Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Manoj Reddy Medapati"'
Autor:
Nisha Singh, Ben Ulmer, Manoj Reddy Medapati, Christine Zhang, Robert J. Schroth, Saeid Ghavami, Prashen Chelikani
Publikováno v:
Cells, Vol 13, Iss 6, p 531 (2024)
Macroautophagy (hereafter autophagy) is a lysosomal degradation pathway that functions in nutrient recycling and as a mechanism of innate immunity. Previously, we reported a novel host–bacteria interaction between cariogenic S. mutans and bitter ta
Externí odkaz:
https://doaj.org/article/a9be027d335140eb9c1f28c360e96b6a
Autor:
Anjali Y. Bhagirath, Vikram Bhatia, Manoj Reddy Medapati, Nisha Singh, Martha Hinton, Prashen Chelikani, Shyamala Dakshinamurti
Publikováno v:
FASEB BioAdvances, Vol 4, Iss 3, Pp 180-196 (2022)
Abstract Activation of adenylyl cyclases (ACs) by G‐protein Gαs catalyzes the production of cyclic adenosine monophosphate (cAMP), a key second messenger that regulates diverse physiological responses. There are 10 AC isoforms present in humans, w
Externí odkaz:
https://doaj.org/article/ef97d68348634414bdca5f9739cf406e
Autor:
Anjali Y. Bhagirath, Manoj Reddy Medapati, Vivianne Cruz de Jesus, Sneha Yadav, Martha Hinton, Shyamala Dakshinamurti, Devi Atukorallaya
Publikováno v:
Frontiers in Oral Health, Vol 2 (2021)
Pregnancy is a tightly regulated immunological state. Mild environmental perturbations can affect the developing fetus significantly. Infections can elicit severe immunological cascades in the mother's body as well as the developing fetus. Maternal i
Externí odkaz:
https://doaj.org/article/7c93665242cc4c228510e896b97f8586
Autor:
Sabine Hombach‐Klonisch, Forouh Kalantari, Manoj Reddy Medapati, Suchitra Natarajan, Sai Nivedita Krishnan, Aditya Kumar‐Kanojia, Thatchawan Thanasupawat, Farhana Begum, Fred Y. Xu, Grant M. Hatch, Marek Los, Thomas Klonisch
Publikováno v:
Molecular Oncology, Vol 13, Iss 2, Pp 153-170 (2019)
Poly(ADP‐ribose) polymerase 1 inhibitors alone or in combination with DNA damaging agents are promising clinical drugs in the treatment of cancer. However, there is a need to understand the molecular mechanisms of resistance to PARP1 inhibitors. Ex
Externí odkaz:
https://doaj.org/article/6d09dbc596134a22a127ea18afe858e3
Autor:
Sabine eHombach-Klonisch, Suchitra eNatarajan, Thatchawan eThanasupawat, Manoj Reddy Medapati, Alok ePathak, Saeid eGhavami, Thomas eKlonisch
Publikováno v:
Frontiers in Endocrinology, Vol 5 (2014)
Tissue invasion, metastasis and therapeutic resistance to anti-cancer treatments are common and main causes of death in cancer patients. Tumor cells mount complex and still poorly understood molecular defense mechanisms to counteract and evade oxygen
Externí odkaz:
https://doaj.org/article/94150268f463464691481b816318dce2
Autor:
Manoj Reddy Medapati, Rajinder P. Bhullar, Robert J Schroth, Prashen Chelikani, Kangmin Duan, Nisha Singh, Anjali Y. Bhagirath
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 18
International Journal of Molecular Sciences, Vol 22, Iss 9920, p 9920 (2021)
Volume 22
Issue 18
International Journal of Molecular Sciences, Vol 22, Iss 9920, p 9920 (2021)
Bitter-taste receptors (T2Rs) have emerged as key players in host–pathogen interactions and important modulators of oral innate immunity. Previously, we reported that T2R14 is expressed in gingival epithelial cells (GECs) and interacts with compete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74162ed38d0b279803c76c6dd8040944
Autor:
Anjali Y. Bhagirath, Manoj Reddy Medapati, Prashen Chelikani, Vikram Bhatia, Nisha Singh, Shyamala Dakshinamurti, Martha Hinton
Publikováno v:
FASEB bioAdvances. 4(3)
Activation of adenylyl cyclases (ACs) by G-protein Gαs catalyzes the production of cyclic adenosine monophosphate (cAMP), a key second messenger that regulates diverse physiological responses. There are 10 AC isoforms present in humans, with AC5 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44855115896e63b3cc971d237d740e4a
https://pubmed.ncbi.nlm.nih.gov/35664968
https://pubmed.ncbi.nlm.nih.gov/35664968
Publikováno v:
Handbook of experimental pharmacology. 275
Bitter taste receptors (T2Rs) belong to the G protein-coupled receptor superfamily. Humans express 25 T2Rs that are known to detect several bitter compounds including bacterial quorum sensing molecules (QSM). Primarily found to be key receptors for b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1caf27ba2233b559a7ffcd5a108cb63e
https://pubmed.ncbi.nlm.nih.gov/33580389
https://pubmed.ncbi.nlm.nih.gov/33580389
Autor:
Manoj Reddy Medapati, Eraldo L. Batista, Barbara Triggs-Raine, Prashen Chelikani, Kangmin Duan, Nisha Singh, Anjali Y. Bhagirath
Publikováno v:
The FASEB Journal. 35
Host-pathogen interactions play an important role in defining the outcome of a disease. Recent studies have shown that the bacterial quorum sensing molecules (QSM) can interact with host cell membrane proteins, mainly G protein-coupled receptors (GPC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9847e088615b0f4bb9361891aabf027
https://doi.org/10.1096/fj.202000208r
https://doi.org/10.1096/fj.202000208r
Autor:
Anjali Y. Bhagirath, Vivianne Cruz de Jesus, Manoj Reddy Medapati, Prashen Chelikani, Nisha Singh
Taste is an important determinant for both the food industry and therapeutics. The mechanism of taste perception is complex and depends on genetic and non-genetic factors. Recent years have seen advances in our understanding of structural and functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec59ac7fb14e1c87eaa9f8068f7f72a6
https://doi.org/10.1039/9781839163425-00460
https://doi.org/10.1039/9781839163425-00460
