Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Manolis A. Fousteris"'
Autor:
Dionysios-Panagiotis Kintos, Konstantinos Salagiannis, Vasiliki Vazoura, Theresa Wittrien, Athanasios Papakyriakou, Sotiris S. Nikolaropoulos, Soenke Behrends, Stavros Topouzis, Manolis A. Fousteris
Publikováno v:
Heliyon, Vol 8, Iss 11, Pp e11438- (2022)
Herein, we present the structure-based design, synthesis and biological evaluation of novel mono- and di-carboxylic 3,4-dihydroquinoxalin-2(1H)-one derivatives as potential heme-independent activators of soluble guanylate cyclase (sGC). Docking calcu
Externí odkaz:
https://doaj.org/article/20fef75d9d9940de9efad9c71546b047
Publikováno v:
Bioorganic chemistry. 128
Prostate cancer (PCa) remains a serious type of cancer for men worldwide. The majority of new PCa cases are associated with androgen receptor (AR) hyperactivity. Various AR-targeting molecules that suppress its activity have been discovered. In this
Autor:
Sotiris S. Nikolaropoulos, Marina Bantzi, Manolis A. Fousteris, Aybike Yektaoglu, Athanassios Giannis, Aggeliki Roumana, Dimanthi Pliatsika
Publikováno v:
European Journal of Organic Chemistry. 2018:4147-4160
Autor:
Manolis A. Fousteris, Sotiris S. Nikolaropoulos, Ean-Jeong Seo, Antonios S. Letis, Thomas Efferth, Athanassios Giannis
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:3357-3367
A series of new artemisinin-derived hybrids which incorporate cholic acid moieties have been synthesized and evaluated for their antileukemic activity against sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 cells. The new hybrids 20-28 showed
Autor:
Marina Bantzi, Lothar Hennig, Manolis A. Fousteris, Athanassios Giannis, Sotiris S. Nikolaropoulos, Vassiliki Psarra
Publikováno v:
Tetrahedron. 72:2376-2385
The design and synthesis of small tetracyclic heterocycles which bear two new regioisomeric 2-carboxyethyl-1H-pyrrole-annulated indoloazepinone scaffolds is described. An azepinone motif, which is inherent in the structures of many well studied prote
Autor:
Manolis A. Fousteris, Vasileios Megalooikonomou, Maria Hatziapostolou, Margarita Lamprou, Evangelia Papadimitriou, Evgenia Lampropoulou, Marina Koutsioumpa, Efrosini Choleva, Christos Polytarchou, Angeliki Skoura, Ioanna Logoviti, Spyros S. Skandalis, S.S. Nikolaropoulos, Ulf Hellman
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports
Scientific Reports
Pleiotrophin (PTN) stimulates endothelial cell migration through binding to receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) and ανβ3 integrin. Screening for proteins that interact with RPTPβ/ζ and potentially regulate PTN signaling,
Autor:
Manolis A. Fousteris, C. Mourelatos, Th. Lialiaris, George Pairas, S.S. Nikolaropoulos, D. Lykidis, Dionysios Mourelatos, Maria Argyraki, S. Fidani
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 766:42-45
We studied the effects of three newly synthesized steroidal derivatives of nitrogen mustards, alone or in combination with caffeine, on sister chromatid exchange (SCE) frequencies and on human lymphocyte proliferation kinetics. The agents have as alk
Autor:
Anna I. Koutsourea, Georgios N. Pairas, Manolis A. Fousteris, Ioanna C. Papaconstantinou, Athanasios D. Papageorgiou, Sotiris S. Nikolaropoulos
Publikováno v:
Anti-Cancer Drugs. 24:52-65
On the basis of the results of in-silico predictions and in an effort to extend our structure-activity relationship studies, the aromatic nitrogen mustard 2-[4-N,N-bis(2-chloroethyl) amino-phenyl]butanoic acid (2-PHE-BU) was synthesized and conjugate
Publikováno v:
hc. 18:169-179
Synthetic efforts towards new tetracyclic heterocycles bearing the pyrrolo[2′,3′:5,6]azepino[4,3-b]indol-4(11H)-one core are described. Synthesized tetracyclic compounds are the first analogs, structurally related to protein kinase inhibitors pau
Autor:
Dimitra Kareli, E. Dafa, Manolis A. Fousteris, George Pairas, Th. Lialiaris, Maria Argyraki, C. Mourelatos, Anna I. Koutsourea, S.S. Nikolaropoulos, I. Papakonstantinou
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 746:1-6
New compounds with potential antitumour activity were synthesised by combining nitrogen mustard with the steroidal skeleton, in an effort to improve specificity and at the same time reduce systemic toxicity. The steroidal part is aimed to serve as a