DNA in patients with metastatic melanoma

Autor: Manouk K. Bos, Jaco Kraan, Martijn P. A. Starmans, Jean C. A. Helmijr, Noortje Verschoor, Maja J. A. De Jonge, Arjen Joosse, Astrid A. M. van derVeldt, Peter A. W. teBoekhorst, John W. M. Martens, Stefan Sleijfer, Saskia M. Wilting

Publikováno v: Molecular Oncology, Vol 18, Iss 11, Pp 2770-2782 (2024)

Advances in therapeutic approaches for melanoma urge the need for biomarkers that can identify patients at risk for recurrence and to guide treatment. The potential use of liquid biopsies in identifying biomarkers is increasingly being recognized. He

Externí odkaz: https://doaj.org/article/38b98992e2a948ce99b5151d26f8afbd

Methylated Cell-Free DNA Sequencing (MeD-seq) of LpnPI Digested Fragments to Identify Early Progression in Metastatic Renal Cell Carcinoma Patients on Watchful Waiting

Autor: Manouk K. Bos, Sarah R. Verhoeff, Sjoukje F. Oosting, Willemien C. Menke-van der Houven van Oordt, Ruben G. Boers, Joachim B. Boers, Joost Gribnau, John W. M. Martens, Stefan Sleijfer, Carla M. L. van Herpen, Saskia M. Wilting

Publikováno v: Cancers
Volume 15
Issue 5
Pages: 1374
Cancers, 15, 5
Cancers, 15(5):1374. Multidisciplinary Digital Publishing Institute (MDPI)
Bos, M K, Verhoeff, S R, Oosting, S F, Menke-van der Houven van Oordt, W C, Boers, R G, Boers, J B, Gribnau, J, Martens, J W M, Sleijfer, S, van Herpen, C M L & Wilting, S M 2023, ' Methylated Cell-Free DNA Sequencing (MeD-seq) of LpnPI Digested Fragments to Identify Early Progression in Metastatic Renal Cell Carcinoma Patients on Watchful Waiting ', Cancers, vol. 15, no. 5, 1374 . https://doi.org/10.3390/cancers15051374
Cancers, 15(5):1374. MDPI AG
Cancers, 15

According to the current guidelines, watchful waiting (WW) is a feasible option for patients with good or intermediate prognosis renal-cell carcinoma (RCC). However, some patients rapidly progress during WW, requiring the initiation of treatment. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fccc792be5985f0cba5dab932188729

Comparison of variant allele frequency and number of mutant molecules as units of measurement for circulating tumor DNA

Autor: Manouk K. Bos, Kazem Nasserinejad, Maurice P. H. M. Jansen, Christi M.J. Steendam, Lindsay Angus, Peggy N. Atmodimedjo, Evert Jonge, Winand N. M. Dinjens, Ron H. N. Schaik, Marzia Del Re, Hendrikus J. Dubbink, Stefan Sleijfer, John W. M. Martens

Publikováno v: Molecular Oncology, Vol 15, Iss 1, Pp 57-66 (2021)
Molecular Oncology, 15(1), 57-66. John Wiley & Sons Ltd.

Quantification of tumor-specific variants (TSVs) in cell-free DNA is rapidly evolving as a prognostic and predictive tool in patients with cancer. Currently, both variant allele frequency (VAF) and number of mutant molecules per mL plasma are used as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818d730242e4bdd3fb770628baad22d9
https://pubmed.ncbi.nlm.nih.gov/34599543

Whole exome sequencing of cell-free DNA – A systematic review and Bayesian individual patient data meta-analysis

Autor: Kazem Nasserinejad, Lindsay Angus, Manouk K. Bos, John W.M. Martens, Agnes Jager, Maurice P.H.M. Jansen, Stefan Sleijfer

Publikováno v: Cancer Treatment Reviews, 83:101951. W.B. Saunders

Molecular profiling of tumor derived cell free DNA (cfDNA) is gaining ground as a prognostic and predictive biomarker. However to what extent cfDNA reflects the full metastatic landscape as currently determined by tumor tissue analysis remains contro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338ef1f98fa105923889fb65ba616da8
https://doi.org/10.1016/j.ctrv.2019.101951

Bladder preservation with brachytherapy compared to cystectomy for T1-T3 muscle-invasive bladder cancer: a systematic review

Autor: Bradley R. Pieters, Coen R. N. Rasch, Manouk K Bos, Rafael Ordoñez Marmolejo

Publikováno v: Journal of Contemporary Brachytherapy
Journal of Contemporary Brachytherapy, 6(2), 191-199. TERMEDIA PUBLISHING HOUSE LTD

Purpose: Radical cystectomy currently is the treatment of choice in muscle-invasive bladder cancer. However, cystectomy is associated with considerable morbidity. Bladder sparing treatment consists of transurethral resection of the tumor (with or wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c316b451cb2b841e3f5a7ac8cf78b25
https://doi.org/10.5114/jcb.2014.43777