Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Manoj Govindarajulu"'
Publikováno v:
Neurotrauma Reports, Vol 4, Iss 1, Pp 586-597 (2023)
Blast-induced traumatic brain injury (bTBI) frequently results in sleep and circadian rhythm disturbances. We have investigated whether dysregulation of circadian rhythm after bTBI is mediated by dysregulation of clock genes in the hypothalamus and p
Externí odkaz:
https://doaj.org/article/458293b1de7f441a85d254d40c154b18
Autor:
Suhrud Pathak, Kelsee K. Zajac, Manjusha Annaji, Manoj Govindarajulu, Rishi M. Nadar, Dylan Bowen, R. Jayachandra Babu, Muralikrishnan Dhanasekaran
Publikováno v:
Cancer Reports, Vol 6, Iss S1, Pp n/a-n/a (2023)
Abstract Background Choosing the most effective chemotherapeutic agent with safest side effect profile is a common challenge in cancer treatment. Although there are standardized chemotherapy protocols in place, protocol changes made after extensive c
Externí odkaz:
https://doaj.org/article/d46f56db5f764bd2b26dbda11d6f28da
Autor:
Suhrud Pathak, Rishi Nadar, Shannon Kim, Keyi Liu, Manoj Govindarajulu, Preston Cook, Courtney S. Watts Alexander, Muralikrishnan Dhanasekaran, Timothy Moore
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 853 (2024)
As the kynurenine pathway’s links to inflammation, the immune system, and neurological disorders became more apparent, it attracted more and more attention. It is the main pathway through which the liver breaks down Tryptophan and the initial step
Externí odkaz:
https://doaj.org/article/f9c5e581c9054314b519621da2e993e3
Autor:
Manoj Govindarajulu, Sindhu Ramesh, Tharanth Shankar, Murali Krishna Kora, Timothy Moore, Muralikrishnan Dhanasekaran
Publikováno v:
NeuroSci, Vol 3, Iss 4, Pp 533-545 (2022)
Neurodegenerative diseases are characterized by progressive loss of neurons in specific regions of the brain. Neuronal death is often associated with the accumulation of misfolded proteins due to genetic mutations or abnormal protein homeostasis. An
Externí odkaz:
https://doaj.org/article/0e215285fa8c451d9551a9a09333f97b
Autor:
Satyanarayana R Pondugula, Julia M Salamat, Kodye L Abbott, Patrick C Flannery, Mohammed Majrashi, Mohammed Almaghrabi, Manoj Govindarajulu, Sindhu Ramesh, Maninder Sandey, Suneel K Onteru, Chen-Che J Huang, Yoshimi Iwaki, Kristina Gill, Natasha Narayanan, Edwin McElroy, Darshini Desai, Rishi Nadar, Timothy Moore, Muralikrishnan Dhanasekaran
Publikováno v:
Liver Research, Vol 5, Iss 4, Pp 239-242 (2021)
Background and aims: Chronic exposure to chemotherapeutics can lead to severe adverse events including hepatotoxicity. A combination chemotherapy regimen of doxorubicin (DOX) and cyclophosphamide (CPS) is employed in treatment of several cancers such
Externí odkaz:
https://doaj.org/article/b543ccd923174a20bc3ae2a759de9786
Autor:
Mohammed Majrashi, Mansour Altukri, Sindhu Ramesh, Manoj Govindarajulu, Jack Schwartz, Mohammed Almaghrabi, Forrest Smith, Tony Thomas, Vishnu Suppiramaniam, Timothy Moore, Miranda Reed, Muralikrishnan Dhanasekaran
Publikováno v:
Journal of Integrative Neuroscience, Vol 20, Iss 2, Pp 321-329 (2021)
Ketone bodies have been the topic of research for their possible therapeutic neurotropic effects in various neurological diseases such as Parkinson’s disease, dementia, and seizures. However, continuing research on ketone bodies as a prophylactic a
Externí odkaz:
https://doaj.org/article/85d2a112058f40de8aa284882bc4bb95
Autor:
Manoj Govindarajulu, Sindhu Ramesh, McNeil Beasley, Graham Lynn, Caleigh Wallace, Sammie Labeau, Suhrud Pathak, Rishi Nadar, Timothy Moore, Muralikrishnan Dhanasekaran
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8151 (2023)
There is mounting evidence that the development of Alzheimer’s disease (AD) interacts extensively with immunological processes in the brain and extends beyond the neuronal compartment. Accumulation of misfolded proteins can activate an innate immun
Externí odkaz:
https://doaj.org/article/f2d6557dc3a949a59cd4def76d152e01
Autor:
Ian Steinke, Manoj Govindarajulu, Priyanka Das Pinky, Jenna Bloemer, Sieun Yoo, Tracey Ward, Taylor Schaedig, Taylor Young, Fajar Setyo Wibowo, Vishnu Suppiramaniam, Rajesh H. Amin
Publikováno v:
Cells, Vol 12, Iss 8, p 1116 (2023)
Background: The continuously increasing association of Alzheimer’s disease (AD) with increased mortality rates indicates an unmet medical need and the critical need for establishing novel molecular targets for therapeutic potential. Agonists for pe
Externí odkaz:
https://doaj.org/article/2fbd99e168df406dbcc48482f9890c02
Autor:
Rachel S Parise, Sindhu Ramesh, Manoj Govindarajulu, Amir Ajoolabady, Timothy Moore, Muralikrishnan Dhanasekaran
Publikováno v:
Cardiology Plus, Vol 6, Iss 4, Pp 231-245 (2021)
Viral infections persist globally, among all ages, gender, and ethnicity. Of particular importance is COVID-19, associated with asymptomatic to severe symptoms, including complications/mortality. Cardiovascular disease (CVD) involves heart and blood
Externí odkaz:
https://doaj.org/article/089c5b0abad44ae18280e91992dc68f8
Publikováno v:
Brain Sciences, Vol 12, Iss 10, p 1340 (2022)
Blast-induced traumatic brain injury (bTBI) frequently results in sleep-wake disturbances. However, limited studies have investigated the molecular signaling mechanisms underlying these sleep disturbances, and potentially efficacious therapies are la
Externí odkaz:
https://doaj.org/article/086e5a47057e44569fc9f05258ee4108