Zobrazeno 1 - 2
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pro vyhledávání: '"Manon Nassar"'
Publikováno v:
ACS chemical biology. 17(8)
Modular fluorescent sensor motifs are needed to design fluorescent sensors for detecting various cellular processes and functional molecules. Here, we took advantage of the versatility of a new sensor motif to design a series of sensors called SPOTon
Autor:
May H. Abdel Aziz, Kendall Cooper, Ramsha Imran, Allison Sunderhaus, Manon Nassar, Dustin P. Patterson, Amanda Goudelock
Publikováno v:
Biotechnology and Bioengineering. 118:1466-1475
Epidermal growth factor receptor (EGFR) is a clinically validated target for a multitude of human cancers. The receptor is activated upon ligand binding through a critical dimerization step. Dimerization can be replicated in vitro by locally concentr