Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Manoranjani P.M. Tillekeratne"'
Publikováno v:
Cancer research. 79(5)
Autor:
Runming Jin, Manoranjani P.M. Tillekeratne, Qiqi Ye, Lijun Liu, Jiang Tian, Zijian Xie, Xin Li, Peter Kometiani, Joe X. Xie, Man Liang
Publikováno v:
Journal of Biological Chemistry. 284:14921-14929
Here we show that ouabain-induced cell growth regulation is intrinsically coupled to changes in the cellular amount of Na/K-ATPase via the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway. Ouabain increases the endocy
Autor:
Sumudra Periyasamy, Weinian Shou, Manoranjani P.M. Tillekeratne, Edwin R. Sanchez, Manya Warrier
Publikováno v:
Endocrinology. 148:4716-4726
The androgen receptor (AR) contributes to growth of prostate cancer even under conditions of androgen ablation. Thus, new strategies to target AR activity are needed. The AR interacts with the immunophilin FK506-binding protein 52 (FKBP52), and studi
Publikováno v:
Cancer research. 64(7)
Tumor progression due to loss of autocrine negative transforming growth factor-β (TGF-β) activity was reported in various cancers of epithelial origin. Estrogen receptor expressing (ER+) breast cancer cells are refractory to TGF-β effects and exhi
Autor:
Michael G. Brattain, Sumudra Periyasamy, Sudhakar Ammanamanchi, Manoranjani P.M. Tillekeratne
Publikováno v:
Oncogene. 19(40)
In this report, we describe the mechanism of TGF-beta receptor type I (RI) repression in the GEO human colon carcinoma cells. Treatment of GEO cells with the DNA methyltransferase inhibitor, 5 azacytidine induced RI expression and restored TGF-beta r