Výsledky vyhledávání - "Manon M. H. Huibers"

Akademický článek

Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner

Autor: Monika M. Gladka, Arwa Kohela, Bas Molenaar, Danielle Versteeg, Lieneke Kooijman, Jantine Monshouwer-Kloots, Veerle Kremer, Harmjan R. Vos, Manon M. H. Huibers, Jody J. Haigh, Danny Huylebroeck, Reinier A. Boon, Mauro Giacca, Eva van Rooij

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

ZEB2 transcription factor is increased in a subset of cardiomyocytes during stress to induce cardioprotective effects after injury. Here the authors show that therapeutic delivery of ZEB2 prevents cardiac dysfunction after ischemic damage and promote

Externí odkaz: https://doaj.org/article/802a0b24eda04cdd86b100e349bc9eb1

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Akademický článek

Implementation of Early Next-Generation Sequencing for Inborn Errors of Immunity: A Prospective Observational Cohort Study of Diagnostic Yield and Clinical Implications in Dutch Genome Diagnostic Centers

Autor: Kim Elsink, Manon M. H. Huibers, Iris H. I. M. Hollink, Annet Simons, Evelien Zonneveld-Huijssoon, Lars T. van der Veken, Helen L. Leavis, Stefanie S. V. Henriet, Marcel van Deuren, Frank L. van de Veerdonk, Judith Potjewijd, Dagmar Berghuis, Virgil A. S. H. Dalm, Clementien L. Vermont, Annick A. J. M. van de Ven, Annechien J. A. Lambeck, Kristin M. Abbott, P. Martin van Hagen, Godelieve J. de Bree, Taco W. Kuijpers, Geert W. J. Frederix, Mariëlle E. van Gijn, Joris M. van Montfrans, the Genetics First for Primary Immunodeficiency Disorders Consortium, Aerde van, KJ, Altenburg, J, Armbrust W, Barendregt, BH, Berg van den, JM, Bredius, RGM, Buddingh, EP, Burg van der, M, Ellerbroek, PM, Ernst, RF, Fraaij, PLA, Hermans, M, Hoischen, A, Hout van der, AH, Jansen, MHA, Jolink, H, Jonkers, RE, Laar van, JAM, Leeuw de, K, Legger, GE, Leijten, EFA, Limper, M, Lindemans, CA, Oever ten, J, Pieterse, M, Rombach, SM, Rossum van, AMC, Rutgers, A, Santen, GWE, Schölvinck, EH, Simon, A, Stol, K, Vervenne RML

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

ObjectiveInborn errors of immunity (IEI) are a heterogeneous group of disorders, affecting different components of the immune system. Over 450 IEI related genes have been identified, with new genes continually being recognized. This makes the early a

Externí odkaz: https://doaj.org/article/1589a20c7b90482f8384cabc050aeb63

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Akademický článek

Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival

Autor: Patricia van den Hoogen, Manon M. H. Huibers, Floor W. van den Dolder, Roel de Weger, Erica Siera-de Koning, Marish I. F. Oerlemans, Nicolaas de Jonge, Linda W. van Laake, Pieter A. Doevendans, Joost. P. G. Sluijter, Aryan Vink, Saskia C. A. de Jager

Publikováno v: Biology, Vol 12, Iss 1, p 61 (2022)

Cardiac allograft vasculopathy (CAV) and antibody-mediated rejection are immune-mediated, long-term complications that jeopardize graft survival after heart transplantation (HTx). Interestingly, increased plasma levels of immunoglobulins have been fo

Externí odkaz: https://doaj.org/article/052311861a394f7db06126baef2e60c0

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Akademický článek

One-fits-all pretreatment protocol facilitating Fluorescence In Situ Hybridization on formalin-fixed paraffin-embedded, fresh frozen and cytological slides

Autor: Shivanand O. Richardson, Manon M. H. Huibers, Roel A. de Weger, Wendy W. J. de Leng, John W. J. Hinrichs, Ruud W. J. Meijers, Stefan M. Willems, Ton L. M. G. Peeters

Publikováno v: Molecular Cytogenetics, Vol 12, Iss 1, Pp 1-10 (2019)

Abstract Background The Fluorescence In Situ Hybridization (FISH) technique is a very useful tool for diagnostic and prognostic purposes in molecular pathology. However, clinical testing on patient tissue is challenging due to variables of tissue pro

Externí odkaz: https://doaj.org/article/95496c3b8ec54bfa951f5d85ad793295

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Akademický článek

Droplet digital PCR for detection and quantification of circulating tumor DNA in plasma of head and neck cancer patients

Autor: Joost H. van Ginkel, Manon M. H. Huibers, Robert J. J. van Es, Remco de Bree, Stefan M. Willems

Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-8 (2017)

Abstract Background During posttreatment surveillance of head and neck cancer patients, imaging is insufficiently accurate for the early detection of relapsing disease. Free circulating tumor DNA (ctDNA) may serve as a novel biomarker for monitoring

