Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Manoj M Lalu"'
Autor:
Brian Hutton, Dean A Fergusson, Manoj M Lalu, Daniel I McIsaac, Guillaume Martel, Alexis F Turgeon, Husein Moloo, Mélanie Bérubé, Ian Gilron, Patricia Poulin, Stuart Nicholls, Jason McVicar, Maxime Le, Michael Verret, Fiona Zivkovic, Megan Graham, Allison Geist, Helena Daudt, John Bao Phuc Le
Publikováno v:
BMJ Open, Vol 14, Iss 2 (2024)
Introduction Dexmedetomidine is a promising pharmaceutical strategy to minimise opioid use during surgery. Despite its growing use, it is uncertain whether dexmedetomidine can improve patient-centred outcomes such as quality of recovery and pain.Meth
Externí odkaz:
https://doaj.org/article/875156ee7f724004a8004077ca33d8e7
Autor:
Jenny L Olson, Gisell Castillo, Amelia Palumbo, Megan Harrison, Ruth Singleton, Manoj M Lalu, Dean A Fergusson, Alain Stintzi, David R Mack, Justin Presseau
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0292709 (2024)
BackgroundProcess evaluations conducted alongside clinical trials can improve understanding of treatment fidelity and provide contextual knowledge to aide interpretations of trial outcomes. We adopted a multiple-goals perspective to investigate treat
Externí odkaz:
https://doaj.org/article/e73432dbc46e4a8289830370388bef69
Autor:
Matthew S Jeffers, Aileen MacLellan, Marc T Avey, Julia Ml Menon, Janet Sunohara-Neilson, Dean A Fergusson, Manoj M Lalu
Publikováno v:
PLoS Biology, Vol 21, Iss 10, p e3002293 (2023)
Protocol registration is required in clinical trials. Registration of animal studies could improve research transparency and reduce redundancy, yet uptake has been minimal. Integrating study registration into institutional approval of animal use prot
Externí odkaz:
https://doaj.org/article/c6a6d8ef56a44e72907d0281a57d838f
Autor:
Kelly D Cobey, Christophe A Fehlmann, Marina Christ Franco, Ana Patricia Ayala, Lindsey Sikora, Danielle B Rice, Chenchen Xu, John PA Ioannidis, Manoj M Lalu, Alixe Ménard, Andrew Neitzel, Bea Nguyen, Nino Tsertsvadze, David Moher
Publikováno v:
eLife, Vol 12 (2023)
Background: Reproducibility is a central tenant of research. We aimed to synthesize the literature on reproducibility and describe its epidemiological characteristics, including how reproducibility is defined and assessed. We also aimed to determine
Externí odkaz:
https://doaj.org/article/6a614befd9734eb4a4ebf90bd6a3a343
Autor:
Victoria T Hunniford, Agnes Grudniewicz, Dean A Fergusson, Joshua Montroy, Emma Grigor, Casey Lansdell, Manoj M Lalu, On behalf of The Canadian Critical Care Translational Biology Group
Publikováno v:
eLife, Vol 12 (2023)
Background: Multicentric approaches are widely used in clinical trials to assess the generalizability of findings, however, they are novel in laboratory-based experimentation. It is unclear how multilaboratory studies may differ in conduct and result
Externí odkaz:
https://doaj.org/article/c3bacf29ec004c61ba79555030c592f1
Autor:
Brian Hutton, Dean A Fergusson, Manoj M Lalu, Daniel I McIsaac, Guillaume Martel, Alexis F Turgeon, Husein Moloo, Mélanie Bérubé, Ian Gilron, Patricia Poulin, Jason McVicar, Maxime Le, Michael Verret, Nhat Hung Lam, Stuart G Nicholls, Myriam Hamtiaux, Sriyathavan Srichandramohan, Abdulaziz Al-Mazidi, Nicholas A Fergusson, Fiona Zivkovic, Megan Graham, Allison Geist, Helena Daudt
Publikováno v:
BMJ Open, Vol 13, Iss 3 (2023)
