Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Manoj Varshney"'
Autor:
Manoj Varshney
Publikováno v:
International Journal for Research in Applied Science and Engineering Technology. :1235-1244
Thromboelastographic and pharmacokinetic profiles of micro- and macro-emulsions of propofol in swine
Autor:
Hartmut Derendorf, Donn M. Dennis, Dinesh O. Shah, Nikolaus Gravenstein, Manoj Varshney, Timothy E. Morey, Jerome H. Modell, Jorge E. Garcia, Michael Bewernitz
Publikováno v:
Biopharmaceutics & Drug Disposition. 31:269-277
Purpose. Compared with traditional macroemulsion propofol formulations currently in clinical use, microemulsion formulations of this common intravenous anesthetic may offer advantages. The pharmacokinetics and coagulation effects as assessed by throm
Autor:
Surender Rajasekaran, Jason A. Flint, Donn M. Dennis, Dinesh O. Shah, Manoj Varshney, Timothy E. Morey
Publikováno v:
Nano letters. 4(4)
Because of its ability to create structures of nanoscale dimension with large aggregate particle surface area-to-volume ratios, nanotechnology offers new opportunities to treat drug poisonings. Emulsion-based nanoparticles (diameter: 118.4 nm) extrac
Autor:
Jason A. Flint, Timothy E. Morey, Donn M. Dennis, Manoj Varshney, Aleksa V. Jovanovic, Randolph S. Duran
Publikováno v:
Biomacromolecules. 7:945-949
In this article we present the synthesis of oil core silica shell nanocapsules with different shell thicknesses. The surface of the nanocapsules was modified with polyethyleoxide (PEO) and succinic anhydride. Two biomedical tests were then used to st
Autor:
F. Kayser Enneking, Donn M. Dennis, Timothy E. Morey, Elizabeth M. Renehan, Manoj Varshney, Richard E. Partch
Publikováno v:
Regional Anesthesia and Pain Medicine. 30:380-384
Publikováno v:
Colloids and Surfaces B: Biointerfaces. 41:25-32
In vitro transdermal permeation of 5-fluorouracil (antineoplastic), a hydrophilic drug encapsulated in AOT/water/isopropylmyristate water-in-oil microemulsions (MEs), were studied using a modified Keshary and Chien diffusion cell. AOT (aerosol-OT or
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 31:381-400
Nanoparticles (NPs) may be capable of reversing the toxic effects of drug overdoses in humans by adsorbing/absorbing drug molecules. This paper develops a model to include the kinetic effects of treating drug overdoses by NPs. Depending on the size a
Autor:
Dinesh O. Shah, Christoph N. Seubert, David G. Bjoraker, Timothy E. Morey, Donn M. Dennis, W. Brit Smith, Jason A. Flint, Manoj Varshney
Publikováno v:
Journal of Nanoparticle Research. 6:159-170
Background: Although microemulsion-based nanoparticles (MEs) may be useful for drug delivery or scavenging, these benefits must be balanced against potential nanotoxicological effects in biological tissue (bio-nano interface). We investigated the act
Autor:
Aleksa V. Jovanovic, Manoj Varshney, Donn M. Dennis, Royale S. Underhill, Dinesh O. Shah, Randolph S. Duran, and Timothy E. Morey, Stephen R. Carino
Publikováno v:
Chemistry of Materials. 14:4919-4925
Oil-filled nanocapsules were synthesized using the oil droplets of an O/W microemulsion as templates. A polysiloxane/silicate shell was formed at the surface of the oil droplet by cross-linking n-o...
Publikováno v:
Colloids and Surfaces B: Biointerfaces. 13:1-11
In vitro and in vivo transdermal permeation of glyceryl trinitrate encapsulated in the AOT normal micellar and reverse micellar systems were studied. The effects of water and aerosol-OT (AOT) concentrations to the carrier property of AOT micellar sys