Development of a Self-Adjuvanting, Cross-Protective, Stable Intranasal Recombinant Vaccine for Shigellosis

Autor: Manoj K. Chakrabarti, Debaki Ranjan Howlader, Suhrid Maiti, Vinod V Patil, Dhirendra S. Katti, Hemanta Koley, Namrata Baruah, Nadim Ahamad, Ushasi Bhaumik

Publikováno v: ACS infectious diseases. 7(12)

With the acquirement of antibiotic resistance, Shigella has resulted in multiple epidemics of shigellosis, an infectious diarrheal disease, causing thousands of deaths per year. Unfortunately, there are no licensed vaccines, primarily due to low or s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5eaab66dcff0957c1809079ab5bb51
https://pubmed.ncbi.nlm.nih.gov/34734708

Outer membrane protein A (OmpA) of Shigella flexneri 2a induces TLR2-mediated activation of B cells: involvement of protein tyrosine kinase, ERK and NF-κB.

Autor: Rajsekhar Bhowmick, Debasis Pore, Manoj K Chakrabarti

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109107 (2014)

B cells are critically important in combating bacterial infections and their differentiation into plasma cells and memory cells aids bacterial clearance and long-lasting immunity conferred by essentially all vaccines. Outer membrane protein A (OmpA)

Externí odkaz: https://doaj.org/article/0b54dee66f1549888c092361479ab0a3

List of Contributors

Autor: Ashok K. Adya, Neelesh Agarwal, Udita Agrawal, Vasco Azevedo, Shiv Bahadur, Subhadip Banerjee, Debmalya Barh, Mausumi Bharadwaj, Anant Narayan Bhatt, Atanu Bhattacharjee, Sayan Biswas, Madhu Biyani, Manish Biyani, Elisabetta Canetta, Manoj K. Chakrabarti, Joydeb Chanda, Partha K. Chandra, Rakhi Chaturvedi, Ankit Chauhan, Sudhir Chowbina, D. Kar Chowdhuri, Madhumita Roy Chowdhury, Mukul Das, Amrita Datta, Devyani Dube, Sudhisha Dubey, Shanta Dutta, Bilikere Srinivasa Rao Dwarakanath, Premendra D. Dwivedi, Rajarshi Kumar Gaur, Preetam Ghosh, Jessica L. Gimpel, Abhik Gupta, Anuj Kumar Gupta, Madhu Gupta, UD Gupta, Ranjit K. Harwansh, Rajat Hazra, Kazi Mirajul Hoque, Showket Hussain, Pooja Jain, Anurag Jyoti, Shivali Kamal, Satyajyoti Kanjilal, Sudhir Kumar Kashyap, Chandra Kant Katiyar, Fahim Halim Khan, Zafar K. Khan, Suchit Khanna, Satyendra Mohan Paul Khurana, Aruna Kumar, Naveen Kumar, Sandeep Kumar, Vineet Kumar, Vipin Kumar, Noor A Lokman, Sunil Maherchandani, Avinash Marwal, Shet Masih, Pawan Kumar Maurya, Ravi Mehrotra, Ayushi Mishra, Nishi Mody, Debasis Mondal, Pulok K. Mukherjee, Soumen Mukherjee, Joseph J. Nalluri, Koichi Nishigaki, Nishu Nishu, Martin K Oehler, Bhakti Patel, Debasis Pore, Pravinkumar Purushothaman, K. Ravi Ram, M. Reza Khorramizadeh, Carmela Ricciardelli, Farshid Saadat, Malay Kumar Saha, Emmanuel O. Salawu, Rishi Shanker, Rajeev Sharma, Anchal Singh, Gulshan Singh, Mithilesh Singh, Neha Singh, Surinder Pal Singh, Priyanka Srivastava, Mark A. Suckow, Surajit Das, Richa Tripathi, Kailash C. Upadhyaya, Timsy Uppal, Alok Kumar Verma, Anju Verma, Ashish Swarup Verma, Megha Verma, Mudit Verma, Mukesh Verma, Poonam Verma, Subhash Chandra Verma, Vipin Verma, Suresh P. Vyas, Dinesh K. Yadav, Neelam Yadav, Koji Yamanaka, Eugenia Ch. Yiannakopoulou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad0e35c7db40761f8211fec2bdf74ca2
https://doi.org/10.1016/b978-0-12-811710-1.00043-4

Thermostable direct hemolysin downregulates human colon carcinoma cell proliferation with the involvement of E-cadherin, and β-catenin/Tcf-4 signaling.

Autor: Pinki Chowdhury, Debasis Pore, Nibedita Mahata, Poulomee Karmakar, Amit Pal, Manoj K Chakrabarti

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e20098 (2011)

BackgroundColon cancers are the frequent causes of cancer mortality worldwide. Recently bacterial toxins have received marked attention as promising approaches in the treatment of colon cancer. Thermostable direct hemolysin (TDH) secreted by Vibrio p

Externí odkaz: https://doaj.org/article/647700d454be44488493dc1dd9a9659a

Studies on a novel serine protease of a ΔhapAΔprtV Vibrio cholerae O1 strain and its role in hemorrhagic response in the rabbit ileal loop model.

Autor: Aurelia Syngkon, Sridhar Elluri, Hemanta Koley, Pramod K Rompikuntal, Dhira Rani Saha, Manoj K Chakrabarti, Rupak K Bhadra, Sun Nyunt Wai, Amit Pal

Publikováno v: PLoS ONE, Vol 5, Iss 9, p e13122 (2010)

Two well-characterized proteases secreted by Vibrio cholerae O1 strains are hemagglutinin protease (HAP) and V. cholerae protease (PrtV). The hapA and prtV knock out mutant, V. cholerae O1 strain CHA6.8ΔprtV, still retains residual protease activity

Externí odkaz: https://doaj.org/article/0b0f5764fc3f4f0e9e6135b6dc05f7e5