Výsledky vyhledávání - "Manon C. Verhoeven"

Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2

Autor: Gilbert Weidinger, Jeroen Bakkers, Manon C. Verhoeven, Christa Haase, Vincent M. Christoffels

Publikováno v: Birth defects research. Part A, Clinical and molecular teratology, 91(6), 435-440. Wiley-Liss Inc.
Birth Defects Research Part A: Clinical and Molecular Teratology, 91(6), 435-440. Wiley-Liss Inc.

In the developing heart, the atrioventricular canal (AVC) is essential for separation and alignment of the cardiac chambers, for valve formation, and serves to delay the electrical impulse from the atria to the ventricles. Defects in various aspects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff954d536ccd8c3d5597abc83c0eba84
https://doi.org/10.1002/bdra.20804

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Zebrafish Bmp4 regulates left–right asymmetry at two distinct developmental time points

Autor: Fabian Rentzsch, Sonja Chocron, Jeroen Bakkers, Manon C. Verhoeven, Matthias Hammerschmidt

Publikováno v: Developmental Biology. 305(2):577-588

Left-right (LR) asymmetry is regulated by early asymmetric signals within the embryo. Even though the role of the bone morphogenetic protein (BMP) pathway in this process has been reported extensively in various model organisms, opposing models for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514ad24acf16970252fe4b353e38f899

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The Androgen Receptor Recruits Nuclear Receptor CoRepressor (N-CoR) in the Presence of Mifepristone via Its N and C Termini Revealing a Novel Molecular Mechanism for Androgen Receptor Antagonists

Autor: Eunis Choi, Inna Astapova, Myles C. Hodgson, Manon C. Verhoeven, Shinta Cheng, Larissa J. Lee, Steven P. Balk, Anthony N. Hollenberg

Publikováno v: Journal of Biological Chemistry. 280:6511-6519

The androgen receptor (AR) activates target gene expression in the presence of agonist ligands via the recruitment of transcriptional coactivators, but recent work shows that overexpression of the nuclear corepressors NCoR and SMRT attenuates this ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897f9ac4d7026698be65fe07e4aeb250
https://doi.org/10.1074/jbc.m408972200

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A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality

Autor: Suma Choorapoikayil, Federico Tessadori, Emily S. Noël, Jeroen Bakkers, Manon C. Verhoeven, Kelly A. Smith, Anne K. Lagendijk, Jeroen den Hertog

Publikováno v: Nature Communications, 4. Nature Publishing Group

Breaking left-right symmetry in bilateria is a major event during embryo development that is required for asymmetric organ position, directional organ looping and lateralized organ function in the adult. Asymmetric expression of Nodal-related genes i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbcc0b9339b0bbc6502a89381ba6ada
https://hdl.handle.net/20.500.11755/348a5bc2-4240-4742-b72b-88afa3691c5a

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Dominant-negative ALK2 allele associates with congenital heart defects

Autor: Joeroen Bakkers, Barbara J.M. Mulder, Kelly A. Smith, Manon C. Verhoeven, Pieter A. Doevendans, Victor Guryev, Holger Rehmann, Irene C. Joziasse, Peter ten Dijke, Edwin Cuppen, Sonja Chocron, Jasper J. van der Smagt, Maarten van Dinther

Publikováno v: Circulation, 119(24), 3062-9. LIPPINCOTT WILLIAMS & WILKINS
Circulation, 119(24), 3062-3069. Lippincott Williams and Wilkins
Circulation, 119(24), 3062-3069. Lippincott Williams & Wilkins

Background— Serious congenital heart defects occur as a result of improper atrioventricular septum (AVS) development during embryogenesis. Despite extensive knowledge of the genetic control of AVS development, few genetic lesions have been identifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae40a09c1c3323fadba404744a66fc3
https://research.rug.nl/en/publications/4dbc31db-91e8-4c58-973d-4faaf754028c

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Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells

Autor: Manon C. Verhoeven, Shaoyong Chen, Steven P. Balk, Youyuan Xu, David Masiello, Anthony N. Hollenberg, Eunis Choi

Publikováno v: Molecular endocrinology (Baltimore, Md.). 18(10)

Prostate cancers respond to treatments that suppress androgen receptor (AR) function, with bicalutamide, flutamide, and cyproterone acetate (CPA) being AR antagonists in clinical use. As CPA has substantial agonist activity, it was examined to identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a907eb5ea6b1e527c9ddb5dc7b7fbc25
https://pubmed.ncbi.nlm.nih.gov/15256534

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