Výsledky vyhledávání - "Manon, Strehaiano"

Akademický článek

FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 11, Pp 1-23 (2020)

Abstract Cancer‐associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour progression and chemoresistance; however, a druggable target on CAFs

Externí odkaz: https://doaj.org/article/813c0054a8534fda924f316a50f89572

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FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer

Publikováno v: EMBO Molecular Medicine
EMBO Molecular Medicine, Wiley Open Access, 2020, 12 (11), ⟨10.15252/emmm.202012010⟩
EMBO Molecular Medicine, Vol 12, Iss 11, Pp n/a-n/a (2020)

Cancer‐associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour progression and chemoresistance; however, a druggable target on CAFs has not y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f6a5f784f2a9a2332b4035901ba368
https://doi.org/10.15252/emmm.202012010

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eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer

Autor: Romain Baer, Laia Masvidal-Sanz, Sauyeun Shin, Julie Guillermet-Guibert, Manon Strehaiano, Yoshinori Tsukumo, Corinne Bousquet, Nahum Sonenberg, Ola Larsson, Stéphane Pyronnet, Nicolas Guilbaud, Yvan Martineau, Jean-Sébastien Hoffmann, Théo Goullet de Rugy, Frédéric Marion, David Müller, Christine Jean, Rémi Samain

Publikováno v: JCI Insight. 4

Pancreatic ductal adenocarcinoma (PDAC) relies on hyperactivated protein synthesis. Consistently, human and mouse PDAC lose expression of the translational repressor and mTOR target 4E-BP1. Using genome-wide polysome profiling, we here explore mRNAs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c19ad875afea3b560aa3a9ce792dbf9
https://doi.org/10.1172/jci.insight.121951

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Neuroprotection in non-transgenic and transgenic mouse models of Alzheimer's disease by positive modulation of σ1 receptors

Autor: Tangui Maurice, David Virieux, Claire Pereira, Nikolay Kaloyanov, Jean-Noël Volle, Lucie Crouzier, Manon Strehaiano, Jean-Luc Pirat

Publikováno v: Pharmacological Research
Pharmacological Research, 2019, 144, pp.315-330. ⟨10.1016/j.phrs.2019.04.026⟩
Pharmacological Research, Elsevier, 2019, 144, pp.315-330. ⟨10.1016/j.phrs.2019.04.026⟩

International audience; The sigma-1 (σ1) receptor is an endoplasmic reticulum (ER) chaperone protein, enriched in mitochondria-associated membranes. Its activation triggers physiological responses to ER stress and modulate Ca2+ mobilization in mitoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70783c51a1ce73f0a35af16c4ebd1cf
https://hal.science/hal-02272972/file/S1043661818320267.pdf

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Amyloid toxicity is enhanced after pharmacological or genetic invalidation of the σ 1 receptor

Autor: Fanny Duhr, Manon Strehaiano, Nathalie Chevallier, Tangui Maurice

Publikováno v: Behavioural Brain Research
Behavioural Brain Research, Elsevier, 2018, 339, pp.1-10. ⟨10.1016/j.bbr.2017.11.010⟩

The sigma-1 receptor (S1R) is a molecular chaperone which activity modulates several intracellular signals including calcium mobilization at mitochondria-associated endoplasmic reticulum membranes. S1R agonists are potent neuroprotectants against neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9120196785e1e64858bc470259648dc
https://hal.archives-ouvertes.fr/hal-01922562

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Learning performances and vulnerability to amyloid toxicity in the butyrylcholinesterase knockout mouse

Autor: Christelle Bertrand, Manon Strehaiano, Tangui Maurice, Nathalie Siméon, Arnaud Chatonnet

Publikováno v: Behavioural Brain Research
Behavioural Brain Research, Elsevier, 2016, 296, pp.351-360. ⟨10.1016/j.bbr.2015.08.026⟩

Butyrylcholinesterase (BChE) is an important enzyme for detoxication and metabolism of ester compounds. It also hydrolyzes the neurotransmitter acetylcholine (ACh) in pathological conditions and may play a role in Alzheimer's disease (AD). We here co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a8c3c200b79569d44860c9d67cbf57
https://doi.org/10.1016/j.bbr.2015.08.026

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Amyloid toxicity is enhanced after pharmacological or genetic invalidation of the σ

Autor: Tangui, Maurice, Manon, Strehaiano, Fanny, Duhr, Nathalie, Chevallier

Publikováno v: Behavioural brain research. 339

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3813f8683db2945d17bffc4207f043b
https://pubmed.ncbi.nlm.nih.gov/29129596

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An Intranasal Formulation of Erythropoietin (Neuro-EPO) Prevents Memory Deficits and Amyloid Toxicity in the APPSwe Transgenic Mouse Model of Alzheimer's Disease

Autor: Manon Strehaiano, Yamila Rodríguez Cruz, Tangui Maurice, Julio César García Rodríguez, Teresita Rodriguez Obaya

Publikováno v: Journal of Alzheimer's Disease
Journal of Alzheimer's Disease, IOS Press, 2016, 55 (1), pp.231-248. ⟨10.3233/JAD-160500⟩

Erythropoietin (EPO) is a cytokine known to have effective cytoprotective action in the brain, particularly in ischemic, traumatic, inflammatory, and neurodegenerative conditions. We previously reported the neuroprotective effect of a low sialic form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce24b60eadef39314b79eec278e7ef2
https://pubmed.ncbi.nlm.nih.gov/27662300

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