Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Manoj P. Menon"'
Publikováno v:
JCO Global Oncology, Vol , Iss 7, Pp 127-132 (2021)
The Uganda Cancer Institute, the sole national comprehensive cancer center in Uganda, has a long and rich history of clinical investigation and locally relevant cancer research. Given the increasing burden of breast cancer in Uganda and elsewhere in
Externí odkaz:
https://doaj.org/article/b80a977b3c944ed5bfa1d7458c11158e
Autor:
Manoj P. Menon, Anna Coghill, Innocent O. Mutyaba, Warren T. Phipps, Fred M. Okuku, John M. Harlan, Jackson Orem, Corey Casper
Publikováno v:
Journal of Global Oncology, Vol 4, Pp 1-9 (2017)
Purpose: The HIV epidemic has contributed to the increasing incidence of cancer in sub-Saharan Africa, where most patients with cancer present at an advanced stage. However, improved access to HIV care and treatment centers in sub-Saharan Africa may
Externí odkaz:
https://doaj.org/article/d14a65a8b8844b1e874b2edcf9696f36
Autor:
Chanchal Chauhan, Andreas Kraemer, Stefan Knapp, Mark Windheim, Alexey Kotlyarov, Manoj B. Menon, Matthias Gaestel
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Receptor-interacting protein kinases (RIPK)-1 and -3 play crucial roles in cell fate decisions and are regulated by multiple checkpoint controls. Previous studies have identified IKK1/2- and p38/MK2-dependent checkpoints that phosphorylate R
Externí odkaz:
https://doaj.org/article/214dfff180f143c98a84560bdae9641d
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Autophagy plays an important role in recognizing and protecting cells from invading intracellular pathogens such as Salmonella. In this work, we investigated the role of p38MAPK/MK2 in modulating the host cell susceptibility to Salmonella infection.
Externí odkaz:
https://doaj.org/article/79d6627d802a45bf991f59e8a0574ba8
Autor:
Chanchal Chauhan, Ana Martinez-Val, Rainer Niedenthal, Jesper Velgaard Olsen, Alexey Kotlyarov, Simon Bekker-Jensen, Matthias Gaestel, Manoj B. Menon
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract The TNF receptor-interacting protein kinases (RIPK)-1 and 3 are regulators of extrinsic cell death response pathways, where RIPK1 makes the cell survival or death decisions by associating with distinct complexes mediating survival signaling,
Externí odkaz:
https://doaj.org/article/842e471da4e14b86910bc06814c7448e
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/b3b43b4448fc4d8b97baa2cdf5c1987e
Autor:
Abdul Alim Al-Bari, Yuko Ito, Paul G. Thomes, Manoj B. Menon, Marina García-Macia, Raouf Fadel, Alfreda Stadlin, Nicholas Peake, MoezAlIslam Ezzat Faris, Nabil Eid, Daniel J. Klionsky
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Macroautophagy (hereafter referred to as autophagy), a highly conserved metabolic process, regulates cellular homeostasis by degrading dysfunctional cytosolic constituents and invading pathogens via the lysosomal system. In addition, autophagy select
Externí odkaz:
https://doaj.org/article/b1045026d0ce4ede987d00930c609213
Autor:
Shivaksh Ahluwalia, Belal Ahmad, Uzma Salim, Dipannita Ghosh, Vinay Kamuju, Arpita Ghosh, Khadija Dabeer, Manoj B. Menon, Perumal Vivekanandan
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Clinical and in vivo studies have demonstrated a role for hepatitis B virus (HBV)-encoded HBsAg (hepatitis B surface antigen) in HBV-related hepatocellular carcinoma (HCC); however, the underlying mechanisms remain largely unknown. Here, we
Externí odkaz:
https://doaj.org/article/c39bf431975b45c1beb6b42af391b091
Autor:
Manoj B. Menon, Tatiana Yakovleva, Natalia Ronkina, Abdulhadi Suwandi, Ivan Odak, Sonam Dhamija, Inga Sandrock, Florian Hansmann, Wolfgang Baumgärtner, Reinhold Förster, Alexey Kotlyarov, Matthias Gaestel
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
By crossing septin7-floxed mice with Lyz2-Cre mice carrying the Cre recombinase inserted in the Lysozyme-M (Lyz2) gene locus we aimed the specific deletion of septin7 in myeloid cells, such as monocytes, macrophages and granulocytes. Septin7flox/flox
Externí odkaz:
https://doaj.org/article/886ae178359b4833b25d02f06472272b
Autor:
Sanket Mukherjee, Akhil Kumar, Jasmine Samal, Ekta Gupta, Perumal Vivekanandan, Manoj B. Menon
Publikováno v:
Pathogens, Vol 12, Iss 1, p 43 (2022)
Hepatitis C virus (HCV) is a bloodborne pathogen that can cause chronic liver disease and hepatocellular carcinoma. The loss of CpGs from virus genomes allows escape from restriction by the host zinc-finger antiviral protein (ZAP). The evolution of H
Externí odkaz:
https://doaj.org/article/c1583a5626e8423ca8b648bcd2bebd89