Introduction For close to a century opioid administration has been a standard of care to complement anaesthesia during surgery. Considering the worldwide opioid epidemic, this practice is now being challenged and there is a growing use of systemic ph
Externí odkaz:
https://doaj.org/article/67a477a6e80e4cf39945335003cc559a
Autor:
Manoj M Lalu, Justin Presseau, Madison K Foster, Victoria T Hunniford, Kelly D Cobey, Jamie C Brehaut, Carolina Ilkow, Joshua Montroy, Analyssa Cardenas, Ayni Sharif, Matthew S Jeffers, Dean A Fergusson
Publikováno v:
PLoS Biology, Vol 21, Iss 1, p e3001932 (2023)
Use of rigorous study design methods and transparent reporting in publications are 2 key strategies proposed to improve the reproducibility of preclinical research. Despite promotion of these practices by funders and journals, assessments suggest upt
Externí odkaz:
https://doaj.org/article/7c1b9dca302b43ebafa4f4159c7a047f
Autor:
Dean A Fergusson, Alan Forster, Gregg Nelson, Monica Taljaard, Jayna Holroyd-Leduc, Manoj M Lalu, John Muscedere, Duminda Wijeysundera, Daniel I McIsaac, Sylvain Boet, Kednapa Thavorn, Michael McMullen, Tarit Saha, Eric Jacobsohn, Tien Le, Husein Moloo, Allen Huang, Gary Dobson, Grace Ma, Stephanie Johnson, Colin McCartney, Elijah Dixon, Emily Hladkowicz, Sylvain Gagne, Julie Nantel, Barbara Power, Chelsia Gillis, Rodney Breau, Irfan Dhalla, Susan Lee, Rachel Khadaroo, Amanda Meliambro, Daniel Trottier, Keely Barnes, Laura Boland, Karina Branje, Gregory L. Bryson, Rosaleen Chun, Antoine Eskander, Hannah Frazer, Joanne Hutton, John Joanisse, Ana Johnson, Luke T. Lavallee, Cameron Love, Ronald Moore, Thomas Mutter, Sudhir Nagpal, Celena Scheede-Bergdhal, Pablo Serrano, Laura Tamblyn-Watts, Carl van Walraven, Brittany Warren, Ilun Yang
Publikováno v:
BMJ Open, Vol 12, Iss 8 (2022)
Introduction Frailty is a strong predictor of adverse postoperative outcomes. Prehabilitation may improve outcomes after surgery for older people with frailty by addressing physical and physiologic deficits. The objective of this trial is to evaluate
Externí odkaz:
https://doaj.org/article/6d39c9b5aa754cb5a45f01e9fd67d633
Autor:
David Moher, Agnes Grudniewicz, Kelly D Cobey, Manoj M Lalu, Joshua Montroy, Gregory L Bryson, Christian Lehmann, Olivier Brandts-Longtin, Euan A Adie, Marc A Albert, Elham Almoli, Faris Almoli, Christophe Dony, Daniel Dunleavy, Rémy Lhoest, Mallory Pitts, Alicia Ricketts, Paul Thirion
Publikováno v:
BMJ Open, Vol 12, Iss 4 (2022)
Introduction Many predatory journals fail to follow best publication practices. Studies assessing the impact of predatory journals have focused on how these articles are cited in reputable academic journals. However, it is possible that research from
Externí odkaz:
https://doaj.org/article/ddee563746c242cd966798b5d0b7ede1
Autor:
Madison Foster, Dean A Fergusson, Terry Hawrysh, Justin Presseau, Natasha Kekre, Stuart Schwartz, Gisell Castillo, Sarah Asad, Grace Fox, Harold Atkins, Kednapa Thavorn, Joshua Montroy, Robert A Holt, Zarah Monfaredi, Manoj M Lalu
Publikováno v:
Research Involvement and Engagement, Vol 6, Iss 1, Pp 1-10 (2020)
Abstract Aim Though patient engagement in clinical research is growing, recent reports suggest few clinical trials report on such activities. To address this gap, we describe our approach to patient engagement in the development of a clinical trial p
Externí odkaz:
https://doaj.org/article/41291d56e02947a0aa68b46ceb1c3cfe