Výsledky vyhledávání - "Manolya Kukut"

Development and validation of a reverse phase HPLC method for SHetA2, a novel anti-cancer drug, in mouse biological samples

Autor: Manolya Kukut Hatipoglu, Lucila Garcia-Contreras, Sanjida Mahjabeen

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 170:124-131

SHetA2 is a flexible heteroarotinoid that has the potential to prevent and treat lung, ovarian and cervical cancer without significant toxicity. A simple and reliable high performance liquid chromatographic (HPLC) method was developed to determine SH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e1fa88ba7f2313c3098cc9d2953ee5
https://doi.org/10.1016/j.jpba.2019.03.037

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Development of a dietary formulation of the SHetA2 chemoprevention drug for mice

Autor: Stan Lighfoot, Chinthalapally V. Rao, Naveena B. Janakiram, Gopal Pathuri, Lucila Garcia-Contreras, Doris M. Benbrook, Venkateshwar Madka, Vishal Chandra, Manolya Kukut Hatipoglu, Cassadie N Farnsworth, Chioniso P. Masamha, Nicole Stratton

Publikováno v: Investigational New Drugs

Summary Development of cancer chemoprevention compounds requires enhanced consideration for toxicity and route of administration because the target population is healthy. The small molecule drug, SHetA2 (NSC 726189), exhibited in vivo chemoprevention

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228ea9fc7d1958329134c386cab42239
http://europepmc.org/articles/PMC6014882

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Vaginal Suppositories Containing SHetA2 to Treat Cervical Dysplasia: Pharmacokinetics of Daily Doses and Preliminary Safety Profile

Autor: David Garcia-Contreras, Lucila Garcia-Contreras, Manolya Kukut Hatipoglu, Doris M. Benbrook, Stanley D. Kosanke, Sanjida Mahjabeen

Publikováno v: J Pharm Sci

SHetA2 is a new drug with potential to treat cervical dysplasia, but only 0.02% of the dose is absorbed into the cervix after oral administration. By contrast, 23.9% of the dose is absorbed into the cervix after vaginal administration. This study det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea42fa57efe6352dcd58b30580195cb
https://pubmed.ncbi.nlm.nih.gov/32113976

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Akademický článek

Synthesis and Biological Use of Nanomaterials.

Autor: Hatipoglu, Manolya Kukut, Sut, Pinar Akkus

Publikováno v: Topics in Applied Physics; 2021, Vol. 144, p793-858, 66p

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Abstract PO040: Chemoprevention and regression of estrogen-induced atypical endometrial hyperplasia by oral SHetA2 in a rat model

Autor: Manolya Kukut Hatipoglu, Vishal Chandra, Doris M. Benbrook, Rajani Rai, Stan S. Lightfoot, Lucila Garcia-Contreras

Publikováno v: Clinical Cancer Research. 27:PO040-PO040

Introduction: The purpose was to evaluate the chemoprevention efficacy of SHetA2 (NSC 726189) in a rat model of atypical endometrial hyperplasia (AEH). Methods: Female Sprague Dawley rats were ovariectomized, rested for 2 weeks, and subcutaneously im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d7d6bf2e1a32964931674681bd755e7
https://doi.org/10.1158/1557-3265.endomet20-po040

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Abstract 27: Development of a rat model of atypical endometrial hyperplasia and a vaginal suppository formulation of SHetA2 for chemoprevention studies

Autor: Lucila Garcia, Manolya Kukut Hatipoglu, Rajani Rai, Sanam Hussain, Doris M. Benbrook, Vishal Chandra

Publikováno v: Cancer Research. 80:27-27

Introduction: The purposes were to develop a rat model of atypical endometrial hyperplasia and a vaginal suppository of the drug SHetA2 (NSC 726189) for use in a chemoprevention study. Methods: Female Sprague Dawley rats (150-250 g) were ovariectomiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b4284d2ba89b36470515c1b2e3458fc
https://doi.org/10.1158/1538-7445.am2020-27

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Cryogenic Fabrication of Dry Powders to Enhance the Solubility of a Promising Anticancer Drug, SHetA2, for Oral Administration

Autor: Manolya Kukut Hatipoglu, Mariam Ibrahim, Lucila Garcia-Contreras

Publikováno v: AAPS PharmSciTech. 20(1)

SHetA2 is a novel anticancer drug with poor aqueous solubility. In formal toxicological studies, Kolliphor HS 15 was used as a solubilizing agent to increase the oral bioavailability of SHetA2. The purpose of this study was to formulate SHetA2 and Ko

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8de7a0a4603c1fd32f721e7b194d97
https://pubmed.ncbi.nlm.nih.gov/30604109

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