Externí odkaz: https://doaj.org/article/d204da77a5c340bd96a93e95c5ad694a

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Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival

Publikováno v: van den Hoogen, P, Huibers, M M H, van den Dolder, F W, de Weger, R, Siera-de Koning, E, Oerlemans, M I F, de Jonge, N, van Laake, L W, Doevendans, P A, Sluijter, J P G, Vink, A & de Jager, S C A 2023, ' Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival ', Biology, vol. 12, no. 1, 61 . https://doi.org/10.3390/biology12010061
Biology, 12(1):61. Multidisciplinary Digital Publishing Institute (MDPI)
Biology; Volume 12; Issue 1; Pages: 61

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796d56d2c5c38acc24beff5c32a7d814
http://www.scopus.com/inward/record.url?scp=85146744037&partnerID=8YFLogxK

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Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner

Autor: Mauro Giacca, Eva van Rooij, Danny Huylebroeck, Manon M. H. Huibers, Jody J. Haigh, D Versteeg, Reinier A. Boon, Bas Molenaar, Monika M Gladka, Veerle Kremer, Harmjan R. Vos, Arwa Kohela, Lieneke Kooijman, Jantine Monshouwer-Kloots

Publikováno v: Nature communications, 12(1):84. Nature Publishing Group
Nature Communications, 12(1):84. Nature Publishing Group
Gladka, M M, Kohela, A, Molenaar, B, Versteeg, D, Kooijman, L, Monshouwer-Kloots, J, Kremer, V, Vos, H R, Huibers, M M H, Haigh, J J, Huylebroeck, D, Boon, R A, Giacca, M & van Rooij, E 2021, ' Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner ', Nature Communications, vol. 12, no. 1, 84 . https://doi.org/10.1038/s41467-020-20361-3
Nature Communications, 12(1). Nature Publishing Group
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

The disruption in blood supply due to myocardial infarction is a critical determinant for infarct size and subsequent deterioration in function. The identification of factors that enhance cardiac repair by the restoration of the vascular network is,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62d8375518baddb52a2176422af68d4
https://pure.amc.nl/en/publications/cardiomyocytes-stimulate-angiogenesis-after-ischemic-injury-in-a-zeb2dependent-manner(d774f618-8c07-4fcf-952a-a6da54359840).html

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Akademický článek

MicroRNA Expression in Myocardial Tissue and Plasma of Patients with End-Stage Heart Failure during LVAD Support: Comparison of Continuous and Pulsatile Devices.

Autor: Sjoukje I Lok, Nicolaas de Jonge, Joyce van Kuik, Ankie J P van Geffen, Manon M H Huibers, Petra van der Weide, Erica Siera, Bjorn Winkens, Pieter A Doevendans, Roel A de Weger, Paula A da Costa Martins

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0136404 (2015)

Pulsatile flow left ventricular assist devices (pf-LVADs) are being replaced by continuous flow LVADs (cf-LVADs) in patients with end-stage heart failure (HF). MicroRNAs (miRs) play an important role in the onset and progression of HF. Our aim was to

Externí odkaz: https://doaj.org/article/c809b2ed452e4d09916bc4b0273cc239

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A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration

Publikováno v: Nature Communications, 12(1):4808. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications

Myocardial regeneration is restricted to early postnatal life, when mammalian cardiomyocytes still retain the ability to proliferate. The molecular cues that induce cell cycle arrest of neonatal cardiomyocytes towards terminally differentiated adult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b06b6cc7a973149412b1f4be9647a90
https://doi.org/10.1038/s41467-021-25211-4

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National external quality assessment for next-generation sequencing-based diagnostics of primary immunodeficiencies

Autor: Marielle E. van Gijn, Kristin M. Abbott, Alexander Hoischen, Robert F Ernst, Manon M. H. Huibers, Kim Elsink, Taco W. Kuijpers, Evelien Zonneveld-Huijssoon, Lars T. van der Veken, Joris M. van Montfrans, Marc Pieterse, Iris H.I.M. Hollink, Annemieke H. van der Hout, Annet Simons

Publikováno v: European Journal of Human Genetics, 20-28. Nature Publishing Group
ISSUE=1;STARTPAGE=20;ENDPAGE=28;ISSN=1018-4813;TITLE=European Journal of Human Genetics
European Journal of Human Genetics, 29, 1, pp. 20-28
Eur J Hum Genet
European Journal of Human Genetics, 29(1), 20-28. Nature Publishing Group
European Journal of Human Genetics, 29, 20-28
European journal of human genetics, 29(1), 20-28. Nature Publishing Group

Contains fulltext : 231689.pdf (Publisher’s version ) (Closed access) Dutch genome diagnostic centers (GDC) use next-generation sequencing (NGS)-based diagnostic applications for the diagnosis of primary immunodeficiencies (PIDs). The interpretatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a021cc16bf91f1943b9688ac2cad7136
https://research.rug.nl/en/publications/1daac6ef-fd44-4f1c-b450-8ac07ec3dcfc

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