Výsledky vyhledávání - "Manon Fleurent"

New 1,2,3,4-tetrahydropyrrolo[3,4-b]indole derivatives as selective CB2 receptor agonists

Autor: Page Daniel, Christopher Walpole, François Gaudreault, Meredith Fyfe, Hua Yang, Manon Fleurent, Stephane St-Onge, William Brown

Publikováno v: Bioorganicmedicinal chemistry letters. 17(22)

The preparation and evaluation of a novel class of CB2 agonists based on a 1,2,3,4-tetrahydropyrrolo[3,4-b]indole moiety are reported. They showed binding affinities up to 4.2 nM toward CB2 with sub-nanomolar EC50 values. They also showed moderate to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13002dd9d03208d0da7bfdc7ac12b204
https://pubmed.ncbi.nlm.nih.gov/17884494

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Angiotensin II stimulates phosphorylation of the translational repressor 4E-binding protein 1 by a mitogen-activated protein kinase-independent mechanism

Autor: Sylvain Meloche, Manon Fleurent, Anne-Claude Gingras, Nahum Sonenberg

Publikováno v: ResearcherID

To investigate the molecular basis of the hypertrophic action of angiotensin II (AII) in vascular smooth muscle cells (SMC), we have examined the ability of the hormone to regulate the function of the translational repressor 4E-binding protein 1 (4E-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011f2f27f29cca1d46b72c8c260f8b22
https://www.ncbi.nlm.nih.gov/pubmed/9020107

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