Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Manolis Maragkakis"'
Autor:
James R. Occean, Na Yang, Yan Sun, Marshall S. Dawkins, Rachel Munk, Cedric Belair, Showkat Dar, Carlos Anerillas, Lin Wang, Changyou Shi, Christopher Dunn, Michel Bernier, Nathan L. Price, Julie S. Kim, Chang-Yi Cui, Jinshui Fan, Moitrayee Bhattacharyya, Supriyo De, Manolis Maragkakis, Rafael de Cabo, Simone Sidoli, Payel Sen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract DNA hydroxymethylation (5hmC), the most abundant oxidative derivative of DNA methylation, is typically enriched at enhancers and gene bodies of transcriptionally active and tissue-specific genes. Although aberrant genomic 5hmC has been impli
Externí odkaz:
https://doaj.org/article/afa1a93ab0c44eaca0dfd46fe91a1ae3
Autor:
Yongjuan Guan, Hongyan Gao, N Adrian Leu, Anastassios Vourekas, Panagiotis Alexiou, Manolis Maragkakis, Zhenlong Kang, Zissimos Mourelatos, Guanxiang Liang, P Jeremy Wang
Publikováno v:
PLoS Genetics, Vol 19, Iss 5, p e1010566 (2023)
Transposable elements constitute nearly half of the mammalian genome and play important roles in genome evolution. While a multitude of both transcriptional and post-transcriptional mechanisms exist to silence transposable elements, control of transp
Externí odkaz:
https://doaj.org/article/6fb3ccb1c174425a95ff36753cfe0893
Autor:
Christopher T. Lee, Manolis Maragkakis
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-8 (2021)
Abstract Background The Sequence Alignment/Map Format Specification (SAM) is one of the most widely adopted file formats in bioinformatics and many researchers use it daily. Several tools, including most high-throughput sequencing read aligners, use
Externí odkaz:
https://doaj.org/article/d4767d7134764e05acf5d8d02483bd95
Autor:
Tadashi Nakaya, Manolis Maragkakis
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Amyotrophic Lateral Sclerosis (ALS) is a lethal neurodegenerative disorder that primarily affects motor neurons. Dominant mutations in the RNA binding protein Fused in Sarcoma (FUS) have been identified as causative factors of ALS. Mutation,
Externí odkaz:
https://doaj.org/article/cb8569e4b09147fbb1c3b6d12bdc69e5
Autor:
Fadia Ibrahim, Manolis Maragkakis, Panagiotis Alexiou, Margaret A. Maronski, Marc A. Dichter, Zissimos Mourelatos
Publikováno v:
Cell Reports, Vol 3, Iss 2, Pp 301-308 (2013)
RNA binding proteins (RBPs) have emerged as major causative agents of amyotrophic lateral sclerosis (ALS). To investigate the function of TAF15, an RBP recently implicated in ALS, we explored its target RNA repertoire in normal human brain and mouse
Externí odkaz:
https://doaj.org/article/d2ddbbb3e27143e38b1a77afa32c6249
Autor:
Panagiotis Alexiou, Manolis Maragkakis, Giorgio L Papadopoulos, Victor A Simmosis, Lin Zhang, Artemis G Hatzigeorgiou
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9171 (2010)
BACKGROUND: High-throughput gene expression experiments are widely used to identify the role of genes involved in biological conditions of interest. MicroRNAs (miRNA) are regulatory molecules that have been functionally associated with several develo
Externí odkaz:
https://doaj.org/article/7259de18ccb44f9789c9c814f9b784ab
Autor:
Matthew J. Payea, Showkat A. Dar, Carlos Anerillas, Jennifer L. Martindale, Cedric Belair, Rachel Munk, Sulochan Malla, Jinshui Fan, Yulan Piao, Xiaoling Yang, Abid Rehman, Nirad Banskota, Kotb Abdelmohsen, Myriam Gorospe, Manolis Maragkakis
Senescence is a state of indefinite cell cycle arrest associated with aging, cancer, and age-related diseases. Here, using label-based mass spectrometry, ribosome profiling and nanopore direct RNA sequencing, we explore the coordinated interaction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eec71b1d961b5eaec8e316241049089
https://doi.org/10.1101/2023.04.12.536613
https://doi.org/10.1101/2023.04.12.536613
Autor:
James R. Occean, Na Yang, Yan Sun, Marshall S. Dawkins, Rachel Munk, Cedric Belair, Showkat Dar, Carlos Anerillas, Lin Wang, Changyou Shi, Christopher Dunn, Michel Bernier, Nathan L. Price, Julie S. Kim, Chang-Yi Cui, Jinshui Fan, Moitrayee Bhattacharyya, Supriyo De, Manolis Maragkakis, Rafael deCabo, Simone Sidoli, Payel Sen
Publikováno v:
bioRxiv
DNA hydroxymethylation (5hmC) is the most abundant oxidative derivative of DNA methylation (5mC) and is typically enriched at enhancers and gene bodies of transcriptionally active and tissue-specific genes. Although aberrant genomic 5hmC has been imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e7cbcf521a134df304647a81cc628d
https://doi.org/10.1101/2023.02.15.528714
https://doi.org/10.1101/2023.02.15.528714
Autor:
Sahba Seddighi, Yue A. Qi, Anna-Leigh Brown, Oscar G. Wilkins, Colleen Bereda, Cedric Belair, Yongjie Zhang, Mercedes Prudencio, Matthew J Keuss, Aditya Khandeshi, Sarah Pickles, Sarah E. Hill, James Hawrot, Daniel M. Ramos, Hebao Yuan, Jessica Roberts, Erika Kelmer Sacramento, Syed I. Shah, Mike A. Nalls, Jenn Colon-Mercado, Joel F. Reyes, Veronica H. Ryan, Matthew P. Nelson, Casey Cook, Ziyi Li, Laurel Screven, Justin Y Kwan, Anantharaman Shantaraman, Lingyan Ping, Yuka Koike, Björn Oskarsson, Nathan Staff, Duc M. Duong, Aisha Ahmed, Maria Secrier, Jerneg Ule, Steven Jacobson, Jonathan Rohrer, Andrea Malaspina, Jonathan D. Glass, Alessandro Ori, Nicholas T. Seyfried, Manolis Maragkakis, Leonard Petrucelli, Pietro Fratta, Michael E. Ward
Publikováno v:
bioRxiv
Functional loss of TDP-43, an RNA-binding protein genetically and pathologically linked to ALS and FTD, leads to inclusion of cryptic exons in hundreds of transcripts during disease. Cryptic exons can promote degradation of affected transcripts, dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52de4bfdb559430326ffc82718aa6b2a
https://europepmc.org/articles/PMC9900763/
https://europepmc.org/articles/PMC9900763/
Autor:
Yongjuan Guan, Hongyan Gao, N. Adrian Leu, Anastassios Vourekas, Panagiotis Alexiou, Manolis Maragkakis, Zissimos Mourelatos, Guanxiang Liang, P. Jeremy Wang
Transposable elements constitute nearly half of the mammalian genome and play important roles in genome evolution. While a multitude of both transcriptional and post-transcriptional mechanisms exist to silence transposable elements, control of transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ff29b24985259c02f24d709842fbd04
https://doi.org/10.1101/2022.12.13.520206
https://doi.org/10.1101/2022.12.13.520206