Zobrazeno 1 - 10 of 159 pro vyhledávání: '"Manon E Wildenberg"'
1
Akademický článek
A distinct epigenetic profile distinguishes stenotic from non-inflamed fibroblasts in the ileal mucosa of Crohn's disease patients.
Autor: Andrew Y F Li Yim, Jessica R de Bruyn, Nicolette W Duijvis, Catriona Sharp, Enrico Ferrero, Wouter J de Jonge, Manon E Wildenberg, Marcel M A M Mannens, Christianne J Buskens, Geert R D'Haens, Peter Henneman, Anje A Te Velde
Publikováno v: PLoS ONE, Vol 13, Iss 12, p e0209656 (2018)
BackgroundThe chronic remitting and relapsing intestinal inflammation characteristic of Crohn's disease frequently leads to fibrosis and subsequent stenosis of the inflamed region. Approximately a third of all Crohn's disease patients require resecti
Externí odkaz: https://doaj.org/article/4d247c38076e4a7984fa3ae11f10c912
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2
Akademický článek
A practice-changing culture method relying on shaking substantially increases mitochondrial energy metabolism and functionality of human liver cell lines.
Autor: Aziza A A Adam, Vincent A van der Mark, Joanne M Donkers, Manon E Wildenberg, Ronald P J Oude Elferink, Robert A F M Chamuleau, Ruurdtje Hoekstra
Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0193664 (2018)
Practice-changing culturing techniques of hepatocytes are highly required to increase their differentiation. Previously, we found that human liver cell lines HepaRG and C3A acquire higher functionality and increased mitochondrial biogenesis when cult
Externí odkaz: https://doaj.org/article/dda135b9f4ac477fa76ca8c842d09a26
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3
Akademický článek
Intestinal fibrosis is associated with lack of response to Infliximab therapy in Crohn's disease.
Autor: Jessica R de Bruyn, Marte A Becker, Jessica Steenkamer, Manon E Wildenberg, Sybren L Meijer, Christianne J Buskens, Willem A Bemelman, Mark Löwenberg, Cyriel Y Ponsioen, Gijs R van den Brink, Geert R D'Haens
Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0190999 (2018)
Overt fibrostenotic disease is a relative contraindication for anti-TNF therapy in Crohn's disease. We hypothesized that subclinical fibrosis may also contribute to an incomplete response to anti-TNF therapy before the onset of symptomatic stenosis.I
Externí odkaz: https://doaj.org/article/a23a1cc59d27494d855c8b82973cb9d8
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4
Akademický článek
T-cell responses in colorectal peritoneal metastases are recapitulated in a humanized immune system mouse model
Autor: Job Saris, Sanne Bootsma, Jan Verhoeff, Jurriaan B. Tuynman, Manon E. Wildenberg, Esther Siteur-van Rijnstra, Kristiaan J. Lenos, Juan J. Garcia Vallejo, Louis Vermeulen, Joep Grootjans
Publikováno v: Frontiers in Immunology, Vol 15 (2024)
BackgroundThe occurrence of peritoneal metastasis (PM) in patients with colorectal cancer (CRC) has a dismal prognosis. There is often limited response to systemic- and immunotherapy, even in microsatellite unstable (MSI) CRC. To overcome therapy res
Externí odkaz: https://doaj.org/article/0db70c82f5d3425981c96647ff398c29
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5
Akademický článek
Pro-inflammatory T cells-derived cytokines enhance the maturation of the human fetal intestinal epithelial barrier
Autor: Francesca P. Giugliano, Marit Navis, Sarah Ouahoud, Tânia Martins Garcia, Irini A.M. Kreulen, Evelina Ferrantelli, Sander Meisner, Jacqueline L.M. Vermeulen, Manon van Roest, Jean-Noël Billaud, Jan Koster, Yousif Dawood, Bernadette S. de Bakker, Daisy I. Picavet-Havik, Irene M. Schimmel, Nicole N. van der Wel, Pim J. Koelink, Manon E. Wildenberg, Joep P.M. Derikx, Wouter J. de Jonge, Ingrid B. Renes, Ruurd M. van Elburg, Vanesa Muncan
Publikováno v: iScience, Vol 27, Iss 6, Pp 109909- (2024)
Summary: Small intestine (SI) maturation during early life is pivotal in preventing the onset of gut diseases. In this study we interrogated the milestones of SI development by gene expression profiling and ingenuity pathway analyses. We identified a
Externí odkaz: https://doaj.org/article/471bf6ea022848e0a4e16b1d7e10442e
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6
Akademický článek
Berbamine suppresses intestinal SARS-CoV-2 infection via a BNIP3-dependent autophagy blockade
Autor: Alexandra P. M. Cloherty, Anusca G. Rader, Kharishma S. Patel, Jimena Pérez-Vargas, Connor A. H. Thompson, Siobhan Ennis, Masahiro Niikura, Manon E. Wildenberg, Vanesa Muncan, Renée R. C. E. Schreurs, François Jean, Carla M. S. Ribeiro
Publikováno v: Emerging Microbes and Infections, Vol 12, Iss 1 (2023)
ABSTRACTSARS-CoV-2, the causative virus of COVID-19, continues to threaten global public health. COVID-19 is a multi-organ disease, causing not only respiratory distress, but also extrapulmonary manifestations, including gastrointestinal symptoms wit
Externí odkaz: https://doaj.org/article/20a7f625903a4849b595ebef82383493
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7
Role of the Mesentery in Crohn's Terminal Ileitis
Autor: Marte A.J. Becker, Eline M.L. van der Does de Willebois, Willem A. Bemelman, Manon E. Wildenberg, Christianne J. Buskens
Publikováno v: Clin Colon Rectal Surg
Clinics in colon and rectal surgery, 35(4), 316-320. Thieme Medical Publishers
Despite the longstanding awareness of the presence of mesenteric alterations in Crohn's disease, the functional and clinical consequences of these alterations remain a topic of debate. Guidelines advise a limited resection without resection of the ad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd497f09d11f8f12e216cf8cb72ba2b
http://www.scopus.com/inward/record.url?scp=85133957729&partnerID=8YFLogxK
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