Výsledky vyhledávání - "Manojkumar A Puthenveedu"

Akademický článek

Conformational specificity of opioid receptors is determined by subcellular location irrespective of agonist

Autor: Stephanie E Crilly, Wooree Ko, Zara Y Weinberg, Manojkumar A Puthenveedu

Publikováno v: eLife, Vol 10 (2021)

The prevailing model for the variety in drug responses is that different drugs stabilize distinct active states of their G protein-coupled receptor (GPCR) targets, allowing coupling to different effectors. However, whether the same ligand generates d

Externí odkaz: https://doaj.org/article/66e06d8ec03a497d93f59280819150ea

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Akademický článek

Compartment-specific opioid receptor signaling is selectively modulated by different dynorphin peptides

Autor: Jennifer M Kunselman, Achla Gupta, Ivone Gomes, Lakshmi A Devi, Manojkumar A Puthenveedu

Publikováno v: eLife, Vol 10 (2021)

Many signal transduction systems have an apparent redundancy built into them, where multiple physiological agonists activate the same receptors. Whether this is true redundancy, or whether this provides an as-yet unrecognized specificity in downstrea

Externí odkaz: https://doaj.org/article/3d0d23663e8e4701b7daae6d9fe62f91

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Akademický článek

PIP5KIβ selectively modulates apical endocytosis in polarized renal epithelial cells.

Autor: Christina M Szalinski, Christopher J Guerriero, Wily G Ruiz, Brianne E Docter, Youssef Rbaibi, Núria M Pastor-Soler, Gerard Apodaca, Manojkumar A Puthenveedu, Ora A Weisz

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e53790 (2013)

Localized synthesis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2)] at clathrin coated pits (CCPs) is crucial for the recruitment of adaptors and other components of the internalization machinery, as well as for regulating actin dynamics d

Externí odkaz: https://doaj.org/article/875ca782e48b4344a81acae0687ed123

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Vesicle-associated membrane protein 2 is a cargo-selective v-SNARE for a subset of GPCRs

Autor: Hao Chen, Zara Y. Weinberg, G. Aditya Kumar, Manojkumar A. Puthenveedu

Publikováno v: Journal of Cell Biology. 222

Vesicle fusion at the plasma membrane is critical for releasing hormones and neurotransmitters and for delivering the cognate G protein–coupled receptors (GPCRs) to the cell surface. The SNARE fusion machinery that releases neurotransmitters has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b65fe1ee51a1ef7ed29ab88bf16034e9
https://doi.org/10.1083/jcb.202207070

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