Structural study of bioisosteric derivatives of 5-(1H-indol-3-yl)-benzotriazole and their ability to form chalcogen bonds

Autor: Manon Mirgaux, Tanguy Scaillet, Arina Kozlova, Nikolay Tumanov, Raphaël Frederick, Laurie Bodart, Johan Wouters

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 78, Iss 4, Pp 418-424 (2022)

Recently, interest in the isosteric replacement of a nitrogen atom to selenium, sulfur or oxygen atoms has been highlighted in the design of potential inhibitors for cancer research. In this context, the structures of 5-(1H-indol-3-yl)-2,1,3-benzotri

Externí odkaz: https://doaj.org/article/8439de2cfcb8490baac398c80349d671

Temporary Intermediates of L-Trp Along the Reaction Pathway of human Indoleamine 2,3-dioxygenase 1 and Identification of an Exo Site

Autor: Manon Mirgaux, Laurence Leherte, Johan Wouters

Publikováno v: Mirgaux, M, Leherte, L & Wouters, J 2021, ' Temporary Intermediates of L-Trp Along the Reaction Pathway of human Indoleamine 2,3-dioxygenase 1 and Identification of an Exo Site ', International Journal of Tryptophan Research, vol. 14, pp. 1-11 . https://doi.org/10.1177/11786469211052964
International Journal of Tryptophan Research : IJTR
International Journal of Tryptophan Research, Vol 14 (2021)

Protein dynamics governs most of the fundamental processes in the human body. Particularly, the dynamics of loops located nearan active site can be involved in the positioning of the substrate and the reaction mechanism. The understanding of the func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95895590320cc64f0255142c9d7ab69d
https://pure.unamur.be/ws/files/61998089/ArticleFinal.pdf

Influence of the presence of the heme cofactor on the JK-loop structure in indoleamine-2,3-dioxygenase-1

Autor: Johan Wouters, Manon Mirgaux, Laurence Leherte

Publikováno v: Mirgaux, M, Leherte, L & Wouters, J 2020, ' Influence of the presence of the heme cofactor on the JK-loop structure in indoleamine-2,3-dioxygenase-1 ', Acta crystallographica. Section D: Structural Biology, vol. 76, pp. 1211-1221 . https://doi.org/10.1107/S2059798320013510

Indoleamine 2,3-dioxygenase 1 has sparked interest as an immunotherapeutictarget in cancer research. Its structure includes a loop, named the JK-loop, thatcontrols the orientation of the substrate or inhibitor within the active site.However, little h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1aea99978399e7909dd482461b2abd
https://pure.unamur.be/ws/files/53018589/publi_ido.pdf

Influence of the presence of the heme cofactor on the JK‐loop structure in indoleamine 2,3‐dioxygenase 1.

Autor: Mirgaux, Manon¹ (AUTHOR) manon.mirgaux@unamur.be, Leherte, Laurence¹ (AUTHOR), Wouters, Johan¹ (AUTHOR) johan.wouters@unamur.be

Publikováno v: Acta Crystallographica: Section D, Structural Biology. Dec2020, Vol. 76 Issue 12, p1211-1221. 11p.

HPC + in the medical field: Overview and current examples.

Autor: Koch, Miriam¹ (AUTHOR) koch@hlrs.de, Arlandini, Claudio² (AUTHOR), Antonopoulos, Gregory³ (AUTHOR), Baretta, Alessia⁴ (AUTHOR), Beaujean, Pierre⁵ (AUTHOR), Bex, Geert Jan⁶ (AUTHOR), Biancolini, Marco Evangelos⁷ (AUTHOR), Celi, Simona⁸ (AUTHOR), Costa, Emiliano⁹ (AUTHOR), Drescher, Lukas¹⁰ (AUTHOR), Eleftheriadis, Vasileios¹¹ (AUTHOR), Fadel, Nur A.¹⁰ (AUTHOR), Fink, Andreas¹⁰ (AUTHOR), Galbiati, Federica⁹ (AUTHOR), Hatzakis, Ilias¹² (AUTHOR), Hompis, Georgios³ (AUTHOR), Lewandowski, Natalie¹ (AUTHOR), Memmolo, Antonio² (AUTHOR), Mensch, Carl¹³ (AUTHOR), Obrist, Dominik¹⁴ (AUTHOR)

Publikováno v: Technology & Health Care. 2023, Vol. 31 Issue 4, p1509-1523. 15p.