Výsledky vyhledávání - "Manoj Kumar Tikoo"

Determination of ZSTK474, a novel Pan PI3K inhibitor in mouse plasma by LC–MS/MS and its application to Pharmacokinetics

Autor: Priya Wazir, Parvinder Pal Singh, Vijayabhaskar, Thanusha Thatikonda, Manoj Kumar Tikoo, Ajay Prakash Gupta, Amit Kumar, Amarinder Singh, Surjeet Singh, Utpal Nandi, Gurdarshan Singh, Ram A. Vishwakarma

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 149:387-393

ZSTK474, a promising novel anticancer molecule derived from s-triazine, found to have antitumor activities against different cancer cell lines. However, neither LCMS method nor pharmacokinetics of ZSTK474 has been reported till now. A sensitive, simp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7bef845aa31eda218d711f2b14d1b1
https://doi.org/10.1016/j.jpba.2017.11.031

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Development and validation of a highly sensitive LC-ESI-MS/MS method for estimation of IIIM-MCD-211, a novel nitrofuranyl methyl piperazine derivative with potential activity against tuberculosis: Application to drug development

Autor: Priya Wazir, Manoj Kumar Tikoo, Anjna Sharma, Ram A. Vishwakarma, Parvinder Pal Singh, Asmita Magotra, Ajai Prakash Gupta, Utpal Nandi, Gurdarshan Singh, Shweta Sharma

Publikováno v: Journal of Chromatography B. 1060:200-206

In the present study, a simple, sensitive, specific and rapid liquid chromatography (LC) tandem mass spectrometry (MS/MS) method was developed and validated according to the Food and Drug Administration (FDA) guidelines for estimation of IIIM-MCD-211

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b6cdb3a77734b5a2786bc919fa6807
https://doi.org/10.1016/j.jchromb.2017.06.015

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Nitrofuranyl Methyl Piperazines as New Anti-TB Agents: Identification, Validation, Medicinal Chemistry, and PK Studies

Autor: Giriraj Singh, Inshad Ali Khan, Vikrant Singh Rajput, Gurunadham Munagala, Samsher Singh, Kushalava Reddy Yempalla, Sonali S. Bharate, Ram A. Vishwakarma, Asmita Magotra, Sunil Kumar, Manoj Kumar Tikoo, Parvinder Pal Singh

Publikováno v: ACS Medicinal Chemistry Letters. 6:1041-1046

Whole-cell screening of 20,000 drug-like small molecules led to the identification of nitrofuranyl methylpiperazines as potent anti-TB agents. In the present study, validation followed by medicinal chemistry has been used to explore the structure-act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626e802ba961b077a772d194fd6ae75a
https://doi.org/10.1021/acsmedchemlett.5b00141

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Re-Validation of New Develop Highly Sensitive, Simple LCMS/MS Method for the Estimation of Rohitukine and its Application in ADME/Pre-Clinical Pharmacokinetics

Autor: Utpal Nandi, Surjeet Singh, Pankaj Chibber, Gurdarshan Singh, Priya Wazir, Sumit G. Gandhi, Nitika Kapoor, Manoj Kumar Tikoo, Ram A. Vishwakarma, Amarinder Singh, Amit Kumar

Publikováno v: Mass Spectrometry & Purification Techniques.

The purpose of the research was to develop a simple, rapid, accurate, reproducible and sensitive liquid chromatography–tandem mass spectrometry (LC-MS/MS) method for determination of Rohitukine, a chromone alkaloid in plasma. The chromatographic se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::798d3817d6f2038b177c1d69b7053888
https://doi.org/10.4172/2469-9861.1000120

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Acute, sub-acute and general pharmacological evaluation of 5-(3,4-methylenedioxyphenyl)-4-ethyl-2E,4E-pentadienoic acid piperidide (SK-20): A novel drug bioavailability enhancer

Autor: Manoj Kumar Tikoo, Amarinder Singh, Dastagir Basheer Ahamad, Sheikh Rayees, Surinder Koul, Surjeet Singh, Rohit Sharma, Ishtiyaq Ahmad Najar, Gurdarshan Singh, Payare L. Sangwan, V. K. Gupta, Rakesh Kamal Johri, Subash Chander Sharma

Publikováno v: Environmental Toxicology and Pharmacology. 35:347-359

An efflux pump inhibitor, SK-20 (5-(3,4-methylenedioxyphenyle)-4 ethyl-2E,4E-pentadienoic acid piperidide), was assessed for its toxicity at three different pharmacological profiles: acute, sub-acute and general pharmacology with pharmacokinetics. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddb7afa3fcf4d8c000d7c76c15a0a7f
https://doi.org/10.1016/j.etap.2012.08.007

