Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Manoj T, Duraisingh"'
Autor:
Jingjing Lou, Yasaman Rezvani, Argenis Arriojas, Yihan Wu, Nachiket Shankar, David Degras, Caroline D. Keroack, Manoj T. Duraisingh, Kourosh Zarringhalam, Marc-Jan Gubbels
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Sequential lytic cycles driven by cascading transcriptional waves underlie pathogenesis in the apicomplexan parasite Toxoplasma gondii. This parasite’s unique division by internal budding, short cell cycle, and jumbled up classically defin
Externí odkaz:
https://doaj.org/article/a813754912e246219b7e973dd960c406
Autor:
Jiahong Li, Gerald J. Shami, Benjamin Liffner, Ellie Cho, Filip Braet, Manoj T. Duraisingh, Sabrina Absalon, Matthew W. A. Dixon, Leann Tilley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Plasmodium falciparum is the causative agent of malaria and remains a pathogen of global importance. Asexual blood stage replication, via a process called schizogony, is an important target for the development of new antimalarials. Here we u
Externí odkaz:
https://doaj.org/article/16e0381c3af445ca9a233aecf586db04
Autor:
Christopher J. Day, Paola Favuzza, Sabrina Bielfeld, Thomas Haselhorst, Leonie Seefeldt, Julia Hauser, Lucy K. Shewell, Christian Flueck, Jessica Poole, Freda E.-C. Jen, Anja Schäfer, Jean-Pierre Dangy, Tim-W. Gilberger, Camila Tenorio França, Manoj T. Duraisingh, Marco Tamborrini, Nicolas M.B. Brancucci, Christof Grüring, Michael Filarsky, Michael P. Jennings, Gerd Pluschke
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114012- (2024)
Summary: Plasmodium falciparum is a human-adapted apicomplexan parasite that causes the most dangerous form of malaria. P. falciparum cysteine-rich protective antigen (PfCyRPA) is an invasion complex protein essential for erythrocyte invasion. The pr
Externí odkaz:
https://doaj.org/article/b1552435879b4808a30ae832a3d6786d
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
BackgroundChemotherapies for malaria and babesiosis frequently succumb to the emergence of pathogen-related drug-resistance. Host-targeted therapies are thought to be less susceptible to resistance but are seldom considered for treatment of these dis
Externí odkaz:
https://doaj.org/article/874d85924e1b42a9aa1677a88f256ce2
Autor:
Rashmi Dash, Kristen M. Skillman, Ligia Pereira, Anjali Mascarenhas, Sheena Dass, Jayashri Walke, Anvily Almeida, Mezia Fernandes, Edwin Gomes, John White, Laura Chery-Karschney, Anar Khandeparkar, Pradipsinh K. Rathod, Manoj T. Duraisingh, Usheer Kanjee
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-10 (2023)
Abstract Background Plasmodium vivax is the second most prevalent cause of malaria yet remains challenging to study due to the lack of a continuous in vitro culture system, highlighting the need to establish a biobank of clinical isolates with multip
Externí odkaz:
https://doaj.org/article/bb5a53c8e3014dd7b277b32f277d6af7
Autor:
Padmapriya Sekar, Sumati Rajagopalan, Estela Shabani, Usheer Kanjee, Marc A Schureck, Gunjan Arora, Mary E Peterson, Boubacar Traore, Peter D Crompton, Manoj T Duraisingh, Sanjay A Desai, Eric O Long
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011585 (2023)
Natural killer (NK) cells lyse virus-infected cells and transformed cells through polarized delivery of lytic effector molecules into target cells. We have shown that NK cells lyse Plasmodium falciparum-infected red blood cells (iRBC) via antibody-de
Externí odkaz:
https://doaj.org/article/aff072e252f94230992a43f271b45acd
Autor:
Erik J. Scully, Weimin Liu, Yingying Li, Jean-Bosco N. Ndjango, Martine Peeters, Shadrack Kamenya, Anne E. Pusey, Elizabeth V. Lonsdorf, Crickette M. Sanz, David B. Morgan, Alex K. Piel, Fiona A. Stewart, Mary K. Gonder, Nicole Simmons, Caroline Asiimwe, Klaus Zuberbühler, Kathelijne Koops, Colin A. Chapman, Rebecca Chancellor, Aaron Rundus, Michael A. Huffman, Nathan D. Wolfe, Manoj T. Duraisingh, Beatrice H. Hahn, Richard W. Wrangham
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Chimpanzees are known to suffer from malaria parasitism. Here, the prevalence and epidemiology of several malaria parasites is examined in a wild chimpanzee population.
Externí odkaz:
https://doaj.org/article/81b818d48eff4996a28da97a100a59af
Publikováno v:
PLoS Biology, Vol 21, Iss 1, p e3001997 (2023)
Twenty years ago, the first transcriptome of the intraerythrocytic developmental cycle of the malaria parasite Plasmodium falciparum was published in PLOS Biology. Since then, transcriptomics studies have transformed the study of parasite biology.
Externí odkaz:
https://doaj.org/article/3f4e1f3cd21741d3826e60058f21de23
Autor:
Anna Olivieri, Rebecca S. Lee, Federica Fratini, Cyrianne Keutcha, Mudit Chaand, Valentina Mangano, Francesco Celani, Stefania Mochi, Cecilia Birago, Silvio Paone, Felicia Grasso, Valentina Tirelli, Mario Falchi, Estela Shabani, Stefania Bertoncini, Bienvenu Sodiomon Sirima, Elisabetta Pizzi, David Modiano, Manoj T. Duraisingh, Marta Ponzi
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Olivieri et al. exploit floating properties of microdomain-associated proteins to investigate host proteins important for Plasmodium falciparum erythrocyte invasion. Using proteomic and bioinformatic approaches, they analyze clusters of protein abund
Externí odkaz:
https://doaj.org/article/eb05db52ac9b4a6f8a32f15f23b8ee8e
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 16, Iss , Pp 23-37 (2021)
Plasmodium vivax is the most geographically widespread cause of human malaria and is responsible for the majority of cases outside of the African continent. While great progress has been made towards eliminating human malaria, drug resistant parasite
Externí odkaz:
https://doaj.org/article/564ec85389e24225b05f98171a34cb46