Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Manoj S. Chiney"'
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 395-404 (2021)
Antibody drug conjugates (ADCs) provide targeted delivery of cytotoxic agents directly inside tumor cells. However, many ADCs targeting solid tumors have exhibited limited clinical efficacy, in part, due to insufficient penetration within tumors. To
Externí odkaz:
https://doaj.org/article/312cea22690440858ae4609ed1a38617
Autor:
Dwaipayan Mukherjee, Manoj S. Chiney, Xi Shao, Tzuchi R. Ju, Mohamad Shebley, Patrick Marroum
Publikováno v:
Biopharmaceuticsdrug disposition. 43(3)
The aim of this analysis was to use a physiologically based pharmacokinetic (PBPK) model to predict the impact of changes in dissolution rates on elagolix exposures and define clinically relevant acceptance criteria for dissolution. Varying in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae47bc3570976543769d757e4916686
https://pubmed.ncbi.nlm.nih.gov/35405765
https://pubmed.ncbi.nlm.nih.gov/35405765
Publikováno v:
British journal of clinical pharmacology. 72(1)
It is well established that oxidative and conjugative enzyme activity differs between obese and healthy-weight adults. However, the effect of obesity on drug metabolism in children has not been studied extensively. This study examined whether obese a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c40f0280b1b8889c3812f8b45c7a2d6
https://pubmed.ncbi.nlm.nih.gov/21382071
https://pubmed.ncbi.nlm.nih.gov/21382071