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Herbal modulation of drug bioavailability: enhancement of rifampicin levels in plasma by herbal products and a flavonoid glycoside derived fromCuminum cyminum

Autor: Sheikh A. Tasduq, Gulam Nabi Qazi, Naresh Kumar Satti, B.S. Sachin, K. A. Suri, Sadhana Sharma, Rakesh Kamal Johri, Manoj Kumar Tikoo, Sumit Sethi, Ashok Kumar Tikoo, B. D. Gupta

Publikováno v: Phytotherapy Research. 21:157-163

The bioavailability of rifampicin (RIF) in a fixed dose combination (FDC) used for the treatment of tuberculosis remains an area of clinical concern and several pharmaceutical alternatives are being explored to overcome this problem. The present stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e848982b395e0bb1bad7894b2a4e6378
https://doi.org/10.1002/ptr.2046

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Discovery of novel pyrazolopyrimidinone analogs as potent inhibitors of phosphodiesterase type-5

Autor: Promod Kumar Sahu, Gurdarshan Singh, Subhash Chander Sharma, Mohd Ishaq Dar, Priya Mahajan, Manoj Kumar Tikoo, Sanghapal D. Sawant, Gourav Gupta, Amit Nargotra, Ram A. Vishwakarma, Sajad Hussain Syed, Surjeet Singh, G. Lakshma Reddy, M. Srinivas

Publikováno v: Bioorganicmedicinal chemistry. 23(9)

Cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type-5 (PDE5), a clinically proven target to treat erectile dysfunction and diseases associated with lower cGMP levels in humans, is present in corpus cavernosum, heart, lung, platelets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5312c19b37a04aeed74b86fa7344adc
https://pubmed.ncbi.nlm.nih.gov/25801159

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Development of a validated UPLC-qTOF-MS Method for the determination of curcuminoids and their pharmacokinetic study in mice

Autor: Rajneesh Anand, Mahendra K. Verma, Subhash Chander Sharma, Ishtiyaq Ahmad Najar, Rakesh Kamal Johri, Gurdarshan Singh, Ravi Kant Khajuria, D. K. Gupta, Manoj Kumar Tikoo

Publikováno v: DARU Journal of Pharmaceutical Sciences

Background: A specific and sensitive UPLC-qTOF-MS/MS method has been developed for the simultaneous determination of curcuminoids. These Curcuminoids comprises of curcumin, a principal curcuminoid and other two namely, demethoxycurcumin, and bisdemet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7125a5f7a28c9edde8ea7cfae861e9
https://pubmed.ncbi.nlm.nih.gov/23356399

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Development and Validation of a RP-HPLC Method for the Simultaneous Determination of Rifampicin and a Flavonoid Glycoside - A Novel Bioavailability Enhancer of Rifampicin

Autor: Manoj Kumar Tikoo, Vandhna Bhat, Meenakshi Koul, Krishan Avtar Suri, Ashok Kumar Tikoo, Rakesh Kamal Johri, Naresh Kumar Satti, B.S. Sachin, Subhash Chander Sharma

Publikováno v: Tropical Journal of Pharmaceutical Research; Vol 8, No 6 (2009)

Purpose: To develop and validate a sensitive HPLC method for the separation and simultaneous estimation of two ingredients in a composition comprising of rifampicin and a flavonoid glycoside (anenhancer of oral bioavailability of rifampicin). Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1a7349e6d736d7d6307d827b6cb50f
https://doi.org/10.4314/tjpr.v8i6.49400

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Pharmacokinetic interaction of some antitubercular drugs with caraway: implications in the enhancement of drug bioavailability

Autor: B. D. Gupta, R.K. Johri, Naresh Kumar Satti, B.S. Sachin, Shubham Sharma, P Monica, K. A. Suri, Ashok Kumar Tikoo, Manoj Kumar Tikoo

Publikováno v: Humanexperimental toxicology. 28(4)

This study deals with the pharmacokinetic interaction of selected anti-TB drugs with a natural product (CC-1a) derived from caraway ( Carum carvi, L.) seed. CC-1a, chemically standardized butanolic fraction, enhanced the plasma levels of rifampicin,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c81d6899d65fb72fb1416d538bb5f78
https://pubmed.ncbi.nlm.nih.gov/19734267

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